Efficacy of ginseng adventitious root extract on hyperglycemia in streptozotocin-induced diabetic rats

Murthy, Hosakatte Niranjana; Dandin, Vijayalaxmi S.; Lee, Eun Jung; Paek, Kee-Yoeup

doi:10.1016/j.jep.2014.03.062

Cited by 32 publications

(18 citation statements)

References 17 publications

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“…In addition, EARMG remarkably decreased the glucose level. It was previously reported that there was a significant decrease in TG level in diabetic rats fed with the extracts of tissue-cultured adventitious roots of mountain ginseng [42]. Such an effect was also achieved in a human study [43], wherein ginsenosides stimulated lipid metabolism in diabetic individuals.…”

Section: Discussionmentioning

confidence: 74%

“…In addition, ginsenosides such as Rb 3 , Rg 2 , Rg 3 , Rh 1 , and Rh 2 which were lacking in the extracts of field-cultivated Korean ginseng were abundant in ARMG [42]. Notably, it is well known that higher amounts of original ginsenosides and other novel ginsenosides are accumulated by treatment with methyl jasmonate during the tissue culture which is not contained process in Korean ginseng field cultivation [12].…”

Section: Discussionmentioning

confidence: 99%

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Blood flow-improving activity of methyl jasmonate-treated adventitious roots of mountain ginseng

et al. 2017

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Ginsenosides from Panax ginseng are well known for their diverse pharmacological effects including antithrombotic activity. Since adventitious roots of mountain ginseng (ARMG) also contain various ginsenosides, blood flow-improving effects of the dried powder and extract of ARMG were investigated. Rats were orally administered with dried powder (PARMG) or ethanol extract (EARMG) of ARMG (125, 250 or 500 mg/kg) or aspirin (30 mg/kg, a reference control) for 3 weeks. Forty min after the final administration, carotid arterial thrombosis was induced by applying a 70% FeCl3-soaked filter paper outside the arterial wall for 5 min, and the blood flow was monitored with a laser Doppler probe. Both PARMG and EARMG delayed the FeCl3-induced arterial occlusion in a dose-dependent manner, doubling the occlusion time at high doses. In mechanism studies, a high concentration of EARMG inhibited platelet aggregation induced by collagen in vitro. In addition, EARMG improved the blood lipid profiles, decreasing triglyceride and cholesterol levels. Although additional action mechanisms remain to be clarified, it is suggested that ARMG containing high amount of ginsenosides such as Rg3 improves blood flow not only by inhibiting oxidative thrombosis, but also by modifying blood lipid profiles.

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Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Blood flow-improving activity of methyl jasmonate-treated adventitious roots of mountain ginseng

et al. 2017

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“…Moreover, all symptoms of diabetic nephropathy were improved by GS-E3D treatment via suppressing renal accumulation of AGEs and oxidative stress [47]. Tissue culture raised mountain ginseng adventitious root (TCMGARs) extracts at dosage levels of 250, and 500 mg/kg significantly reduced the blood glucose, total cholesterol, and triglyceride content in STZ-induced diabetic rats [38]. In an LDL -/mouse model, Rg3-enriched red ginseng extract (44.91 mg/g, 66.6% occupy for total ginsenosides) significantly decreased the levels of glucose, triglyceride, low-density lipoprotein, alanine aminotransferase and aspartate aminotransferase compared to the control [48].…”

Section: Potential Mechanisms Of the Anti-diabetic Effect Of Ginsengmentioning

confidence: 99%

Review of Ginseng Anti-Diabetic Studies

2019

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Ginseng is one of the most valuable and commonly used Chinese medicines not only in ancient China but also worldwide. Ginsenosides, also known as saponins or triterpenoids, are thought to be responsible for the beneficial effects of ginseng. In this review, we summarize recent publications on anti-diabetic studies of ginseng extracts and ginsenosides in cells, animals, and humans. It seems that the anti-diabetic effect of ginseng is positive for type 2 diabetic patients but has no significant impact on prediabetes or healthy adults. Regulation of insulin secretion, glucose uptake, anti-oxidative stress, and anti-inflammatory pathways may be the mechanisms involved with ginseng’s anti-diabetic effects. Taken together, this summary provides evidence for the anti-diabetes effects of ginseng extracts and ginsenosides as well as the underlying mechanisms of their impact on diabetes.

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“…Group D (Ginseng-treated group): alloxandiabetic rats and received 250 mg/kg B.Wt. ginseng alcohol-based extract (Nature's way company, USA) orallyfor 30 days according to Murtahy et al (2014).…”

Section: 2experimental Design and Treatmentmentioning

confidence: 99%

The Effect of Metformin and Ginseng on Alloxan-Induced Diabetic Rats: Hematological, Biochemical and Histopathological Studies

El-Karim¹,

Oda²,

Tohamy³

et al. 2017

AJVS

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Efficacy of ginseng adventitious root extract on hyperglycemia in streptozotocin-induced diabetic rats

Cited by 32 publications

References 17 publications

Blood flow-improving activity of methyl jasmonate-treated adventitious roots of mountain ginseng

Blood flow-improving activity of methyl jasmonate-treated adventitious roots of mountain ginseng

Review of Ginseng Anti-Diabetic Studies

The Effect of Metformin and Ginseng on Alloxan-Induced Diabetic Rats: Hematological, Biochemical and Histopathological Studies

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