Effects of vasoactive intestinal polypeptide (VIP) on renal function and plasma renin activity in the conscious rabbit.

Abstract

SUMMARY1. Conscious rabbits received either vasoactive intestinal polypeptide (VIP) at a dose of 1, 10 or 25 pmol kg-' min-or vehicle alone (control) through an ear vein for 2 h. Experimental design followed a randomized Latin square arrangement.2. VIP led to a decrease in effective renal plasma flow and glomerular filtration rate (P < 0-01) during infusion of the middle and high doses. Mean arterial blood pressure rose slightly (P < 0 05) and filtration fraction increased (P < 0 01) during infusion ofthe middle dose. The high dose produced a rise in heart rate, a fall in plasma sodium, potassium and phosphate concentrations and a rise in plasma solids (P < 0-01).3. In spite of the renal haemodynamic effects and changes in plasma composition during infusion of the high dose, fractional excretion of sodium, potassium and chloride doubled (P < 005), suggesting a direct action of VIP on renal tubular function.4. Plasma renin activity increased between 2-and 3-fold (P < 0-01). The mechanism of the renin response is uncertain.5. These results, together with the reported presence of VIP-like material in the renal cortex, may indicate a role for VIP in the regulation of renal function, including renin release.

Vasoactive intestinal polypeptide regulation of rabbit renal adenylate cyclase activity in vitro.

“…It is primarily recognized for its actions on the gastrointestinal tract from where it was first isolated (see Mutt, 1982) and where it is probably involved in the control of intestinal secretion of salt and water (Krejs, 1982). Some data exist on the regulation of renal function by VIP, as infusions of VIP may affect renin release, renal haemodynamics and renal tubular function (Calam et al 1983;Dimaline et al 1983;Porter et al 1985;Rosa et al 1985). A physiological regulatory role for VIP upon renal function would require a response to either circulating plasma VIP, or to VIP released from nerve terminals present in the kidney.…”

“…Infusions of VIP are known to influence both renal haemodynamics and the release of renin (Porter & Ganong, 1982;PHY 387 N. M. GRIFFITHS AND N. L. SIMMONS Porter, Said & Ganong, 1983;Dimaline et al 1983;Porter, Thrasher, Said & Ganong, 1985). In addition there seems to be evidence for a role for VIP regulation of tubular transport unconnected with haemodynamic effects Rosa, Silva, Stoff & Epstein, 1985).…”

Effects of vasoactive intestinal polypeptide on renal function in man.

“…This peptide affects both the calibre ofblood vessels and movements ofwater and electrolytes in other organs (Fahrenkrug, 1980), and has been shown to alter renal function in the isolated perfused rat kidney (Rosa, Stoff, Silva & Epstein, 1977), the anaesthetized dog (Porter, Reid, Said & Ganong, 1980) and the conscious rabbit (Dimaline, Peart & Unwin, 1983). The most striking effect is the stimulation of renin release, but renal plasma flow, glomerular filtration rate and tubular function may also be altered.…”

Regional haemodynamic responses to pituitary adenylate cyclase‐activating polypeptide and vasoactive intestinal polypeptide in conscious rats

“…In dogs (Porter et al, 1982), and rabbits (Dimaline et al, 1983), VIP stimulates renin release, possibly through direct and indirect mechanisms. However, there are no data available relating to the involvement of the renin-angiotensin system in the regional haemodynamic responses to VIP and so, our fourth objective was to determine the effects of the AT,-receptor antagonist, losartan potassium (DuP 753; Wong et al, 1990;Batin et al, 1991) on regional haemodynamic responses to PACAP27 or VIP in conscious rats.…”