Effects on asthma and induction of interleukin-8 caused by Asian dust particles collected in western Japan

Watanabe, Masanari; Kurai, Jun; Tomita, Katsuyuki; Sano, Hiroyuki; Abe, Satoshi; Saito, Rumiko; Minato, Sayaka; Igishi, Tadashi; Burioka, Naoto; Sako, Takanori; Yasuda, Kazuhiko; Mikami, Masayoshi; Kurita, Shinichi; Tokuyasu, Hirokazu; Ueda, Yuki; Konishi, Tatsuya; Yamasaki, Akira; Aiba, Setsuya; Oshimura, Mitsuo; Shimizu, Eiji

doi:10.3109/02770903.2014.903965

Cited by 22 publications

(19 citation statements)

References 30 publications

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“…In a previous study, we showed that airborne particles collected on days of Asian dust storms (ADSs) in western Japan had significantly different effects on induction of secretion of interleukin (IL)-8, compared to the origin soil of the ADS (Watanabe et al, 2014). We proposed that this difference may be caused by substances such as chemicals, metals and microorganisms carried by the ADS, in agreement with the findings of Honda et al (2014).…”

supporting

confidence: 72%

Definition of Asian dust particles

Watanabe

Kurai

Shimizu

2014

Environmental Research

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supporting

confidence: 72%

Definition of Asian dust particles

Watanabe

Kurai

Shimizu

2014

Environmental Research

Self Cite

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“…These cells express different receptors such as Toll-like receptors (TLRs), C-type lectin receptors (CTRs), and protease-activated receptors (PARs) that can be triggered by different toxic materials from dust particles. Following receptor-mediated signaling, epithelial cells produce pro-inflammatory cytokines, such as (interleukin(IL)-1β, IL-6, IL-8, IL-12, IL-17A interferon (IFN)-γ, TNF-α) [131][132][133]. Then, elaboration of these cytokines initiates and exacerbates a Th2-type immune response in asthmatic patients [134,135].…”

Section: Pathogeny Of Desert Dust On Respiratory Diseasesmentioning

confidence: 99%

A Systematic Review of Global Desert Dust and Associated Human Health Effects

et al. 2016

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Dust storms and sandy dust events originating in arid and semi-arid areas can transport particulate material, pollutants, and potential transport long distances from their sources. Exposure to desert dust particles is generally acknowledged to endanger human health. However, most studies have examined anthropogenic particulate sources, with few studies considering contributions from natural desert dust. A systematic literature review was undertaken using the ISI Web of Knowledge and PubMed databases with the objective of identifying all studies presenting results on the potential health impact from desert dust particles across the world. This review reveals an imbalance between the areas most exposed to dust and the areas most studied in terms of health effects. Among the human health effects of dust storms are mortality and morbidity, arising from respiratory system, circulatory system, and other diseases. We summarize the quantitative results of current scientific health research and possible pathological mechanisms, and describe some of the many challenges related to understanding health effects from exposures to desert dust particles. Overall, for respiratory and circulatory mortality, both positive and negative associations have been reported for PM 10 of desert dust, but only a positive relationship was reported between PM 2.5-10 and mortality, and a positive relationship was also reported between PM 2.5 and human mortality. Future pathological studies should continue to focus on those mechanisms causing the most harmful effect of desert dust on respiratory and cardiovascular diseases. More attention should also be paid to the association between desert dust and the morbidity of other diseases, such as those affecting the reproductive system and nervous system.

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“…Health effects of Asian dust have been a concern recently (Goudie, ; Hashizume et al, ; Zhang et al, ). Results of epidemiological studies have suggested that Asian dust exposure is associated with allergic diseases including asthma and allergic rhinitis (e.g., Chang et al, ; Kanatani et al, ; Watanabe et al., ) and with cardiovascular diseases (e.g., Kamouchi et al, ; Kashima et al, ; Kojima et al, ). In mouse models, inhalation of Asian dust particles caused increased airway inflammation (Ichinose et al, ) and aggravation of allergic rhinitis (Ichinose et al, ).…”

Section: Introductionmentioning

confidence: 99%

Dithiothreitol‐Measured Oxidative Potential of Size‐Segregated Particulate Matter in Fukuoka, Japan: Effects of Asian Dust Events

et al. 2019

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Oxidative potential is an important property of particulate matter (PM) that has been regarded as a more health‐relevant metric than PM mass. We investigated the oxidative potential of size‐segregated PM and effects of Asian dust events in Fukuoka, western Japan. Aerosol particles with diameters smaller and larger than 2.5 μm (fine and coarse particles, respectively) were collected continually from 16 March through 26 May 2016. The oxidative potential was analyzed using dithiothreitol (DTT) assay; chemical components of PM were also found. Air‐volume normalized oxidative potential quantified by DTT assay (DTTv) was significantly higher during Asian dust events than during nondust‐event days. The mean DTTv of fine and coarse particles during Asian dust events were, respectively, 1.5 and 2.7 times higher than that during nonevent days. DTTv of fine particles was highly correlated with elements dominated by anthropogenic combustion sources and with the elements emitted from multiple sources including mineral dust and combustion sources. DTTv of coarse particles strongly correlated with the mineral dust derived elements, suggesting concentration of mineral dust particles as an important controlling factor especially for the oxidative potential of the coarse particles. We estimated the contributions of water‐soluble transition metals to the oxidative potential of PM. Water‐soluble transition metals (mainly Cu and Mn) can explain only approximately 37% and 60% of the measured oxidative potential of fine and coarse particles, respectively, suggesting substantial contributions of aerosol components other than water‐soluble transition metals such as quinones and insoluble minerals.

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Effects on asthma and induction of interleukin-8 caused by Asian dust particles collected in western Japan

Abstract: Exposure to an ADS aggravates upper and lower tract respiratory symptoms in patients with adult asthma. ADS airborne particles may increase airway inflammation through enhancement of interleukin-8 transcriptional activity.

Cited by 22 publications

References 30 publications

Definition of Asian dust particles

Definition of Asian dust particles

A Systematic Review of Global Desert Dust and Associated Human Health Effects

Dithiothreitol‐Measured Oxidative Potential of Size‐Segregated Particulate Matter in Fukuoka, Japan: Effects of Asian Dust Events

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