Effects of vitamin D on the peripheral adaptive immune system: A review

Peelen, Evelyn; Knippenberg, Stephanie; Muris, Anne-Hilde; Thewissen, Mariëlle; Smolders, Joost; Tervaert, Jan Willem Cohen; Hupperts, Raymond; Damoiseaux, Jan

doi:10.1016/j.autrev.2011.05.002

Cited by 213 publications

(190 citation statements)

References 115 publications

Supporting

Mentioning

185

Contrasting

Unclassified

Order By: Relevance

“…3,9 Evidence from in vitro studies indicates that 1,25(OH)2D exerts a suppressive effect on the synthesis of proinfl ammatory cytokines IFN-γ, IL2, IL17 and a stimulating effect on the anti-infl ammatory Th2 mediated secretion of IL4, IL5, IL13 and regulatory CD4+ CD25+ Foxp3+ Ly subpopulation. 3,[10][11][12] Treating experimental allergic encephalomyelitis (EAE) with vitamin D metabolites prevents further development of the model if these metabolites are applied prior to the induction with myelin protein and inhibit the progressive development if applied after the fi rst clinical signs. Therapy with 1,25(OH)2D inhibits the synthesis of TNF-α, IFN-γ, IL17, increases the secretion of IL4, stimulates the production of TGFβ1 and IL10 from Т-regulatory subpopulations, suppressing immune reaction.…”

Section: Immunomodulatory Activity Of Vitamin D -Results From Epidemimentioning

confidence: 99%

Vitamin D Immunomodulatory Potential in Multiple Sclerosis

Slavov¹,

Trenova²,

Manova³

et al. 2013

Folia Medica

View full text Add to dashboard Cite

Multiple sclerosis (MS) is an autoimmune disease of unknown etiology whose treatment is of limited effi ciency and therefore has a high social burden. As it has been suggested that myelin destruction model, the clinical manifestation and the potential of therapeutic response in MS are correlated, it is quite justifi able that we study various factors (genetic, hormonal, environmental) that take part in the autoimmune process in order to improve the control over the disrupted immune regulation.

show abstract

Section: Immunomodulatory Activity Of Vitamin D -Results From Epidemimentioning

confidence: 99%

Vitamin D Immunomodulatory Potential in Multiple Sclerosis

Slavov¹,

Trenova²,

Manova³

et al. 2013

Folia Medica

View full text Add to dashboard Cite

show abstract

“…Moreover, vitamin D can modulate Ig production and exert direct effects on Bcell homeostasis. Indeed, it has been observed that differentiation into plasma cells and post-switch memory B cells was inhibited in the presence of 1,25(OH) 2 D [7].…”

Section: (Oh)d Values Than Healthy Controls (P =mentioning

confidence: 99%

Vitamin D and thyroid autoimmune diseases: the known and the obscure

Bizzaro

Shoenfeld

2014

Immunol Res

View full text Add to dashboard Cite

Vitamin D is a secosteroid hormone, obtained from the diet or synthesized in human skin from 7-dehydrocholesterol after UV irradiation exposure. Its importance in calcium homeostasis is well recognized, as well its role in decreasing the risk of rickets, fractures, osteopenia, osteomalacia, and osteoporosis. What is a new developing issue is the involvement of vitamin D deficiency (commonly defined as less than 30 ng/ml) in the boost of many other disorders and especially in autoimmune diseases [1]. In light of these new acquisitions, vitamin D deficiency may represent a global health problem that has been underestimated for many years.Among all the autoimmune diseases which show an association with vitamin D deficiency and disease progression, we will focus on autoimmune thyroid diseases (AITD). Indeed, vitamin D deficiency modulates both Hashimoto thyroiditis (HT) and Graves' disease (GD). In several studies, the association between vitamin D and AITD was assessed analyzing various serological parameters, such as serum 25(OH)D levels, serum calcium, phosphate, parathyroid hormone (PTH), and antithyroid antibody levels. HT patients had significantly lower 25(OH)D values than healthy controls (p = 0.001), and low levels of serum 25(OH)D were also correlated with disease duration, thyroid volume, and antibody levels [2]. The association between vitamin D deficiency and antithyroid antibodies was reported for the first time by Kivity et al. [3], who studied a cohort of 92 patients with thyroid disorders, collected in a Hungarian endocrinology clinic. Antithyroid peroxidase (TPOAb) and antithyroglobulin (TgAb) antibodies were significantly more common in patients with vitamin D deficiency than in those with normal vitamin D levels. Hypovitaminosis D and thyroid autoimmunity were also described in a Chinese female population, where decreased TPOAb levels were associated with higher vitamin D levels. Interestingly, the correlation was found only in premenopausal women, but not in postmenopausal women or in men [4]. This result suggests a likely involvement of estrogens in modulating AITD. Moreover, the relationship between serum vitamin D status and thyroid-stimulating hormone (TSH) levels was investigated. Vitamin D levels were found associated with low circulating TSH levels in middle-aged and elderly males, independently of T3 and T4 levels. Interestingly, serum TSH levels in women were higher than those of same-aged men, indicating that TSH secretion may be regulated by sex hormones [5].Vitamin D status was also evaluated in female GD patients, showing significant lower levels compared with controls and demonstrating an association between serum 25(OH)D levels and serum calcium and intact parathyroid hormone levels. Recently, Yasuda and coworkers found an

show abstract

“…2) Выявлена существенная позитивная связь между затратами на ИиР университета и деятельностью по созданию спин-оф компаний [5]. Обеспеченность инновационного проекта финансовыми ресурсами на всех стадиях жизненного цикла способствует снижению риска отторжения инновации рынком и увеличивает ее эффективность [6].…”

unclassified

Трансформация ВУЗОВ В Организации Нового Типа – Предпринимательские Организации

Ускеленова¹

2017

Наука России: Цели И Задачи

View full text Add to dashboard Cite

Effects of vitamin D on the peripheral adaptive immune system: A review

Cited by 213 publications

References 115 publications

Vitamin D Immunomodulatory Potential in Multiple Sclerosis

Vitamin D Immunomodulatory Potential in Multiple Sclerosis

Vitamin D and thyroid autoimmune diseases: the known and the obscure

Трансформация ВУЗОВ В Организации Нового Типа – Предпринимательские Организации

Contact Info

Product

Resources

About