Effervescent Tablets: Everything You Need To Know

Abstract

Oral dosage forms are the most popular way of taking medication, despite having some disadvantages compared with other methods like risk of slow absorption of the medicament, which can be overcome by administering the drug in liquid form, therefore, possibly allowing the use of a lower dosage. However, instability of many drugs in liquid dosage form limits its use. Effervescent technique can be used as alternate to develop a dosage form which can accelerate drug disintegration and dissolution, is usually applied in quick release preparations. Along with the development of new pharmaceutical technique, effervescent tablets are more and more extensively to adjust the behavior of drug release, such as in sustained and controlled release preparations, pulsatile drug delivery systems, and so on. In this review we have discussed about formulation, evaluation, advantages of effervescent tablets and also demonstrated the new applying of effervescent technique in effervescent tablets. Keywords: Effervescent tablets. Carbon tablet, Effervescent granules.

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“…According to US-FDA, when sodium-bicarbonate and citric acid mix together; react rapidly in water and release CO 2 ; release of CO 2 enhances the dissolution of active pharmaceutical ingredient. (Lodhi et al, 2022) Packaging material of effervescent system There are some complexities in controlling the atmospheric conditions particularly RH and temperature; which degrade effervescent product. During manufacturing; product should be protected from unwanted effervescent reaction between acidic and basic medium; specialized package is also required to maintain product stability throughout its shelf-life, which further increases the cost of product.…”

A Comprehensive Review on Effervescent Tablets

“…81 This density can be obtained by dividing the mass of the powder by its total volume., including the spaces between particles. 82 It is an important factor in the development of effervescent dosage forms as it affects flow properties, compressibility, and rate of dissolution. Measuring the bulk density ensures consistent dosing and optimal packaging.…”

“…The test is carried out in triplicate, and the results are compared to the relevant quality and efficacy requirements. 82 7. pH of the solution:…”