“…Of the 25 studies that have published ISDR sequences from IFN resistant and IFNsensitive viruses, nine support the Enomoto model and conclude that, at the 5% significance level, the data provide sufficient evidence that IFN-response and substitutions in the ISDR are dependent [Enomoto et al, 1995[Enomoto et al, , 1996Chayama et al, 1997;Kurosaki et al, 1997;Fukuda et al, 1998;Saiz et al, 1998;Murashima et al, 1999;Sarrazin et al 1999;Sakuma et al, 1999]. The other 16 studies were unable to conclude that there is a correlation [Hofgartner et al, 1997;Khorsi et al, 1997;Squadrito et al, 1997;Zeuzem et al, 1997;Duverlie et al, 1998;Franguel et al, 1998;Odeberg et al, 1998;Pawlotsky et al, 1998;Polyak et al, 1998;Rispeter et al, 1998;Chung et al, 1999;Sarrazin et al 1999;Squadrito et al, 1999;Ibarrola et al, 1999;Mihm et al, 1999;Arase et al, 1999].…”