Effects on complement activation of a new continuous autotransfusion system

Bengtsson, Anders; Avall, Anders; Tylman, M.; Wilén, G.; Bengtson, J. P.

doi:10.1046/j.1365-3148.1997.d01-12.x

Cited by 12 publications

(17 citation statements)

References 18 publications

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“…A recently developed novel device (Continuous AutoTransfusion System ® ; Fresenius TM , Bad Homburg, Germany; Figure 2) allows continuous blood processing instead of operating in batches or units 11,14 . The separation chamber used in this model represents a blood channel in the shape of a double spiral (capacity approx.…”

Section: Figurementioning

confidence: 99%

“…fat). Thus, this novel cell separator may be more efficient in clearing substances that have been difficult to remove with conventional methods 11,14 .…”

Section: Figurementioning

confidence: 99%

“…Apparently, this less traumatizing method seems to have minor detrimental effects on the shed blood, better preserving the function of red cells and platelets 8 . However, no comparative studies have been performed to date.A recently developed novel device (Continuous AutoTransfusion System ® ; Fresenius TM , Bad Homburg, Germany; Figure 2) allows continuous blood processing instead of operating in batches or units 11,14 . The separation chamber used in this model represents a blood channel in the shape of a double spiral (capacity approx.…”

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confidence: 99%

“…Blood is pumped into the inner loop, while the separation chamber rotates continuously. Substances of lower density leave the spiral immediately at this point, while RBC are moved towards the outer spiral, being continuously washed with saline 11,14,15 . All steps are performed simultaneously, allowing immediate retransfusion, even of smaller amounts, of processed red cells.…”

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confidence: 99%

“…fat). Thus, this novel cell separator may be more efficient in clearing substances that have been difficult to remove with conventional methods 11,14 .Disadvantages of cell separators might be less obvious: time and human resources are required for the setup, and the disposable single-use sets are expensive. For cases when blood loss may not be sufficient to warrant IAT operation, simple and inexpensive collection bags are available, allowing temporary storage of shed blood until further processing.…”

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Intraoperative Autotransfusion of RBC and PRP

Gombotz

Kulier

1999

Transfus Alt Transfus Med

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IntraoperativeAutotransfusion of RBC and PRP TATM 1999;3:5-13 • Intraoperative autotransfusion In addition, IP may be used when other autologous whole blood harvesting techniques are not an option. DEPARTMENT OF ANESTHESIOLOGY AND INTENSIVE CARE UNIVERSITY OF GRAZ GRAZ, AUSTRIATransfusion Alternatives in Transfusion Medicine VOLUME 1 NUMBER 3 DECEMBER 1999 Background summaryIntraoperative autotransfusion (IAT) is defined as the reinfusion of patient blood salvaged during and after surgery. IAT plays an important role in the context of perioperative blood saving strategies, having gained standard-of-care status in many surgical procedures 1,6 .The principle of IAT is to collect intraor postoperatively shed blood continuously from the operative field. The salvaged blood is aspirated from the wound site and collected in a dedicated reservoir. Under standard conditions, red cells are subsequently separated, washed, concentrated and stored for later retransfusion to the patient. Only erythrocytes are saved and retransfused; simultaneous volume and plasma replacement has to be provided, especially after processing of large quantities of shed blood 4 .In contrast to stored RBCs, freshly salvaged autologous red cells show uncompromized functional capacity, oxygen delivery to tissues and survival, indicating that IAT has no significant detrimental effects on erythrocytes 7,8 . IAT is most effective when combined with other autologous methods, particularly with preoperative autologous blood donation, acute normovolemic hemodilution or adjuvant drug therapies 4, 9, 10 . Methods Cell separation (washed blood)This technique is based on centrifugation, separating red blood cells (RBCs) from the lighter components and fluids, including plasma, saline and the buffy coat (Cell Saver, Haemolite ® , Haemonetics TM , Braintree, MA; Figure 1). Before starting the procedure, the operator must fill the system with 100-200 mL heparinized saline ("priming"), in order to prevent cells from binding to membrane surfaces initiating microaggregation, and to diminish frictional forces and damage to the cellu- Figure 1lar components 4,8 . Blood released at the wound site is aspirated via a double-lumen suction catheter (80-100 mm Hg), immediately anticoagulated (30,000 IU heparin in 1000 mL saline) at the suction tip, and stored in a plastic cardiotomy reservoir, equipped with a 120 µm microaggregate filter. When a minimum of 1000 mL shed blood is collected, it is pumped into a rotating separation chamber (Latham bowl, 225 mL adaptable capacity), washed with 1000-1500 mL saline and concentrated. Whenever the extent or kind of surgical debris requires more extensive washing, processing cycles can be selected manually, and in emergency cases, washing can be skipped entirely. For pediatric patients, smaller centrifuges are available. As soon as the preset hematocrit is reached, the spinning separator chamber stops, and packed RBCs, suspended in saline solution, are pumped into an infusion bag, while the waste products are removed 4, 11 . Afte...

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Section: Figurementioning

confidence: 99%

“…fat). Thus, this novel cell separator may be more efficient in clearing substances that have been difficult to remove with conventional methods 11,14 .…”

Section: Figurementioning

confidence: 99%

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