Effects on craniofacial growth and development of unilateral botulinum neurotoxin injection into the masseter muscle

Tsai, Cheng-Yu; Chiu, Wan‐Chun; Liao, Yi Hsuan; Tsai, Chih Mong

doi:10.1016/j.ajodo.2008.06.020

Cited by 36 publications

(45 citation statements)

References 17 publications

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“…It has become popular to inject BTX into the masseter muscle to provide an aesthetic facial contour, so there are many studies on the effects of BTX injections on muscles and bone 8,9,15 . TSAI et al found that injecting BTX into the masseter muscle in growing rats induced atrophy of the masseter muscle and morphological changes in the maxilla and mandible 20,21 . At the same time, the bone densities of the maxilla and mandible and the thickness of the cortical bone were reduced.…”

Section: Discussionmentioning

confidence: 98%

Masseter muscle fibre changes following reduction of masticatory function

Tsai

Lin

et al. 2012

International Journal of Oral and Maxillofacial Surgery

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Section: Discussionmentioning

confidence: 98%

Masseter muscle fibre changes following reduction of masticatory function

Tsai

Lin

et al. 2012

International Journal of Oral and Maxillofacial Surgery

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“…40 anthropometric parameters were analyzed ( Fig. 1a and b) as described by LEVRINI et al 11 , YAMAMOTO 29 , ULGEN et al 28 , TSAI and LIAO 27 , and MATIC et al 12 .…”

Section: Methodsmentioning

confidence: 99%

“…Basic scientific research with BoNT/A is limited 27 , and its full anatomical effects are not known, particularly with regard to the mandible and relevant anthropometric measurements. The purpose of this study was to evaluate the influence of the musculature on the craniofacial skeleton in a growing animal model by inducing localized masticatory atrophy and paresis.…”

mentioning

confidence: 99%

The influence of masticatory hypofunction on developing rat craniofacial structure

Tsai¹,

Yang²,

Chen³

et al. 2010

International Journal of Oral and Maxillofacial Surgery

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“…The key role of masticatory muscle hypertonus in development of TMJ pain dysfunction syndrome is reflected widely in the literature [5,24,26,27,47,56,58]. Disc dislocation and muscle symptoms are the most frequent diagnosed signs of craniomandibular disorder [33,34].…”

Section: Introductionmentioning

confidence: 99%

“…Main causes of bruxism are psychological stress factors of the patient [55]. Stress often leads to an increased muscle fibre activity in chewing muscles [33,37,43,50,56].…”

Section: Introductionmentioning

confidence: 99%

Therapeutic application of Botulinum Toxin A in patients with local muscle dystonia and oral dyskinesia

Orlova

Soikher²,

Сойхер³

et al. 2010

J. Stomat. Occ. Med.

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Botulinum Toxin Type A has been introduced as new therapeutic regime in neurological, cosmetic, urinary, gastrointestinal and pain-related conditions. The use of Botulinum Toxin A in craniomandibular disorders is discussed controversially.Local muscle dystonia is defined as movement disorder in combination with sustained muscle contractions. Contortion, repetitive movements and atypical posture are frequently seen symptoms in such cases. The movements are involuntary and often painful. A single muscle or a group of muscles, even the whole body may be involved. Oral dyskinesias are involuntary repetitive movements of the mouth and face. Severe bruxism can be included in this form of movement disorder.Within this study, patients diagnosed with severe bruxism or local muscle dystonia including oral dyskinesia were examined with electromyography before and after treatment. Subjects were randomly allocated to either myo-relaxation medication and relaxation splint therapy or to Botulinum Toxin A injection therapy. Surface EMG parameters of chewing and neck muscles were used to judge the treatment effects. A positive impact of BTA on EMG-characteristics, reflecting the functional condition of facial muscles, had been detected. BTA injections seem to have a positive effect in patients with bruxism and local muscle dystonia. An increased quantity of mandibular movements and a better coordination can be observed after BTA injection. In comparison with a standard myo relaxation therapy, the effects of BTA treatment are more distinct and long standing.BTA appears to be a promising therapeutic regime in patients with focal muscle dystonia and oral dyskinesia. A confirmed diagnosis and lege artis application by experienced clinicians constitute as sine qua non. Further studies are required to improve our knowledge in Botulinum Toxin A treatment of muscle dystonia and dyskinesia.

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Effects on craniofacial growth and development of unilateral botulinum neurotoxin injection into the masseter muscle

Cited by 36 publications

References 17 publications

Masseter muscle fibre changes following reduction of masticatory function

Masseter muscle fibre changes following reduction of masticatory function

The influence of masticatory hypofunction on developing rat craniofacial structure

Therapeutic application of Botulinum Toxin A in patients with local muscle dystonia and oral dyskinesia

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