Effets des glucocorticostéroïdes sur l'activité des enzymes du cycle de l'urée dans le foie foetal de rat

Gautier, C.; Husson, Annie; Vailiant, René

doi:10.1016/s0300-9084(77)80091-6

Cited by 28 publications

(27 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our first results show that the mitochondrial level of immunoreac tive CPS-I increases after hydrocortisone acetate supply (unpublished data). Concerning OTC activity, these results are apparently inconsistent with our previous re ports [4,5]. The development of the enzyme needs the presence of adrenals, while an ex cess of hydrocortisone acetate decreases its activity.…”

Section: Discussioncontrasting

confidence: 92%

“…Our ear lier studies showed that the activities of CPS-I and OTC are low in the fetus and increase rapidly after birth [4], We also reported that both activities are affected by the deprivation of glucocorticoids during the late fetal period [5]. Moreover, a hydrocortisone acetate sup ply to intact fetuses increased the level of CPS-I activity 3 days later, while OTC activ ity exhibited a paradoxical increase after an actinomycin D supply [6].…”

Section: Introductionmentioning

confidence: 56%

“…Between 18.5 and 21.5 days of pregnancy, the hormone supply pre maturely increases CPS-I activity (about 36%) and decreases the OTC activity (about 23%). However, it was previously reported that the development of these enzyme activi ties was dependent upon the presence of glu cocorticoids [4,5]. Concerning CPS-I activi ty, it is concluded that its maturation is strongly bound to the presence of glucocorti coids.…”

Section: Discussionmentioning

confidence: 91%

See 2 more Smart Citations

Effects of Corticosteroids and Pancreatic Hormones on Carbamyl Phosphate Synthetase-I and Ornithine Transcarbamylase Activities in Fetal Rat Liver

Gautier¹,

Habechi²,

Belbekouche³

et al. 1985

Neonatology

View full text Add to dashboard Cite

The effects of corticosteroids and pancreatic hormones on two mitochondrial enzymes of ureagenesis, carbamyl phosphate synthetase-I (CPS-I) and ornithine transcarbamylase (OTC), were investigated and compared in fetal rat liver. Supplementing hydrocortisone acetate (50 μg) to 18.5-day-old fetuses significantly increased CPS-I activity (by 36%) and decreased OTC activity (by 23%). An actinomycin D supply (2 μg) to 18.5-day-old fetuses prematurely increased OTC activity and decreased fetal insulin level (by 42%). This treatment had no effect on CPS-I activity. Glucagon supply (25 μg) during the late fetal period increased both activities within 2 h, while dibutyryl-cAMP enhanced OTC activity 17 h later. These results suggested that the fetal development of CPS-I activity was under the control of corticosteroids and glucagon. In contrast, corticosteroid hormones produced an inhibitory effect on OTC activity. This might be explained by the permissive effect of corticosteroids on insulin action, since insulin might act as a repressor in utero of enzyme development. Thus, the paradoxical effect of actinomycin D on OTC activity was probably due to the decrease in fetal insulinemia.

show abstract

Section: Discussioncontrasting

confidence: 92%

Section: Introductionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 91%

See 1 more Smart Citation

Effects of Corticosteroids and Pancreatic Hormones on Carbamyl Phosphate Synthetase-I and Ornithine Transcarbamylase Activities in Fetal Rat Liver

Gautier¹,

Habechi²,

Belbekouche³

et al. 1985

Neonatology

View full text Add to dashboard Cite

show abstract

“…During the course of an investigation of the regulation of urea cycle enzyme activities in fetal liver, it was shown, in general agree ment with other authors [ 10,18], that the five enzyme activities appeared on day 17.5 in fetal rat liver, rose slowly until birth and then rapidly increased during the first postnatal day [5]. These data suggested that urea syn thesis could occur in fetal tissue at a relatively early stage.…”

Section: Introductionsupporting

confidence: 83%

“…These data suggested that urea syn thesis could occur in fetal tissue at a relatively early stage. It was then demonstrated that all the urea cycle enzyme activities were affected by deprivation of glucocorticosteroids during the late fetal period [5] or just after birth [? ).…”

Section: Introductionmentioning

confidence: 99%

Control of Urea Synthesis in Fetal Rat Liver Slices

Husson¹,

Fairand²,

Vaillant³

1981

Neonatology

View full text Add to dashboard Cite

Urea synthesis in fetal rats was studied using a liver slice system with ammonium chloride as nitrogen source. In term fetuses, the rate of urea formation increases with ammonium chloride concentration up to 100 μM and is enhanced by the addition of ornithine. The developmental pattern for urea synthesis is very similar to that found in the enzyme activity studies: urea production increases slightly during fetal life and then rises rapidly at birth. It is found that fetal liver has an absolute requirement for glucocorticosteroids to develop a normal urea synthesis. The accordance with argininosuccinate synthetase activity measured in liver homogenate is discussed.

show abstract

Glucocorticoids and Differentiation

Ballard¹

1979

Glucocorticoid Hormone Action

View full text Add to dashboard Cite

Effets des glucocorticostéroïdes sur l'activité des enzymes du cycle de l'urée dans le foie foetal de rat

Cited by 28 publications

References 18 publications

Effects of Corticosteroids and Pancreatic Hormones on Carbamyl Phosphate Synthetase-I and Ornithine Transcarbamylase Activities in Fetal Rat Liver

Effects of Corticosteroids and Pancreatic Hormones on Carbamyl Phosphate Synthetase-I and Ornithine Transcarbamylase Activities in Fetal Rat Liver

Control of Urea Synthesis in Fetal Rat Liver Slices

Glucocorticoids and Differentiation

Contact Info

Product

Resources

About