Effects of waterborne antidepressants on non-target animals living in the aquatic environment: A review

Sehonová, Pavla; Svobodová, Zdeňka; Doleželová, Petra; Vošmerová, Petra; Faggio, Caterina

doi:10.1016/j.scitotenv.2018.03.076

Cited by 240 publications

(90 citation statements)

References 80 publications

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“…Marine bivalve molluscs have complex systems to defence against infection which include humoral factors and cellular mechanism (Faggio, Pagano, Alampi, Vazzana, & Felice, ; Faggio, Tsarpali, & Dailianis, ; Sehonova, Svobodova, Dolezelova, Vosmerova, & Faggio, ). Among the humoral factors involved in the elimination of pathogens, molecules such as antimicrobial peptides, major plasma proteins, lysosomal enzymes, lectins and protease inhibitors can be considered (Matozzo, Pagano, Spinelli, Caicci, & Faggio, ; Soudant et al, ; Tiscar & Mosca, ).…”

Section: Discussionmentioning

confidence: 99%

“…Although the presence of Perkinsus is a serious threat for clam cultures, no massive mortalities related to the presence of Perkinsus mediterraneus in M. varia had been observed in Balearic Islands (Ramilo et al, 2015). (Faggio, Pagano, Alampi, Vazzana, & Felice, 2016;Faggio, Tsarpali, & Dailianis, 2018;Sehonova, Svobodova, Dolezelova, Vosmerova, & Faggio, 2018). Among the humoral factors involved in the elimination of pathogens, molecules such as antimicrobial peptides, major plasma proteins, lysosomal enzymes, lectins and protease inhibitors can be considered (Matozzo, Pagano, Spinelli, Caicci, & Faggio, 2016;Soudant et al, 2013;Tiscar & Mosca, 2004).…”

Section: Discussionmentioning

confidence: 99%

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Perkinsus mediterraneus infection induces oxidative stress in the mollusc Mimachlamys varia

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Capó

Tejada

et al. 2019

Journal of Fish Diseases

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Perkinsus mediterraneus is a protozoan parasite that can cause marine mollusc diseases known as perkinsosis being a serious threat for clam cultures worldwide. The aim of the present study was first to determine the Perkinsus species infecting the variegated scallop Mimachlamys varia and then to evaluate the existence of oxidative stress in gills of M. varia according to different degrees of infection. DNA sequencing confirmed that P. mediterraneus was the species infecting M. varia. ROS production was progressively increasing with the degree of infection although the differences were only significant in the high‐infected group. Low degree of infection significantly increased superoxide dismutase (SOD) and glutathione S‐transferase (GST) activities and nitrite levels with respect to the control group. In the high‐infected group, a significant increase was evidenced in all analysed enzymes, catalase, SOD, glutathione reductase and GST. Non‐significant differences in MDA levels were observed between the control and low‐infected groups; however, a significant increase in MDA levels was observed in the high‐infected group. In conclusion, the infection by Perkinsus mediterraneus in M. varia induces oxidative stress and an antioxidant response directly related to the infection degree that can contribute to the pathogenicity of the infection.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Perkinsus mediterraneus infection induces oxidative stress in the mollusc Mimachlamys varia

Box

Capó

Tejada

et al. 2019

Journal of Fish Diseases

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“…The aquatic environment is the ultimate recipient of an increasing amount of contaminants as a result of the discharge of industrial, agricultural, and urban wastes (Bartoskova et al, ; Capillo et al, ; Faggio, Pagano, Alampi, Vazzana, & Felice, ; Sehonova, Svobodova, Dolezelova, Vosmerova, & Faggio, ). A large number of pollutants in this complex mixture are responsible for multiple effects in organisms, including human beings, and ecosystem levels, affecting organ function, reproductive status, species survival, population size, and ultimately biodiversity (Aliko, Qirjo, Sula, Morina, & Faggio, ; Bickham, Sandhu, Hebert, Chikhi, & Athwal, ; Fazio et al, ; Fiorino et al, ; Pagano et al, ).…”

Section: Introductionmentioning

confidence: 99%

Digital light microscopy as a tool in toxicological evaluation of fish erythrocyte morphological abnormalities

Sula

Aliko

Pagano

et al. 2019

Microscopy Res & Technique

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Fish erythrocytes are very sensitive to environmental pollution because they exhibit pathological alterations before appearance of other external symptoms, may be used as reliable toxicity bioindicators. Microscopic analysis can be a useful tool in early detection of alterations in erythrocyte morphology due to different environmental stressors, and in predicting organism's possible response ways. This study aims to evaluate the toxicity of a polluted freshwater lake on the erythrocytes of crucian carp fish, Carassius carassius, using digital light microscopy (DLM). Scanning DLM micrographs revealed the presence of nuclear and cytoplasmic abnormalities like micronucleus, nuclear buds, lobed nucleus, deformed nucleus, vacuolated cytoplasm, and echinocyte in the erythrocytes of crucian carp fish from a polluted lake. The obtained results substantiate that computation of erythrocyte morphological damages as biomarkers of exposure, through digital light microscopy software, can be effectively used as a toxicological tool.

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“…Also, and as mentioned at the beginning of the Discussion, the determination of the antioxidant capacity is important to facilitate the understanding of the resilience of organisms to the toxicity caused by the generation of ROS (Amado et al, ). However, the antioxidant capacity and the intensity of oxidative damage behave differently in different organs (Aliko, Qirjo, Sula, Morina, & Faggio, ; Amado et al, ; Gobi, Vaseeharan, Rekha, Vijayakumar, & Faggio, ; Monserrat et al, ; Sehonova, Svobodova, Dolezelova, Vosmerova, & Faggio, ; Stara et al, ). In the gills, the decrease in antioxidant capacity after exposure to ammonia was similar in both diets.…”

Section: Discussionmentioning

confidence: 99%

The role of açaí ( Euterpe oleracea Mart. 1824) as a chemoprotective agent in the evaluation of antioxidant defence, oxidative damage and histology of juvenile shrimp Litopenaeus vannamei (BOONE, 1931) exposed to ammonia

et al. 2020

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This study investigated the effects of the use of the inclusion of açaí on the diet of shrimp Litopenaeus vannamei on antioxidant and histopathological responses after exposure to ammonia. The shrimps were fed two experimental diets: control and with 10% of açaí inclusion (W/W), for 35 days. Afterwards, the organisms were exposed at four concentrations of ammonia (0.01‐control; 0.26; 0.48 and 0.91 mg NH3‐N L−1) for 96 hr. The total antioxidant capacity (ACAP) of the gills decreased significantly in both diets when exposed to ammonia, whereas in the muscle, the açaí promoted an increase in ACAP. Concomitantly, lipid peroxidation levels increased in the gills and decreased in muscle. After exposure to ammonia, glutathione‐S‐transferase activity increased in hepatopancreas in shrimps fed with açaí facilitating the detoxification of lipid peroxidation by‐products, and the concentration of protein sulfhydryl groups decreased in the gills and muscle of the shrimp of the control diet, evidencing protein damage, an unobserved response in shrimps that received the açaí diet. Histopathological changes decreased in açaí‐fed shrimps about the control diet after exposure to ammonia. It is concluded that açaí mitigated ammonia‐induced histopathological changes, improved the antioxidant defence system (gills and muscle) and attenuated the lipid damage in the muscle.

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Effects of waterborne antidepressants on non-target animals living in the aquatic environment: A review

Cited by 240 publications

References 80 publications

Perkinsus mediterraneus infection induces oxidative stress in the mollusc Mimachlamys varia

Perkinsus mediterraneus infection induces oxidative stress in the mollusc Mimachlamys varia

Digital light microscopy as a tool in toxicological evaluation of fish erythrocyte morphological abnormalities

The role of açaí ( Euterpe oleracea Mart. 1824) as a chemoprotective agent in the evaluation of antioxidant defence, oxidative damage and histology of juvenile shrimp Litopenaeus vannamei (BOONE, 1931) exposed to ammonia

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