Efficacy and Safety of Serenoa repens Extract Among Patients with Benign Prostatic Hyperplasia in China: A Multicenter, Randomized, Double-blind, Placebo-controlled Trial

Ye, Zhangqun; Huang, Jian; Zhou, Liqun; Chen, Shan; Wang, Zengjun; Ma, Lulin; Wang, Dongfang; Wang, Gongxian; Wang, Shusheng; Liang, Chaozhao; Qiu, Shaofu; Gu, Xiaoqing; Liu, Jianhe; Weng, Zhiliang; Wu, Changli; Wang, Qiang; Xie, Liping; Wu, Wei; Cheng, Yufeng; Hu, Jing-qian; Wang, Zhixian; Zeng, Xiaoyong

doi:10.1016/j.urology.2019.02.030

Cited by 29 publications

(83 citation statements)

References 27 publications

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“…Natural products, mainly of plant origin, are gaining interest all over the world. Some of them are already used as a substitute or complementary to unconventional forms of drugs due to the toxicity and side effects of synthetic drugs [ 24 , 25 , 26 , 27 , 28 , 29 ].…”

Section: Nutrition Value and Mineral Content Of P Padusmentioning

confidence: 99%

Phytopharmacological Possibilities of Bird Cherry Prunus padus L. and Prunus serotina L. Species and Their Bioactive Phytochemicals

2020

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Wild cherry is a plant observed in the form of trees or shrubs. This species comprises about twenty kinds of plants and the most popular are two, Prunus padus L. and Prunus serotina L., whose properties and content of phytochemical compounds are subject to studies. Wild cherry contains many active compounds, including tocopherols, vitamins, polyphenols and terpenes, which can have beneficial effects on health. On the other hand, wild cherry contains cyanogenic glycosides. Nevertheless, current research results indicate pro-health properties associated with both P. serotina and P. padus. The aim of this study was to collect and present the current state of knowledge about wild cherry and to review available in vitro and in vivo studies concerning its antioxidant, anti-inflammatory, antibacterial and antidiabetic activity. Moreover, the current work presents and characterizes phytochemical content in the leaves, bark and fruits of P. padus and P. serotina and compiles data that indicate their health-promoting and functional properties and possibilities of using them to improve health. We find that the anatomical parts of P. padus and P. serotina can be a valuable raw material used in the food, pharmaceutical and cosmetic industries as a source of bioactive compounds with multi-directional action.

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Section: Nutrition Value and Mineral Content Of P Padusmentioning

confidence: 99%

Phytopharmacological Possibilities of Bird Cherry Prunus padus L. and Prunus serotina L. Species and Their Bioactive Phytochemicals

2020

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“…Sinescu et al have reported the long-term efficacy of SP extract in improving the LUTS, urinary flow, erectile dysfunction and quality of life (QoL) [4]. In a recent double-blind, placebo-controlled study Ye et al reported the improvements in LUTS and male sexual function followed by treatment with SP extract [5]. SP extract demonstrated equivalent efficacy when compared to treatments with other alpha-blockers and 5-ARIs [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

A double blind, placebo-controlled randomized comparative study on the efficacy of phytosterol-enriched and conventional saw palmetto oil in mitigating benign prostate hyperplasia and androgen deficiency

Sudeep¹,

Thomas²,

Shyamprasad³

2020

BMC Urol

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Background: The present clinical trial was conducted to evaluate the efficacy and tolerability of a standardized saw palmetto oil containing 3% β-sitosterol in the treatment of benign prostate hyperplasia (BPH) and androgen deficiency. Methods: Subjects aged 40-65 years with symptomatic BPH were randomized to 12-week double-blind treatment with 500 mg doses of β-sitosterol enriched saw palmetto oil, conventional saw palmetto oil and placebo orally in the form of capsules (n = 33 in each group). BPH severity was determined using the International Prostate Symptom Score (IPSS), uroflowmetry, serum measurement of prostate specific antigen (PSA), testosterone and 5α-reductase. During the trial, the androgen deficiency was evaluated using Aging Male Symptoms (AMS) scale, the Androgen Deficiency in the Aging Male (ADAM) questionnaire, serum levels of free testosterone. Results: Subjects treated with β-sitosterol enriched saw palmetto oil showed significant decrease in IPSS, AMS and ADAM scores along with reduced postvoiding residual volume (p < 0.001), PSA (p < 0.01) and 5α-reductase from baseline to end of 12-week treatment as compared to placebo. There was also a significant increment in the maximum and average urine flow rate (p < 0.001), and serum free testosterone level of subjects treated with enriched saw palmetto oil as compared to placebo. Conclusion: This study demonstrates the efficacy of β-sitosterol enriched saw palmetto oil superior to conventional oil thus extending the scope of effective BPH and androgen deficiency treatment with improved quality of life through the intake of functional ingredients.

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“…The two-year study by Pytel, et al [33] reported an incidence of side effects of 5.8% for Permixon, whereas the three-year study by Schulman, et al [45], using tamsulosin reported side effects in 26% of patients. Ye, et al evaluated LSESr in 354 patients over six months and reported side effects in 1.18% of patients, which was almost identical to the 1.89% rate in the placebo arm [46]. In the placebo-controlled CAMUS trial, there were no significant differences in the incidence of adverse events between LSESr (ethanol extraction) and placebo [47].…”

Section: Lsesr Has a High Safety Profile In Contrast To Counterpart Prescription Drugsmentioning

confidence: 91%

<i>Serenoa repens</i> (Saw Palmetto) for Lower Urinary Tract Symptoms (LUTS): The Evidence for Efficacy and Safety of Lipidosterolic Extracts. Part II

Strum¹

2021

Preprint

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Part I of this 3-part series provided the groundwork for understanding the role of a standardized lipidosterolic extract of Serenoa repens (LSESr) in the treatment of LUTS. It documented that a treatment having a high therapeutic index (i.e., a ratio of benefit to adverse reactions) is a critical need in the demographic context of a rapidly growing elder population. Part I described the clinical symptomatology of LUTS and how it is quantified. A critique of the reports from four authoritative bodies: the European Scientific Cooperative on Phytotherapy (ESCOP), Cochrane 2012, the European Medicines Agency (EMA), and the AUA (American Urological Association) was presented. The foundation above then fine-tuned our search to require (a) consistent evaluability criteria, (b) the quantification of clinical findings, (c) the need to focus on studies employing a standardized LSESr product meeting the fatty acid profile set forth by the European Medicines Agency (EMA) and the US Pharmacopeia and (d) a global assessment of scientific investigations published in all languages and not limited to only English. Part II details the following “new” findings when LSESr vs. LUTS is examined with the above constraints.

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Efficacy and Safety of Serenoa repens Extract Among Patients with Benign Prostatic Hyperplasia in China: A Multicenter, Randomized, Double-blind, Placebo-controlled Trial

Cited by 29 publications

References 27 publications

Phytopharmacological Possibilities of Bird Cherry Prunus padus L. and Prunus serotina L. Species and Their Bioactive Phytochemicals

Phytopharmacological Possibilities of Bird Cherry Prunus padus L. and Prunus serotina L. Species and Their Bioactive Phytochemicals

A double blind, placebo-controlled randomized comparative study on the efficacy of phytosterol-enriched and conventional saw palmetto oil in mitigating benign prostate hyperplasia and androgen deficiency

<i>Serenoa repens</i> (Saw Palmetto) for Lower Urinary Tract Symptoms (LUTS): The Evidence for Efficacy and Safety of Lipidosterolic Extracts. Part II

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