Efficacy and safety of “Yahom” as a traditional Thai herbal therapy: A systematic review

Chootip, Krongkarn; Chaiyakunapruk, Nathorn; Soonthornchareonnon, Noppamas; Scholfield, C.N.; Fuangchan, Anjana

doi:10.1016/j.jep.2016.12.002

Cited by 11 publications

(3 citation statements)

References 20 publications

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“…Recent studies have focused intensively on the discovery of new antimicrobial compounds from a wide variety of plants ( Chootip et al., 2017 ) in relation to human disease-causing microbes. It has also been observed that there is an increased interest in the development of sustainable antifungal agents, such as plant-based essential oils and extracts, to combat plant diseases ( Costa et al., 2000 ; Rahman et al., 2010 ).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of phytoconstituents in marigold effluent for their antifungal activity against plant pathogens

Sanam,

Nagaraju,

P. S

et al. 2024

Front. Fungal Biol.

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The current study placed an intense emphasis on the excess discharge of agro-based industrial effluent and the use of plant extract antimicrobials to inhibit the growth of pathogens in crop plants. An effluent (treated and untreated) from the marigold flower processing industry has been identified for the presence of volatile and semi-volatile organic compounds, and a total of 18 in treated effluent and 23 in untreated effluent were found using gas chromatography–mass spectrometry. A total of 13 classes were identified, which include carboxylic acid, phenols, esters, alkanes, alkenes, alcohols, cyanide, heterocyclic, flavonoids, aldehydes, polycyclic aromatic, cycloalkanes, and cycloalkenes. A principal component analysis with varimax rotation was applied to discern the abundance of identified compounds under each class. An in vitro antifungal bioassay was conducted using effluents at three different concentrations against plant pathogens (Alternaria alter nata, Sclerotium rolfsii, Rhizoctonia solani, Pythium aphanidermata, Fusarium oxysporum, and Colletotrichum gloeosporioides). The study proved that treated and untreated effluents clearly inhibited the growth of fungal pathogens by 10 to 32% and 37 to 92%, respectively. The findings suggest that marigold flower effluent can be a promising resource for developing new plant protection methods that are effective against pathogenic fungi.

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Section: Introductionmentioning

confidence: 99%

Evaluation of phytoconstituents in marigold effluent for their antifungal activity against plant pathogens

Sanam,

Nagaraju,

P. S

et al. 2024

Front. Fungal Biol.

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“…Several polyherbal preparations have been prescribed in Thai traditional medicine. A few formulas, such as Benja Amarit [ 26 ], Ya-hom [ 27 ], Jatu-Phala-Tiga [ 28 ], have been scientifically proven to exhibit biological activities related to their traditional use. In the present study, the traditional herbal medicine described in the Worayokasan scripture named Nawametho decoction was chosen because it has been used as an alternative treatment for borderline hyperlipidemic patients at Ban Ta Khun Hospital (Surat Thani, Thailand).…”

Section: Introductionmentioning

confidence: 99%

Clinical Evaluation of a Novel Tablet Formulation of Traditional Thai Polyherbal Medicine Named Nawametho in Comparison with Its Decoction in the Treatment of Hyperlipidemia

Jaisamut

Tohlang

Wanna

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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In the traditional medical system in Thailand, medicinal plants and polyherbal medicines have been prescribed as lipid-lowering agents, including Nawametho decoction. This polyherbal formulation is described in the Worayokasan scripture. It consists of nine medicinal plants (Aegle marmelos (L.), Carthamus tinctorius L., Hibiscus sabdariffa Linn., Phyllanthus emblica L., Piper longum L., Piper nigrum L., Terminalia bellirica (Gaertn.) Roxb., Terminalia chebula Retz., and Zingiber officinale Roscoe). Apart from its utilization in Thai traditional medicine, there is a lack of evidence supporting its use. This research work thereby aims to formulate and evaluate the tablet containing Nawametho decoction. The feasibility of Nawametho decoction and NawaTab for patients with borderline hyperlipidemia was additionally examined using a prospective, open-label, randomized, parallel-group design. The dry granulation technique was employed to formulate the polyherbal tablets. The tablets were developed using the spray-dried Nawametho decoction as the active ingredient in addition to other excipients. The chosen formulation, the FB (NawaTab), consisted of 385 milligrams of the extract, 12% w/w of a diluent (lactose), 8% w/w of a lubricant (magnesium stearate), 5% w/w of a disintegrant (microcrystalline cellulose), and 5% w/w of an anti-adherent (talcum). Their hardness, friability, and disintegration time were 4.4 ± 0.32 kg, 0.05 ± 0.02%, and 4.60 ± 0.05 min, respectively. Accelerated stability study results revealed that NawaTab was stable for six months at 40°C/75% RH and 25°C/60% RH. Even though taking NawaTabs (500 mg twice daily) for eight consecutive weeks was unable to improve the lipid profile of the patients, the administration of Nawametho decoction (30 mL twice daily) was associated with a significant decrease in serum triglycerides of the patients. The results show that the dry granulation technique is suitable for the formulation of NawaTab based on the tablet evaluation. Furthermore, the triglyceride-lowering effect of Nawametho decoction was reported for the first time.

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“…Their fragrant resinous wood has long been used in Ayurvedic and traditional medicine for treatment of various illness such as joint pain, inflammatory-related disorder, diarrhea, and also used as a sedative, stimulant and cardio-protectant 1 . In Thailand, agarwood is the main ingredient in the herbal remedy called “Yahom” used for treatment of fainting and abdominal discomfort 2 . Several reports describe biological activities in the resin derived from heartwood and in the leaves of Aquilaria spp 1 .…”

Section: Introductionmentioning

confidence: 99%

Extract of Aquilaria crassna leaves and mangiferin are vasodilators while showing no cytotoxicity

Wisutthathum

Kamkaew

Inchan

et al. 2019

Journal of Traditional and Complementary Medicine

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The leaves of Aquilaria spp. promote “physiological balance”, and are “cardiotonic and provide blood nourishment”. In Asia, these leaves are increasingly consumed as tea and claimed to provide benefits to cardiovascular function, albeit without any scientific proof. Therefore, this study sought to evaluate the action of Aquilaria crassna leaf aqueous extract (AE) on vascular function and vascular smooth muscle cytotoxicity. AE and a main constituent, mangiferin were investigated for their vasorelaxation of rat mesenteric arteries and aortae in vitro . Acute cytotoxicity of AE (0.1–1000 μg/ml) and mangiferin (0.1–100 μM) on rat enzymatically isolated vascular smooth muscle cells was assayed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide. AE dilated rat mesenteric arteries (EC 50 ∼107 μg/ml, E max ∼95%) more than aorta (EC 50 ∼265 μg/ml, E max ∼76%, p < 0.05). AE-induced vasodilation in mesenteric artery was reduced by endothelial removal (EC 50 ∼202 μg/ml, p < 0.05), incubation with endothelial nitric oxide synthase (eNOS) (100 μM, L -NAME) (EC 50 ∼309 μg/ml, p < 0.05), and partly reduced by L-type Ca 2+ channel blockade at higher concentrations. Likewise, mangiferin (1–100 μM) dilated the mesenteric artery more potently than the aorta. However, its maximum relaxation was less than with AE (41% in the mesenteric artery and <10% in the aorta). Isolated vascular smooth muscle cells incubated in AE or mangiferin for 1 h showed no cytotoxicity. Thus, AE is a vasorelaxant while being free of acute cytotoxicity towards vascular smooth muscle, thus potentially ameliorating human vascular dysfunction.

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Efficacy and safety of “Yahom” as a traditional Thai herbal therapy: A systematic review

Cited by 11 publications

References 20 publications

Evaluation of phytoconstituents in marigold effluent for their antifungal activity against plant pathogens

Evaluation of phytoconstituents in marigold effluent for their antifungal activity against plant pathogens

Clinical Evaluation of a Novel Tablet Formulation of Traditional Thai Polyherbal Medicine Named Nawametho in Comparison with Its Decoction in the Treatment of Hyperlipidemia

Extract of Aquilaria crassna leaves and mangiferin are vasodilators while showing no cytotoxicity

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