Efficacy of a calcium‐phosphate/fluoride varnish and ionomeric sealant on cervical dentin hypersensitivity: A randomized, double‐blind, placebo‐controlled clinical study

Abstract

Background Dentin hypersensitivity (DH) is a common problem in the population that can have a significant impact on the quality of life of those who suffer from the condition. Objectives Compare the efficacy of two treatments for DH: Ca/PO4−/F− varnish (Clinpro White Varnish) and ionomeric sealant (IS) (Clinpro XT Varnish) with a placebo. Methods Participants (121) with at least one tooth with visual analogue scale (VAS) score of 4 and above were randomly and blindly allocated to the groups. Treatments were performed by a trained researcher. DH was evaluated by another blind researcher after the treatment and after 1 week, 4 weeks, 3 months and 6 months. After 4 weeks, placebo received the DH treatment with IS; thus, the participants were not assessed after 3 and 6 months. Primary outcome was DH reduction after 4 weeks. Differences in VAS scores in the other time intervals and entire values of VAS were considered secondary outcomes. Comparisons were made among the groups (α = 0.05). Results IS showed the highest VAS value difference between baseline and 4 weeks (mean ± SD: 3.7 ± 2.2), differing significantly from placebo (2.3 ± 1.7) and Ca/PO4/F− varnish (2.6 ± 2.0). Ca/PO4−/F− varnish did not differ from placebo. In all time intervals, VAS values of all groups were significantly lower than the baseline value, without differences among groups. For the long‐term differences in VAS values (3 and 6 months), the IS exhibited significantly higher values than Ca/PO4−/F− varnish. Conclusions The IS was the most efficacious product for reducing DH, whereas Ca/PO4−/F− varnish did not differ from placebo. Registered in ClinicalTrials.gov (NCT04591444).

The Effectiveness of Calcium Phosphates in the Treatment of Dentinal Hypersensitivity: A Systematic Review

“…It is worth noting that the hypersensitivity reduction efficacy of nano-hydroxyapatite was increased du to the adjunction of sodium [ 58 ] or ionometric sealant [ 59 ] or when combined with laser treatment [ 60 ].…”

Evaluation of Propolis Hydrogel for the Treatment of Dentinal Sensitivity: A Clinical Study

“…The current study aimed to evaluate and compare the efficacy of a 10% propolis hydrogel with 2% sodium fluoride (NaF) and 1.23% acidulated phosphate fluoride (APF) reinforced with iontophoresis for the treatment of DH. According to the author’s knowledge, very little evidence exists on the use of propolis in combination with iontophoresis for DH [ 35 , 36 , 37 , 38 , 39 , 40 , 41 ]. Thus, the hypothesis formulated was that a 10% propolis hydrogel reinforced with iontophoresis would provide better relief for DH when compared to iontophoresis-enhanced 2% NaF and 1.23% APF.…”