Effet de l’exposition chronique au nickel sur les fonctions neurocomportementales chez les rats Wistar pendant la période de développement

Khaled, K.F.; Adli, Djallal Eddine Houari; Slimani, Miloud; Terras, Halima; Achour, S.

doi:10.1016/j.toxac.2014.09.056

Cited by 16 publications

(10 citation statements)

References 28 publications

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“…Our data also showed that 1 mg/kg of Ni produced higher depression-like behavior in male and female rats. This result was in accordance with the study of Kahloula et al, reporting that depression-like behavior was significantly increased by Ni treatment during the development period [ 10 ]. Interestingly, Mel administration (4 mg/kg) showed a significant anxiolytic effect in Ni treated rats as revealed in OF and EPM tests.…”

Section: Discussionsupporting

confidence: 93%

“…Our results also revealed that the chronic administration of Ni causes learning and memory deficits in the MWM test, confirming our previous findings [13]. These results were parallel to a previous report on the association of Ni exposure with memory impairment assessed in the MWM [10]. In the study of He et al, in Mice, acute intoxication with Ni at 5 and 50 mg/kg increased the escape latency in the MWM [9].…”

Section: Discussionsupporting

confidence: 92%

“…The same effects were observed in an evaluation of workers welding high-Ni alloys, exposed for six weeks to Ni fumes (0.07 to 1.1 mg Ni/m3) [ 8 ]. In animal studies, Ni exposure induced aggressive behavior, emotional changes, and cognitive problems [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

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Neuroprotective effect of melatonin on nickel-induced affective and cognitive disorders and oxidative damage in rats

Lamtai

Ouakki

Zghari

et al. 2020

Environ Anal Health Toxicol

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The present work is carried out to explore the neuroprotective potential of Melatonin(Mel), on Ni-induced neurobehavioral, biochemical and histological alterations in male and female rats. The rats were intraperitoneally administered by nickel chloride (NiCl2, 1 mg/kg) and Mel (4 mg/kg) for 60 days. A neurobehavioral assessment was performed. Biochemical determinations of oxidative stress (OS) levels, and histological analysis of hippocampal tissues were also performed. Results showed that Nickel (Ni) treatment increased anxiety-like and depression-like behavior in rats. Besides, cognitive behavior on the Morris water maze was compromised following Ni treatment. Alongside this, Ni elevated hippocampal OS markers like lipid peroxidation and nitric oxide formation with a decrease in superoxide dismutase and catalase activities. Histological observations confirmed these results. Significantly, Mel administration alleviated neurobehavioral changes in Ni-treated rats of both genders. Also, Mel attenuated Ni-induced OS and increased the activities of antioxidant enzymes. The histopathological studies in the hippocampus supported that Mel markedly reduced the Ni-induced neuronal loss. In conclusion, this study suggests that Mel has a neuroprotective effect against Ni-induced neurobehavioral alterations, which may be related to lowering OS in the hippocampus.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

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Neuroprotective effect of melatonin on nickel-induced affective and cognitive disorders and oxidative damage in rats

Lamtai

Ouakki

Zghari

et al. 2020

Environ Anal Health Toxicol

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“…On day 5, rats were tested for spatial memory in a 60 s probe trial with no platform present and after 2 hours rats were tested (four trials) using a visible platform, which was placed in the Northwest quadrant [15].…”

Section: Cognitive Measurementmentioning

confidence: 99%

Effect of Chronic Aluminum Administration on Affective and Cognitive Behavior in Male and Female Rats

Zghari¹,

Rezqaoui²,

Ouakki³

et al. 2018

JBBS

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In this study, we investigated the effect of chronic exposure of low doses of Aluminum on affective and cognitive disorders in male and female rats. Twenty-five rats for each gender are used and the treatment carried out for 8 weeks. Animals received distilled water for control or an intraperitoneal injection of different doses of Aluminum: 0.125, 0.25, 0.5 and 1 mg/kg. Behavioral performance is measured in various tests mainly the Open Field, Elevated Plus Maze, Force Swimming Test, Morris Water Maze, Y-maze and Object Recognition Test. Al exerts anxiogenic properties and depressive effect. The effect begins at 0.25 mg/kg to reach a maximum at 1 mg/kg. In addition, chronic exposure to Aluminum causes cognitive disorders characterized by affection of memory and influence spatial learning performance. The effect of Aluminum on working memory is effective just at 1 mg/kg, while the effect on spatial learning performance begins at 0.25 mg/kg to reach a maximum at 1 mg/kg. In conclusion, Aluminum enhances anxiety and depression parameters and cognitive disorders characterized by the affection of memory and spatial learning performance.

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“…It is known that changes in neurochemistry often correlate with behavioral disturbance [ 17 ]. Animal studies have shown that Ni exposure leads to increased aggressive behavior and affective disorders, and impaired memory processes and exploring activity [ 11 , 18 ]. It has been also demonstrated that Ni has a neuromodulatory role; it can interfere with acetylcholine release from peripheral nerve terminals in vitro [ 19 ] and decrease dopamine, norepinephrine, and serotonin levels in certain rat brain regions and change the gene expression of the glutamate receptors [ 7 , 16 , 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Chronic Administration of Nickel on Affective and Cognitive Behavior in Male and Female Rats: Possible Implication of Oxidative Stress Pathway

et al. 2018

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Nickel (Ni) toxicity has been reported to produce biochemical and behavioral dysfunction. The present study was undertaken to examine whether Ni chronic administration can induce alterations of affective and cognitive behavior and oxidative stress in male and female rats. Twenty-four rats, for each gender, divided into control and three test groups (n = 6), were injected intraperitoneally with saline (0.9% NaCl) or NiCl2 (0.25 mg/kg, 0.5 mg/kg and 1 mg/kg) for 8 weeks. After treatment period, animals were tested in the open-field, elevated plus maze tests for anxiety-like behavior, and forced swimming test for depression-like behavior. The Morris Water Maze was used to evaluate the spatial learning and memory. The hippocampus of each animal was taken for biochemical examination. The results showed that Ni administration dose dependently increased anxiety-like behavior in both tests. A significant increase in depression-like symptoms was also exhibited by Ni treated rats. In the Morris Water Maze test, the spatial learning and memory were significantly impaired just in males treated with 1 mg/kg of Ni. With regard to biochemical analysis, activity of catalase (CAT) and superoxide dismutase (SOD) were significantly decreased, while the levels of nitric oxide (NO) and lipid peroxidation (LPO) in the hippocampus were significantly increased in the Ni-treated groups. Consequently, chronic Ni administration induced behavioral and biochemical dysfunctions.

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Effet de l’exposition chronique au nickel sur les fonctions neurocomportementales chez les rats Wistar pendant la période de développement

Cited by 16 publications

References 28 publications

Neuroprotective effect of melatonin on nickel-induced affective and cognitive disorders and oxidative damage in rats

Neuroprotective effect of melatonin on nickel-induced affective and cognitive disorders and oxidative damage in rats

Effect of Chronic Aluminum Administration on Affective and Cognitive Behavior in Male and Female Rats

Effect of Chronic Administration of Nickel on Affective and Cognitive Behavior in Male and Female Rats: Possible Implication of Oxidative Stress Pathway

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