Effects on Productivity and Quality of Life of Rizatriptan for Acute Migraine: A Workplace Study

Láinez, Miguel J. A.; López, Arturo Bados; Pascual, Ana

doi:10.1111/j.1526-4610.2005.05156.x

Cited by 28 publications

(46 citation statements)

References 25 publications

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“…Limited evidence exists that symptomatic medications, such as Almotriptan [26] and Rizatriptan [31], improve patient vitality. Limited evidence also exists about the utility of Topiramate in improving vitality [32] and reducing fatigue [33] as well as of other prophylactic agents, including antiepileptics, antidepressants, neuroleptics, and beta-blockers in improving vitality [29].…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

A systematic review of the psychosocial difficulties relevant to patients with migraine

Raggi¹,

Giovannetti²,

Quintas³

et al. 2012

J Headache Pain

108

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Migraine is a common disease which causes significant burden to individuals, in terms of personal suffering and activity reduction, and to societies, in terms of disease cost. The purpose of this study is to identify the most relevant psychosocial difficulties related to migraine, the variables associated with them and the most relevant determinants of their evolution over time. MEDLINE and PsychINFO were searched for studies published in English between 2000 and 2010 that examined psychosocial difficulties in persons with migraine with and without aura, from clinical trials and observational studies. Information on the description of each difficulty, its determinants of onset and change over time and associated variables were extracted and categorized at a higher level. In total, 34 difficulties have been collected from 51 papers: the most frequent were reduced vitality and fatigue, emotional problems, pain, difficulties at work, general physical and mental health, social functioning and global disability. Evidence exists that pharmacological treatments have an impact toward improvement in patients’ difficulties, in particular emotional problems, physical and mental health, difficulties with employment and global disability. Migraine treatments and decreased headaches frequency are the major determinants of improvements in psychosocial difficulties, while no information is available for determinants of worsening; understanding the role of such factors is of primary public health relevance, given the high prevalence and the relevant personal and societal costs of migraine.Electronic supplementary materialThe online version of this article (doi:10.1007/s10194-012-0482-1) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

“…Limited evidence exists about the positive impact of prophylactic medications, such as Topiramate [32] and Botulinum Toxin type A [33], and symptomatic medications, such as Rizatriptan [31], Sumatriptan and Naproxen Sodium [42] on pain reduction.…”

Section: Resultsmentioning

confidence: 99%

A systematic review of the psychosocial difficulties relevant to patients with migraine

Raggi¹,

Giovannetti²,

Quintas³

et al. 2012

J Headache Pain

108

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“…SF-36 and MSQ were found to be able to demonstrate improvement following repetitive administration of triptans in open trials (186)(187)(188).…”

Section: Health-related Quality Of Life (Ability To Function In Dailymentioning

confidence: 99%

Guidelines for controlled trials of drugs in migraine: Third edition. A guide for investigators

Tfelt‐Hansen

Pascual

Ramadan³

et al. 2012

Cephalalgia

322

213

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“…Most of the studies were financially sponsored by Merck Frosst, the maker of rizatriptan. 3,4,[6][7][8]10,[12][13][14][15] This bias likely resulted in the preference comparison of rizatriptan to the 50 mg dose of sumatriptan, rather than the 100 mg dose, which may be more effective than the lower dose of sumatriptan in some patients. 26 Furthermore, most studies compared only two attacks -one attack for each medication -which may not be enough time to determine whether a medication is effective and well tolerated.…”

Section: Discussionmentioning

confidence: 99%

“…A different type of study by Láinez and colleagues 15 looked at productivity and quality of life, as well as preference for rizatriptan over usual medications. This was a prospective, open-label study at 27 work sites in Spain.…”

mentioning

confidence: 99%

Rizatriptan for the acute treatment of migraine: Consistency, preference, satisfaction, and quality of life

Amoozegar

Pringsheim

2009

PPA

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Patient Preference and AdherenceAbstract: Rizatriptan is a 5HT (IB/ID) agonist with proven efficacy in the acute treatment of migraine headache. We performed a systematic review of the literature for clinical trials of rizatriptan incorporating important patient outcomes including consistency of response, preference, satisfaction, and quality of life. We found evidence that rizatriptan provides consistent relief of migraine attacks and that patients prefer rizatriptan over other treatments because of its speed of relief. Patient satisfaction with rizatriptan is significantly higher than placebo, but appears equivalent to most other triptans. Migraine-specific quality of life at 24 hours is significantly better in patients treated with rizatriptan compared to placebo, while overall long-term quality of life is less affected. The published clinical trials included in this systematic review are subject to bias due to the open-label nature of preference trials and the doses chosen for comparison in head-to-head trials.

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Effects on Productivity and Quality of Life of Rizatriptan for Acute Migraine: A Workplace Study

Cited by 28 publications

References 25 publications

A systematic review of the psychosocial difficulties relevant to patients with migraine

A systematic review of the psychosocial difficulties relevant to patients with migraine

Guidelines for controlled trials of drugs in migraine: Third edition. A guide for investigators

Rizatriptan for the acute treatment of migraine: Consistency, preference, satisfaction, and quality of life

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