Efficacy of a single application of a 12.5% pyriprole topical solution against laboratory infestations with ticks (Ixodes ricinus, Dermacentor reticulatus, and Rhipicephalus sanguineus) on dogs

Schuele, G.; Barnett, S.; Bapst, B.; Cavaliero, T.; Luempert, Louis G.; Strehlau, G.; Young, D. R.; Moran, C.; Junquera, P.

doi:10.1016/j.vetpar.2008.03.007

Cited by 8 publications

(4 citation statements)

References 6 publications

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“…Therefore the repellent and acaricidal effect of both drugs was demonstrated only by the temporary influence on tick infestation but not by any influence on infection incidence during the year. Efficacy studies on acaricidal drugs under laboratory conditions result in a maximum positive measureable effect on tick killing and prevention of pathogen transmission [12,14,30], although Estrada-Pena and Venzal Bianchi [31] also described an insufficient prevention of the transmission of Rickettsia conorii after application of fipronil + S-methoprene and permethrin; only amitraz was able to reduce transmission effectively. Especially the permethrin spot on, used in this trial, has been demonstrated to have a proven high efficacy in the protection against TBD transmission when administered correctly either in a regular treatment regime [13] or within the claimed efficacy period [12].…”

Section: Discussionmentioning

confidence: 99%

Effect of owner-controlled acaricidal treatment on tick infestation and immune response to tick-borne pathogens in naturally infested dogs from Eastern Austria

et al. 2013

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BackgroundTick-borne infections resulting from regular tick infestation in dogs are a common veterinary health problem all over the world. The application of repellent and acaricidal agents to prevent transmission of pathogens is a major protection strategy and has been proven to be highly effective in several trials under laboratory and natural conditions in dogs. Despite such promising results, many dog owners still report tick infestation in their dogs although acaricidal agents are used. Information about the current infection status and changes of the infection status regarding tick-borne diseases (TBD) in dogs treated by the owner’s controlled acaricide application is lacking.MethodsIn this study 30 dogs were each treated with permethrin, fipronil + S-methoprene, or served as untreated controls. Application of the acaricide was performed by the owner who decided when and how often to use the spot on preparation. Over a period of 11 months, dogs were clinically examined and sampled for antibody responses against Babesia canis, Anaplasma phagocytophilum, Borrelia burgdorferi s. l., and TBE virus before the study started, 6 months later and at the end of the investigation period.ResultsThe permethrin acaricide was applied on average 3.40 times within the examination period, whereas the fipronil + S-methoprene medication was applied 3.03 times. Approximately 2/3 of all dogs, independent of the group, had a positive immune response to one or more pathogens. Three dogs developed clinical symptoms of canine babesiosis, all other dogs remained healthy. Individual number of ticks per dog or number of infections per dog did not correlate with the application rate, and the number of ticks per dog did not influence the number of infections per dog. As owners did not apply the acaricides regularly no influence on the number of infections could be documented although the number of ticks was clearly reduced by the application of the spot-on drugs.ConclusionsClinical disease in dogs exposed to tick-borne pathogens is rare, although a humoral immune response reflecting infection is common. More educational training for dog owners is necessary to make the application of acaricides effective regarding the prevention of tick-borne diseases.

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Section: Discussionmentioning

confidence: 99%

Effect of owner-controlled acaricidal treatment on tick infestation and immune response to tick-borne pathogens in naturally infested dogs from Eastern Austria

et al. 2013

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“…More recently, pyriprole from the same chemical group had been launched and is available as a spot-on (Schuele et al 2008). Finally, as fipronil’s patent has recently expired, new fipronil-based products are now present on the market.…”

Section: Introductionmentioning

confidence: 99%

Comparative efficacy of two fipronil spot-on formulations against experimental tick infestations (Ixodes ricinus) in dogs

Bonneau

Gupta²,

Cadiergues

2010

Parasitol Res

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A parallel-group-design, randomized, unicentre and blinded controlled study was undertaken to assess the efficacy of a new fipronil-based spot-on formulation applied once to dogs against experimental Ixodes ricinus infestations. Six dogs served as negative controls (group 1), six dogs served as positive controls (group 2) receiving the original fipronil spot-on (Frontline® spot-on Dog, Merial) at a dosage of 0.67 mL for a dog weighing from 2 to 10 kg and 1.34 mL for a dog weighing from 10.1 to 20 kg and six dogs were treated with a 10% w/v fipronil-based spot-on solution (Effipro® Spot-on, Virbac SA) at an identical dosage (group 3, 0.67 mL for a dog weighing from 2 to 10 kg and 1.34 mL for a dog weighing from 10.1 to 20 kg). Each dog was sedated and subsequently infested with 50 unfed adult I. ricinus on days −7, −2, 7, 14, 21, 28 and 35. Forty-eight hours after the treatment and 48 h after each challenge (days −5, 2, 9, 16, 23, 30 and 37), the population of the remaining ticks was assessed for each animal. Geometric mean tick counts obtained were reduced by 99% and 94% on day 2 in groups 2 and 3, respectively, compared to the negative control group. Dogs were protected from re-infestations with an efficacy of >90% for 3 weeks in group 2 and for 5 weeks in group 3. Both 10% w/v fipronil-based spot-on solutions, despite different vehicles, were equally able to eradicate tick infestation, to prevent new infestations and were equally well tolerated.

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“…Amide bond formation involving acid-amine coupling is an important synthetic tool for the manufacture of pharmaceuticals and fine chemicals (Schuele et al, 2008). The use of a variety of acid-amine coupling agents, most commonly carbodiimides and onium salts such as phosphonium as well as ammonium salts, for amide bond synthesis has been reviewed (Al-Warhi et al 2012;Urich et al, 2014).…”

Section: Chemical Contextmentioning

confidence: 99%

N-(6-Methoxypyridin-2-yl)-1-(pyridin-2-ylmethyl)-1H-pyrazole-3-carboxamide: crystal structure and Hirshfeld surface analysis

Ramani

Shah

Jotani³

et al. 2018

Acta Cryst E

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Efficacy of a single application of a 12.5% pyriprole topical solution against laboratory infestations with ticks (Ixodes ricinus, Dermacentor reticulatus, and Rhipicephalus sanguineus) on dogs

Cited by 8 publications

References 6 publications

Effect of owner-controlled acaricidal treatment on tick infestation and immune response to tick-borne pathogens in naturally infested dogs from Eastern Austria

Effect of owner-controlled acaricidal treatment on tick infestation and immune response to tick-borne pathogens in naturally infested dogs from Eastern Austria

Comparative efficacy of two fipronil spot-on formulations against experimental tick infestations (Ixodes ricinus) in dogs

N-(6-Methoxypyridin-2-yl)-1-(pyridin-2-ylmethyl)-1H-pyrazole-3-carboxamide: crystal structure and Hirshfeld surface analysis

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