Effects of Vitamin D Deficiency in Polycystic Ovarian Syndrome

Al-Ghanny, Rand Jalal Abd; Al-Moosawi, Mohanned Mohammed Bakir; Ahmed, Baydaa

doi:10.24996/ijs.2022.63.1.4

Cited by 4 publications

(3 citation statements)

References 27 publications

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“…The hepatic lipase's metabolism of these particles quickens when the Tg content of HDL rises [20].Additionally, the nature of LDL changes: there are more tiny, dense, oxidation-prone LDL particles, which leads to higher amounts of oxidized LDL and faster atherogenesis [21] [22].Endothelial dysfunction and the promotion of atherosclerosis are caused by a combination of low HDL, high small and dense LDL, hyperinsulinemia , hyperglycemia, and hypertriglyceridemia [23].Previous research has shown that 13% of AFM is attached to lipoproteins in the bloodstream, mostly to tiny, dense HDL particles but also to HDL that contains A1 apolipoprotein. Plasma lipoproteins contain 97% of the lipid-soluble and γ-tocopherol [24] [25]. But there are other proteins besides AFM that can also bind these γ-tocopherols selectively.…”

Section: Type 2 Diabetes Mellitus and Obesitymentioning

confidence: 99%

A Review of Afamin A Metabolic Novel Marker of Many Diseases

Layla

2023

wjps

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Human plasma vitamin E-binding glycoprotein afamin is mostly produced in the liver and released into the circulation. The review in this study related to a glycoprotein afamin marker that is important in many disease(Type 2 diabetes mellitus,cancer,obesity , Gestational diabetes mellitus,oxidative stress,and metabolic syndrome. Although ovarian follicles and human cerebrospinal fluid also contain sizable amounts of AFM, the liver is the main organ that generates it. Though there are minor AFM manifestations have been also reported in the human heart, testis, brain, kidney, and ovary. Afamin is promising metabolic novel marker for gestational diabetes,type 2 diabetes mellitus cancer,metabolic syndrome,and related disease.

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Section: Type 2 Diabetes Mellitus and Obesitymentioning

confidence: 99%

A Review of Afamin A Metabolic Novel Marker of Many Diseases

Layla

2023

wjps

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“…Obesity is associated with greater myostatin expression, according to a number of studies 9,10 . Wild-type mice fed a high-fat diet for a month and genetically obese, leptin-deficient ob/ob mice both had increased skeletal muscle and fatty tissue myostatin mRNA levels 11,12 .…”

Section: Introductionmentioning

confidence: 99%

Studying Myostatin as a Diagnostic Indicator in Sera of Iraqi Women with Metabolic Syndrome

Assaf,

Farhan

2024

Baghdad Sci.J

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Obesity in the abdominal area, insulin resistance, hyperglycemia, dyslipidemia, and hypertension are all included as part of metabolic syndrome. Myocytes manufacture and release the myokine known as myostatin, which acts on muscle cells inhibiting cellular growth. This study aimed to compare Myostatin along with other biochemical parameters (Fasting blood sugar (FBS), cholesterol, high-density lipoprotein (HDL), triglycerides (T.G), low-density lipoprotein (LDL), and very Low-density lipoprotein (VLDL)) in sera of Iraqi with metabolic syndrome patients and healthy subjects. Eighty women were separated into two groups: group I, 40 metabolic disorders patients, and group II, 40 healthy people, which served as the control group. Myostatin levels significantly increased compared to the control group in the group with metabolic syndrome, according to the data p > 0.001. A definite cut-off value was visible on the Myostatin ROC curve (5), in the metabolic syndrome. The outcomes suggest myostatin as possible diagnostic tool for metabolic syndrome.

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“…Polycystic ovarian syndrome (PCOS) is a major cause of infertility in women (1). PCOS can have major repercussions, such as an increased chance of endometriosis and neoplasia (2).…”

Section: Introductionmentioning

confidence: 99%

Association between serum fructose level and insulin resistance in women with polycystic ovary syndrome: The effect of obesity

2022

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Background: Polycystic ovary syndrome (PCOS) women's most prevalent endocrinology condition is a mixture of environmentally and genetically adduced causing PCOS. The relationship between monosaccharide and PCOS is largely unknown. Objective: This research was designed to investigate the relationship between blood levels of fructose, insulin resistance, and androgen hormone in women with PCOS, and the effect of obesity on the obtained result, as well as to study the efficacy of serum fructose as a biomarker in the diagnosis of PCOS. Cases and methods: This case-control research study was conducted at the Gynecology Clinic and Infertility Center, in Baghdad Teaching Hospital / Medical City between November 2021 to March 2022. It involved 120 women between the ages of 18-40 year. Fifty-nine women (cases) were newly diagnosed with PCOS by a gynecologist and 61 age and BMI matched healthy women (controls). PCOS women were subdivided according to their body mass index into four groups: lean, normal weight, overweight and obese. Investigations included serum measurements of fructose, luteinizing hormone (LH), follicular stimulating hormone (FSH), free testosterone, insulin, glucose, and calculated homeostasis model assessment- insulin resistance (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI). Results: The mean ±SD values of serum fructose, glucose, insulin and HOMA-IR were significantly augmented in PCOS women as compared to controls (p< 0.001), while mean value of QUICKI was significantly decreased (p<0.0001). There was a significant positive correlation between BMI values and fructose levels in PCOS women. The result showed that serum fructose and free testosterone levels had the highest sensitivity and specificity in the differentiation between the PCOS group and the controls, with the area under curve values for free testosterone higher than area under curve values for fructose. Conclusions: The fructose level can be used as an alternative biomarker for women with PCOS independent of insulin resistance. The majority of PCOS women are obese and overweight, and a minority are lean who are severely complicated by insulin resistance.

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Effects of Vitamin D Deficiency in Polycystic Ovarian Syndrome

Cited by 4 publications

References 27 publications

A Review of Afamin A Metabolic Novel Marker of Many Diseases

A Review of Afamin A Metabolic Novel Marker of Many Diseases

Studying Myostatin as a Diagnostic Indicator in Sera of Iraqi Women with Metabolic Syndrome

Association between serum fructose level and insulin resistance in women with polycystic ovary syndrome: The effect of obesity

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