Effects of Vasoactive Agents on Blood Loss and Transfusion Requirements During Pre-Reperfusion Stages of the Orthotopic Liver Transplantation

Vasopressin‐induced changes in splanchnic blood flow and hepatic and portal venous pressures in liver resection

“…4 Several methods to reduce these pressures have previously been described, such as fluid restriction, use of diuretics, vasodilators (nitroglycerine infusion), 5,6 epidural anaesthesia, 7 phlebotomy 8 and changes in patient positioning. 12 Terlipressin, a synthetic analogue of vasopressin, has also been shown to reduce blood loss 13 and the incidence of acute kidney injury after liver transplantation. 12 Terlipressin, a synthetic analogue of vasopressin, has also been shown to reduce blood loss 13 and the incidence of acute kidney injury after liver transplantation.…”

“…9,10 Vasopressin acts on V1 receptors in the hepato-splanchnic vascular bed and produces a potent vasoconstriction, which leads to reduced portal pressure and flow in patients with portal hypertension 11 and has been shown to reduce bleeding in liver transplantation. 12 Terlipressin, a synthetic analogue of vasopressin, has also been shown to reduce blood loss 13 and the incidence of acute kidney injury after liver transplantation. 14 In this study, we examined the effects of low to moderate doses of vasopressin on pressure and flow changes in the portal and hepatic veins, that is, splanchnic and hepato-splanchnic blood flows, as well as changes in systemic haemodynamics, in patients undergoing liver resection.…”

A Review on Stem cell Research & Their Role in Various Diseases

“…Liver stem cells [61,62] harvested from the bone marrow can further augment and accelerate the liver's natural capacity to regenerate itself. Although the liver [63,64] can regenerate in the body, liver failure caused by diseases like cirrhosis and cancers eventually destroy the liver's regenerative ability [65,66].…”

Stem Cell Therapy for Liver Diseases

“…The most commonly used technique is orthotopic transplantation, in which the native liver is removed and replaced by the donor organ in the same anatomic location as the original liver [37]. The transplant operation can be conceptualized as consisting of the hepatectomy (liver removal) phase, the anhepatic (no liver) phase, and the post implantation phase [ [51,52].…”