Effets hypotensifs de l'extrait au méthanol de Bidens pilosa Linn chez les rats hypertendus

Dimo, Théophile; Nguelefack, Télesphore Benoît; Kamtchouing, Pièrre; Dongo, Étienne; Rakotonirina, A.; Rakotonirina, S.V.

doi:10.1016/s0764-4469(99)80068-7

Cited by 33 publications

(31 citation statements)

References 6 publications

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“…It indicates the presence of cholinomimetics substances in this crude extract. These results, comparable to those obtained by Dimo et al (1999) with Bidens pilosa (Asteraceae), Abo et al (2000) with Mareya micrantha (Euphorbiaceae) and Konan et al (2006) with Sesamum radiatum (Pedaliaceae), Atsamo et al (2013) on Erythrina senegalensis and Boua et al (2013) on Turraea heterophylla, demonstrates the presence of cholinomimetics substances in the aqueous extract of Picralima nitida.…”

Section: Discussionsupporting

confidence: 84%

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Phytochemical and Toxicological Studies of an Extract of the Seeds of Picralima Nitida (Stapf) (Apocynaceae) and Its Pharmacological Effects on the Blood Pressure of Rabbit

N’dri

Nene-Bi

Zahoui

et al. 2015

JBLS

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The phytochemical screening of the seeds extracts of Picralima nitida has highlighted the presence of alkaloids and terpenes poly sterols in chloroform solutions, methanol and in the aqueous. Unlike chloroform and methanol solutions, the aqueous revealed the presence of saponins. An acute toxicity study in mice showed that the aqueous extract of Picralima nitida would be slightly toxic with a lethal dose (LD) 50 % of 9120.11 mg/kg of body weight (bw). This extract, in rabbits induced a dose-dependent hypotension for the doses between 3.10 -6 g / kg bw and 2.10 -5 g/kg bw with an effective dose 50% (ED50) equal to 4.07×10 -6 g/kg bw. In the presence of atropine (6.10 -9 g/kg), a competitive inhibitor of acetylcholine, the hypotensive effect of aqueous extract of Picralima nitida is reduced, confirming in this extract the presence of cholinomimetics substances of muscarinic type. The results therefore suggest the presence of cholinomimetics substances in the aqueous extract of Picralima nitida seed. These substances could be responsible for the hypotensive effect of this extract. The same extract did not induce diuresis in rats.

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Section: Discussionsupporting

confidence: 84%

“…If the hypotensive effect of the crude extract of Picralima nitida was demonstrated, this extract does not seem to have diuretic effect like the extracts of Bidens pilosa (Dimo et al, 1999) and Bridelia ferruginea (Nene Bi et al, 2012;. ISSN 2157-6076 2015 …”

Section: Discussionmentioning

confidence: 99%

Phytochemical and Toxicological Studies of an Extract of the Seeds of Picralima Nitida (Stapf) (Apocynaceae) and Its Pharmacological Effects on the Blood Pressure of Rabbit

N’dri

Nene-Bi

Zahoui

et al. 2015

JBLS

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“…In previous reports the antihypertensive effect of lyophilized aqueous and methanol leaf extracts of B. pilosa using unanaesthetized rats have been studied. In unanaesthetized rats, it has been found that the aqueous (Dimo et al, 1996) and methanol (Dimo et al, 1999) leaf extracts exhibit antihypertensive action. It has also been shown that the leaf aqueous extract of B. pilosa has a vasorelaxant activity (Dimo et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Possible mechanisms of action of the neutral extract from Bidens pilosa L. leaves on the cardiovascular system of anaesthetized rats

Dimo

Nguelefack

Tan

et al. 2003

Phytotherapy Research

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The aim of this study was to investigate the hypotensive and cardiac effects of the neutral extract from Bidens pilosa leaves. Intravenous administration of the extract resulted in a biphasic dose-related hypotensive activity. In normotensive rats (NTR), B. pilosa decreased systolic blood pressure by 18.26%, 42.5% and 30% at doses of 10, 20 and 30 mg/kg, respectively. In spontaneously hypertensive rats (SHR), the decrease in systolic blood pressure was 25.77%, 38.96% and 28.64% at the above doses, respectively. These doses induced hypotension by 27%, 34.13% and 18.73% respectively in salt-loaded hypertensive rats. In NTR, B. pilosa reduced heart rate by 23.68% and 61.18% at doses of 20 and 30 mg/kg, respectively. The force of contraction of the heart was only affected at 30 mg/kg. The initial phase of hypotensive response was partially inhibited by atropine while propranolol increased this effect. These results suggest that B. pilosa exhibited its fi rst hypotensive effects by acting on the cardiac pump efficiency and secondly through vasodilation.

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“…It is empirically used, as a decoction, for the treatment of various illnesses: in Cameroon for example, it is used for the management of hypertension (Dimo et al, 1999), in Taiwan for anti-oedemic and antiinflammatory activity (Duke, 1997). Difficult access to conventional drugs in low/middle income countries, like Cameroon, favours the use of medicinal plants for the management of cardiovascular diseases and oxidative stress and B. pilosa has been extensively studied for those properties (Dimo et al, 1999(Dimo et al, , 2002Chiang et al, 2004). In addition, the plant is used for curing many other diseases in and out of Cameroon (Dimo et al, 2002;Ezeonwumelu et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Sub-chronic toxicity of the leaf aqueous extract of Bidenspilosa Linn (Asteraceae) in male and female rats

Bopda¹,

Longo²,

Boade³

et al. 2016

J. Med. Plants Res.

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Bidens pilosa is used empirically for the treatment of various illnesses among which are: jaundice, conjunctivitis, cataract, malaria, ulcers and hypertension. This study is aimed at evaluating the subchronic toxicity of the leaf aqueous extracts of B. pilosa. The effects of the administration of the aqueous extracts of B. pilosa on physical (body weight, relative weight of organs), biochemical and histological parameters were studied in male and female albino Wistar rats. Daily doses of extract (100, 500 and 1000 mg/kg) and distilled water were administered orally for 4 weeks; during which signs of toxicity were checked. At the end of the experiments, the rats were sacrificed, their blood and organs collected for biochemical, histological and haematological analyses. No death was recorded. At the end of the treatment, there were no significant (P>0.05) variations of the body weight gain and the relative weights of detoxification organs (liver and kidney). The analysis of biochemical parameters showed a significant (p<0.001) variation of serum levels of ALT and creatinin. Histological analysis of liver and kidney, revealed no modification. The analysis of haematological parameters showed no significant difference between males and females, overall. However, when considering each sex in particular, it was observed that in males red blood cell distribution width-coefficient variation (RDWcv) significantly increased at the doses of 500 mg/kg (P=0.02) and 1000 mg/kg (P=0.04) (vs. control). Unlike in males, white blood cells (WBC) in females decreased significantly at 500 (P=0.01) and 1000 mg/kg (P=0.01) (vs. control). It can be concluded that Bidenspilosa has a relatively low toxic effects in both sexes, with some gender differences in the haematological results.

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Effets hypotensifs de l'extrait au méthanol de Bidens pilosa Linn chez les rats hypertendus

Cited by 33 publications

References 6 publications

Phytochemical and Toxicological Studies of an Extract of the Seeds of Picralima Nitida (Stapf) (Apocynaceae) and Its Pharmacological Effects on the Blood Pressure of Rabbit

Phytochemical and Toxicological Studies of an Extract of the Seeds of Picralima Nitida (Stapf) (Apocynaceae) and Its Pharmacological Effects on the Blood Pressure of Rabbit

Possible mechanisms of action of the neutral extract from Bidens pilosa L. leaves on the cardiovascular system of anaesthetized rats

Sub-chronic toxicity of the leaf aqueous extract of Bidenspilosa Linn (Asteraceae) in male and female rats

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