Efficacy and cognitive side effects of tiagabine and topiramate in patients with epilepsy

Fritz, N.E.; Glogau, S.; Hoffmann, Judith M.; Rademacher, Michael; Elger, Christian E.; Helmstaedter, C.

doi:10.1016/j.yebeh.2005.01.002

Cited by 139 publications

(88 citation statements)

References 31 publications

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“…With some drugs, such as topiramate, sparsity of language production is a recognized and sometimes drastic side effect. 34 It is possible that the antiepileptic drugs, taken by our refractory patients, were causing changes in resting-state functional connectivity. However, at least some medicated patients showed prominent language connectivity, arguing against the notion that antiepileptic drugs are the sole explanation for our findings.…”

Section: Suppression Of Resting-state Activity By Antiepileptic Medicmentioning

confidence: 97%

Functional connectivity networks are disrupted in left temporal lobe epilepsy

Waites

Briellmann

Saling

et al. 2006

Annals of Neurology

290

212

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Section: Suppression Of Resting-state Activity By Antiepileptic Medicmentioning

confidence: 97%

Functional connectivity networks are disrupted in left temporal lobe epilepsy

Waites

Briellmann

Saling

et al. 2006

Annals of Neurology

290

212

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“…Tiagabine A few CAEs have been reported with the use of tiagabine, such as deterioration in verbal memory from 3 months after baseline tests [Fritz et al 2005]. However, some studies, including double-blind, placebo-controlled trials, have reported no negative impact on cognition [Aikiä et al 2006;Dodrill et al 1997;Kälviäinen et al 1996;Sveinbjornsdottir et al 1994].…”

Section: Sodium Valproate and Ethosuximidementioning

confidence: 99%

“…Cognitive side effects can include impaired concentration [Froscher et al 2005], cognitive dulling [Coppola et al 2002], psychomotor slowing [Tatum et al 2001], language and comprehension problems [Fritz et al 2005], detrimental effects on short-term memory [Gomer et al 2007;Aldenkamp et al 2000] and working memory [Jung et al 2010;Lee et al 2006;Fritz et al 2005], poor verbal fluency [Jung et al 2010;Gomer et al 2007;Lee et al 2006Lee et al , 2003Fritz et al 2005;Thompson et al 2000] and wordfinding deficits [Mula et al 2003b], reduced IQ score [Sun et al 2008;Lee et al 2003;Thompson et al 2000] and cognitive speed [Bootsma et al 2008a;Gomer et al 2007], and abnormal thinking [Froscher et al 2005]. Other studies report improvements in cognitive measures after topiramate withdrawal [Kockelmann et al 2003].…”

Section: Pregabalinmentioning

confidence: 99%

The cognitive impact of antiepileptic drugs

Eddy¹,

Rickards²,

Cavanna³

2011

Ther Adv Neurol Disord

325

189

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Effective treatment of epilepsy depends on medication compliance across a lifetime, and studies indicate that drug tolerability is a significant limiting factor in medication maintenance. Available antiepileptic drugs (AEDs) have the potential to exert detrimental effects on cognitive function and therefore compromise patient wellbeing. On the other hand, some agents may serve to enhance cognitive function. In this review paper, we highlight the range of effects on cognition linked to a variety of newer and older AEDs, encompassing key alterations in both specific executive abilities and broader neuropsychological functions. Importantly, the data reviewed suggest that the effects exerted by an AED could vary depending on both patient characteristics and drug-related variables. However, there are considerable difficulties in evaluating the available evidence. Many studies have failed to investigate the influence of patient and treatment variables on cognitive functioning. Other difficulties include variation across studies in relation to design, treatment group and assessment tools, poor reporting of methodology and poor specification of the cognitive abilities assessed. Focused and rigorous experimental designs including a range of cognitive measures assessing more precisely defined abilities are needed to fill the gaps in our knowledge and follow up reported patterns in the literature. Longitudinal studies are needed to improve our understanding of the influence of factors such as age, tolerance and the stability of cognitive effects. Future trials comparing the effects of commonly prescribed agents across patient subgroups will offer critical insight into the role of patient characteristics in determining the cognitive impact of particular AEDs.

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“…Recurrent seizures and abnormal electrical activity may also cause MR [7,8] , such as epileptic encephalopathy. Furthermore, long-term therapy with antiepilepsy drugs (AEDs) can affect the patient's cognition and exacerbate MR [9] .…”

Section: Introductionmentioning

confidence: 99%

Anterior Corpus Callosotomy in Patients with Intractable Generalized Epilepsy and Mental Retardation

Liang¹,

Li²,

Jiang³

et al. 2010

Stereotact Funct Neurosurg

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Aims: To prospectively study outcomes of anterior corpus callosotomy (aCCT) in patients with refractory generalized epilepsy (RGE) and mental retardation (MR), and estimate the effect of preoperative Wechsler Full Scale Intelligence Quotient (FIQ) on surgical outcomes. Methods: Selected patients with RGE were divided into a moderate MR group (MoMR), mild MR group (MiMR) and no MR group (NMR), and all of them were treated with aCCT. Seizure outcomes were evaluated at the 1-year follow-up (1FU) and 2-year follow-up (2FU), and changes of quality of life (QOL) and IQ were tested at 2FU. Results: Seizure control did not differ by group or follow-up period. Most seizure reduction was achieved in atonic or tonic seizures with 76–80% reduction at 1FU and 81–87% at 2FU; myoclonic epilepsy was the least likely to respond. QOL changes differed among groups, and 53.2% of total patients showed postoperative QOL improvement: 75% in the MoMR group, 65% in the MiMR group and 21.1% in the NMR group. No significant group difference was seen in FIQ change, although average postoperative performance IQ (PIQ) improvement in patients with MR exceeded 4 points. Conclusion: aCCT can reduce seizures and is a safe surgical procedure. Low IQ does not affect seizure outcome and can be associated with a good surgical outcome in PIQ and QOL improvement.

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Efficacy and cognitive side effects of tiagabine and topiramate in patients with epilepsy

Cited by 139 publications

References 31 publications

Functional connectivity networks are disrupted in left temporal lobe epilepsy

Functional connectivity networks are disrupted in left temporal lobe epilepsy

The cognitive impact of antiepileptic drugs

Anterior Corpus Callosotomy in Patients with Intractable Generalized Epilepsy and Mental Retardation

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