Effervescent vitamin C tablets and its quality control

Abstract

Ascorbic acid (vitamin C), a potent antioxidant, is not synthesized by the human body and is obtained from food and pharmaceutical formulations. As a pharmaceutical product, it is available as a solution, powder, granules and tablets. Effervescent tablets are the most consumed since the isolated form or associated with other substances. It is commercially available from several suppliers, which makes its evaluation fundamental to ensure the quality, efficacy and safety of the patient in face of over-the-counter medication. Quality control is essential in the final product, as many products do not have the desired quality, compromising its validity and action. The present study aimed to evaluate effervescent vitamin C tablets from three different brands. The quality tests were carried out according to the parameters recommended by the Brazilian Pharmacopeia. The content was determined by the titrimetric and spectrophotometric method, as there is no official methodology for effervescent vitamin C tablets. All brands were approved in the quality tests used, guaranteeing and demonstrating the company's commitment to the population that consumes it.

Hyperspectral and Microtomographic Analyses to Evaluate the Stability of Quercetin and Calcium Effervescent Tablets Exposed to Heat and Ultraviolet Radiation

“…A small amount of moisture can lead to an interaction that depends on the affinity of the solid to bind moisture, the strength of the bond, the functional groups present on the surface of the solid, and the exposed surface [48]. To prevent this, their production takes place under controlled hygrothermal conditions (relative humidity below 20%, at 25 • C) and the final product is packaged in containers containing a moisture absorber or foil pouches [46,49].…”

Controle de qualidade de comprimidos efervescentes de vitamina C comercializados no município de Manaus - AM

“…Os comprimidos efervescentes são formulações que contém sais efervescentes granulados que ao entrar em contato com o líquido liberam dióxido de carbono, dessa forma, é necessário serem diluídos para assim serem administrados (Oliveira et al, 2020). Segundo Alemad et al (2020), os efervescentes possuem características vantajosas quando comparados a outras formas farmacêuticas, por apresentar rápida dissolução, redução da percepção de sabores desagradáveis e facilidade de administração, além da alta biodisponibilidade da droga.…”