Effets de la macro et de la nano-géométrie sur la stabilité primaire des implants

Bhola, Monish

doi:10.1051/sfmbcb/20125901003

Cited by 1 publication

(1 citation statement)

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“…As osseointegration is not only conditioned by the intrinsic nature of the materials, the surface chemistry and properties are essential in this process, influencing the protein adsorption and osteoblastic cell adhesion [27]. For instance, well-documented studies based on titanium implants have highlighted the importance of roughness to promote osseointegration, favoring both bone anchoring and biomechanical stability [28,29].…”

Section: Introductionmentioning

confidence: 99%

Biocompatibility of ZrO2 vs. Y-TZP Alloys: Influence of Their Composition and Surface Topography

et al. 2022

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The osseointegration of implants is defined as the direct anatomical and functional connection between neoformed living bone and the surface of a supporting implant. The biological compatibility of implants depends on various parameters, such as the nature of the material, chemical composition, surface topography, chemistry and loading, surface treatment, and physical and mechanical properties. In this context, the objective of this study is to evaluate the biocompatibility of rough (Ra = 1 µm) and smooth (Ra = 0 µm) surface conditions of yttria–zirconia (Y-TZP) discs compared to pure zirconia (ZrO2) discs by combining a classical toxicological test, morphological observations by SEM, and a transcriptomic analysis on an in vitro model of human Saos-2 bone cells. Similar cell proliferation rates were observed between ZrO2 and Y-TZP discs and control cells, regardless of the surface topography, at up to 96 h of exposure. Dense cell matting was similarly observed on the surfaces of both materials. Interestingly, only 110 transcripts were differentially expressed across the human transcriptome, consistent with the excellent biocompatibility of Y-TZP reported in the literature. These deregulated transcripts are mainly involved in two pathways, the first being related to “mineral uptake” and the second being the “immune response”. These observations suggest that Y-TZP is an interesting candidate for application in implantology.

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Section: Introductionmentioning

confidence: 99%