Efficacy and safety of basic fibroblast growth factor in the treatment of burns

Abstract

Background: To systematically evaluate the efficacy and safety of basic fibroblast growth factor (bFGF) in the treatment of burns and to provide evidence-based medical information for clinicians to choose the appropriate treatment measures for burns. Methods: Seven databases, including PubMed, the Cochrane Library, Embase, the Chinese Biomedical Literature Database, the Wanfang Database, the China National Knowledge Infrastructure Internet, and the Chongqing Chongqing Weipu Chinese Science and Technology Journal Full-text Database (VIP), were searched by computer. Randomized controlled trials on bFGF in the treatment of burns were collected, and the search was conducted by using a combination of subject terms (MeSH) and free words. The search time limit was from the establishment of each database until January 2019. Two researchers independently screened the literature and extracted the data. According to the evaluation criteria recommended in the Cochrane Handbook for Systematic Reviews of Interventions version 5.3.0, they conducted a rigorous bias risk assessment for the included studies, and Stata 12.0 software was used for meta-analysis. Results: System evaluation and meta-analysis were carried out strictly in accordance with the requirements of the Cochrane Handbook for Systematic Reviews of Interventions version 5.3.0 on meta-analysis and provided a high-quality evaluation of the efficacy and safety of bFGF in the treatment of burns. Conclusion: This study provided conclusions from evidence-based medicine and a scientific basis for the efficacy and safety of bFGF in the clinical treatment of burns. Ethics and dissemination: This study was not a clinical trial and therefore did not require ethical approval. The results of this study will be published in an SCI academic journal related to this study in the form of a public publication. PROSPERO registration number: CRD42019124778.

Effects of vitamin C combined with rbFGF on inflammatory factors and oxygen environment in patients with high‐voltage electrical burns

“…Ahn 16 believed that rbFGF can effectively shorten the treatment time of patients with deep second‐degree burns and has good safety. The research of Zhan 17 pointed out that rbFGF can effectively treat burn patients with good safety, which provides a scientific basis for the treatment of clinical burns. The results of our study showed that after treatment, the disappearance time of erythema, pain, swelling, blisters, and exudate symptoms, wound healing time, crusting time, and hospitalisation time in the research group were better than those in the control group, suggesting that vitamin C combined with rbFGF can effectively shorten the time to disappearance of clinical symptoms in patients with high‐voltage electrical burns, shortens the time of scabbing and hospitalisation.…”