Effects of Vanadium Pentoxide on the Histological and Sperm Parameters of Male Guinea Pigs

Uche, FI; Obianime, AW; Gogo-Abite, M

doi:10.4314/jasem.v12i3.55512

Cited by 11 publications

(11 citation statements)

References 8 publications

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“…The histopathological damage of the liver also confirms the hepatotoxic levels of cadmium chloride with an increase in urea, creatinine, acid and prostatic acid levels. This is consistent with the earlier works of Goering et al 1994;Habeebu et al 1998;Stoh et al 2000;Massanyi et al 2007;Uche et al 2008). Furthermore, these generalized toxic indices (Friberg 1986) also positively correlated with the damage caused to the testicular tissue.…”

Section: Fig 2 the Time-dependent Effects Of 2mg Of Cadmium On A) Biosupporting

confidence: 92%

Antioxidants, cadmium-induced toxicity, serum biochemical and the histological abnormalities of the kidney and testes of the male wistar rats

Obianime

Byron²

2010

Nig. J. Phys Sci

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Summary:The effects of different doses of cadmium (CD) on some biochemical, hormonal and histopathological parameters of the liver, kidney and testes of the Wister rate were investigated. Cadmium (CD) in the dose range 0-40mg/kg while causing a time-and dose-dependent decrease of the basal serum levels of alkaline phosphatese (ALP) also caused a dose-dependent increase in the serum concentration of the acid and prostatic acid phosphatases. The value of the ALP changed from 148.7±1.0 IU/L in the control to 53.7±0.098 at 40mg/kg of cadmium. While the ACP and ACPT changed from 32.6±0.72 and 7 ±Units in the control to 54 and 17 units respectively at 40mg/kg of CD. Furthermore Cadmium also caused positively correlated dose-and time-dependent destruction of the histology of the liver, kidney and testes. These were characterized by vascular congestion, vacuolation, destruction of the seminal epithelial layers, focal necrosis of nucleus, Oedema of the seminal epithelia layers, focal necrosis of nucleus, oedema of the seminiferous tubules and reduction of spermatogenesis. CD also caused granular and eosinophilic cytoplasm, enlargement of sinusoids with kupffer cells, haemorrhage and apoptosis of cells. Finally pre-treatment with vitamin C (0.0015/kg), vitamin E (1.51/gm) and selenium (0.25mg) which on their own had little or no effects on the serum basal phosphatases, hormonal and histological stability caused a reversal of the cadmium-induced biochemical, hormonal and histological toxicities of the liver, kidney and testes. These results may be explained by the oxidational/antioxidational properties of these xeonobiotics and their mechanisms of actions.

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Section: Fig 2 the Time-dependent Effects Of 2mg Of Cadmium On A) Biosupporting

confidence: 92%

Antioxidants, cadmium-induced toxicity, serum biochemical and the histological abnormalities of the kidney and testes of the male wistar rats

Obianime

Byron²

2010

Nig. J. Phys Sci

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“…Also vanadate caused a dose-and timedependent inhibition of the serum hormonal levels and these results were consistent with previous reports on the effects of vanadate on the animal studies (Uche & Obianime 2008). These results were not qualitative neither were they correlated to histopathological stimulation of various phosphatases, which are indices of general toxicity and an increase which is an index of toxicity of the prostate and testicular tissues (Eyo 2003, Hirano et al 1990, Stohs et al 2001, Shimizu & Morita.…”

Section: Fig 3 Photomicrographs Of the Effects Of Different Doses Of supporting

confidence: 92%

“…Furthermore, it also caused hormonal depressions/inhibitions which were positively correlated to the histological damages to uterus, ovaries and oviduct, showing that the histological destruction resulted in the pathophysiological decreases in hormonal production and function which may lead to infertility (Gupta et al 2004, Uche & Obianime 2008and Lafuente 2000. This aspect of positive correlation between structure and function is novel as no other studies had ever undertaken such.…”

Section: Fig 3 Photomicrographs Of the Effects Of Different Doses Of mentioning

confidence: 94%

The effects of ammonium metavanadate on biochemical hormonal, haematological and histopathological parameters of the female wistar rats

Obianime¹,

Gogo-Abite²,

Byron³

2010

Nig. J. Phys Sci

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Summary:The effects of different doses of Ammonium metavanadate on the biochemical, haematological, hormonal and histopathological parameters of stilbesterol treated female Wistar rats were investigated. Ammonium metavanadate in the dose-range 0-6mg/kg caused a bi-phasic and time-dependent response on the acid (total and prostate) phosphatase.. Furthermore ammonium metavanadate caused a dose-dependent inhibition of the serum alkaline phosphatases. The maximal inhibitory response at 5mg/kg of ammonium metavanadate was 40.0 ± 1.69 compared to 65.0 ± 0.94 control values. Ammonium metavanadate also caused a positively correlated biphasic response in the serum female hormonal concentrations with an initial increase, followed by a time-dependent decrease in the serum values of luteinizing (LH), follicle stimulating hormone (FSH), prolactin . Furthermore ammonium metavanadate also caused time-and dose-dependent effects on the haematological parameters. The effects were biphasic-increase within 72 hours and a reduction in the values of haemoglobin and packed cell volume within 7-28 days. The white blood count and lymphocyte counts were also reduced significantly at P ≤ 0.05. However the neutrophil counts were increased dose-and time-dependently. Finally, ammonium metavanadate caused a dose-dependent destruction of the liver and female reproductive organs namely the uterus, ovary and fallopian tubes. These were characterized by necrosis, oedema, eosinophilic deposits and vacuolation. These results may be explained by the oxidative effects caused by the free oxygen (O 2 ) radical generated by the metavanadate ions.

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“…It is genotoxic, 79 and causes destruction of the testicular and liver architecture in male guinea pigs, and has been reported to be a developmental toxicant in mice. 80 To our knowledge, there is no specific data on the 2D (exfoliated) forms of V 2 O 5 .…”

Section: Literature Review On Biological Response and Riskmentioning

confidence: 98%

Biological and environmental interactions of emerging two-dimensional nanomaterials

Wang¹,

Zhu²,

Qiu³

et al. 2016

Chem. Soc. Rev.

239

210

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Two-dimensional materials have become a major focus in materials chemistry research worldwide with substantial efforts centered on synthesis, property characterization, and technological application. These high-aspect ratio sheet-like solids come in a wide array of chemical compositions, crystal phases, and physical forms, and are anticipated to enable a host of future technologies in areas that include electronics, sensors, coatings, barriers, energy storage and conversion, and biomedicine. A parallel effort has begun to understand the biological and environmental interactions of synthetic nanosheets, both to enable the biomedical developments and to ensure human health and safety for all application fields. This review covers the most recent literature on the biological responses to 2D materials and also draws from older literature on natural lamellar minerals to provide additional insight into the essential chemical behaviors. The article proposes a framework for more systematic investigation of biological behavior in the future, rooted in fundamental materials chemistry and physics. That framework considers three fundamental interaction modes: (i) chemical interactions and phase transformations, (ii) electronic and surface redox interactions, and (iii) physical and mechanical interactions that are unique to near-atomically-thin, high-aspect-ratio solids. Two-dimensional materials are shown to exhibit a wide range of behaviors, which reflect the diversity in their chemical compositions, and many are expected to undergo reactive dissolution processes that will be key to understanding their behaviors and interpreting biological response data. The review concludes with a series of recommendations for high-priority research subtopics at the “bio-nanosheet” interface that we hope will enable safe and successful development of technologies related to two-dimensional nanomaterials.

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Effects of Vanadium Pentoxide on the Histological and Sperm Parameters of Male Guinea Pigs

Cited by 11 publications

References 8 publications

Antioxidants, cadmium-induced toxicity, serum biochemical and the histological abnormalities of the kidney and testes of the male wistar rats

Antioxidants, cadmium-induced toxicity, serum biochemical and the histological abnormalities of the kidney and testes of the male wistar rats

The effects of ammonium metavanadate on biochemical hormonal, haematological and histopathological parameters of the female wistar rats

Biological and environmental interactions of emerging two-dimensional nanomaterials

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