Efficacy and Optimal Dose of Coenzyme Q10 Supplementation on Inflammation‐Related Biomarkers: A GRADE‐Assessed Systematic Review and Updated Meta‐Analysis of Randomized Controlled Trials

Abstract

Scope: Coenzyme Q10 (CoQ10) has become a popular nutritional supplement due to its wide range of beneficial biological effects. Previous meta-analyses show that the attenuation of CoQ10 on inflammatory biomarkers remains controversial. This meta-analysis aims to assess the efficacy and optimal dose of CoQ10 supplementation on inflammatory indicators in the general population. Methods and results: Databases are searched up to December 2022 resulting in 6713 articles, of which 31 are retrieved for full-text assessment and included 1517 subjects. Double-blind randomized controlled trials (RCTs) of CoQ10 supplementation are eligible if they contain C reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-𝜶 (TNF-𝜶). CoQ10 supplementation can significantly reduce the levels of circulating CRP (SMD: −0.40, 95% CI: [−0.67 to −0.13], p = 0.003), IL-6 (SMD: −0.67, 95% CI: [−1.01 to −0.33], p < 0.001), and TNF-𝜶 (SMD: −1.06, 95% CI: [−1.59 to −0.52], p < 0.001) and increase the concentration of circulating CoQ10. Conclusion: This meta-analysis provides evidence for CoQ10 supplementation to reduce the level of inflammatory mediators in the general population and proposes that daily supplementation of 300-400 mg CoQ10 show superior inhibition of inflammatory factors.

Effect of a multinutrient supplement as an adjunct to nonsurgical treatment of periodontitis: A randomized placebo‐controlled clinical trial

“…Although the effect of the consumption of a multinutrient supplement in addition to conservative periodontal therapy on clinical parameters of periodontitis seems to be moderate, a potential reduction in inflammatory markers such as IL-6, IL-12, IL-17, and TNF-α could have a beneficial effect on the healing process, as was shown in a recent meta-analysis on coenzyme Q-10 consumption and an RCT on Omega-3 polyunsaturated fatty acids as an adjunct to non-surgical treatment of periodontitis. 47,48 Therefore, in future studies, salivary biomarkers could be used to evaluate antiinflammatory effects of multinutrients on a biochemical level.…”

Prospects of Intravenous Coenzyme Q10 Administration in Emergency Ischemic Conditions

“…CoQ10's anti-inflammatory effects manifest at the onset of ischemia. These effects are attributed to CoQ10's membrane-stabilizing and antioxidant actions, as well as CoQ10' inhibition of inflammation-related cytokine gene expression and the elevation of anti-inflammatory biomarkers levels [33,66].…”

“…A meta-analysis encompassing 31 randomized clinical trials with 1517 subjects, evaluated the anti-inflammatory effects of CoQ10 regarding C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), and interleukin 6 (IL-6). It revealed a significant antiinflammatory effect of CoQ10 at a daily dose of 300-400 mg [33].…”

Prospects of Intravenous CoenzymeQ10 Administration in Emergency Ischemic Conditions

“…A meta-analysis conducted by Shanshan Hou (2023), encompassing 31 randomized clinical trials, evaluated the anti-inflammatory effects of CoQ10 regarding CRP, TNF-α, and IL-6. It revealed a significant anti-inflammatory effect of CoQ10 at a daily dose of 300-400 mg [31].…”