Efficacy of Natural Deep Eutectic Solvents for Extraction of Hydrophilic and Lipophilic Compounds from Fucus vesiculosus

Obluchinskaya, E. D.; Pozharitskaya, Olga N.; Zakharova, Lyubov V; Daurtseva, A. V.; Flisyuk, E. V.; Shikov, Alexander N.

doi:10.3390/molecules26144198

Cited by 87 publications

(62 citation statements)

References 80 publications

(124 reference statements)

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“…The formulation of dosage forms plays a crucial role in the delivery, bioavailability, and stability of marine-derived compounds [17][18][19][20][21]. The topical application of drugs has several advantages compared to other routes of administration.…”

Section: Introductionmentioning

confidence: 99%

Formulation, Optimization and In Vivo Evaluation of Fucoidan-Based Cream with Anti-Inflammatory Properties

et al. 2021

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Fucoidan is a polysaccharide found in brown alga with glorious potential for pharmacological activities, among which its anti-inflammatory properties have gained meaningful attention. Due to several advantages of formulations for topical application, this study aimed to develop and optimize a fucoidan-based cream formulation and to investigate its anti-inflammatory potential after topical application in vivo. Fucoidan from Fucus vesiculosus L. was used. The cream base consisting of olive oil and Kolliphor RH40 was optimized followed by in vitro agar diffusion and drug release studies. The fucoidan-based cream with 13% Kolliphor P 407, 1% Transcutol P, and 5% PEG400 showed good spreadability, washability, and colloidal stability, and it did not irritate the skin. The kinetics of fucoidan release from the optimized cream exhibited the best fit to the Korsmeyer–Peppas and Higuchi models with R2 > 0.99. Fucoidan release was controlled by drug diffusion and anomalous transport provided by the optimized cream base. The formulation was stable and provided high fucoidan release after storage for 1 year. Topical application of the fucoidan-based cream dose-dependently inhibited carrageenan-induced edema and ameliorated mechanical allodynia in rats. The efficacy of the fucoidan-based cream at a high dose was comparable with the efficacy of diclofenac gel. The fucoidan-based cream could be considered a promising anti-inflammatory formulation.

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Section: Introductionmentioning

confidence: 99%

Formulation, Optimization and In Vivo Evaluation of Fucoidan-Based Cream with Anti-Inflammatory Properties

et al. 2021

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“…DESs represent a new generation of solvents that are emerging as the green solvents of the 21st century, mostly based on low-transition-temperature mixtures of cheap and easily available components. The possible combination of the starting materials to prepare the eutectic solvents is virtually countless; therefore, they are enjoying great success and interest as solvents for extracting bioactive compounds [64][65][66].…”

Section: Ultrasound-assisted Extractionmentioning

confidence: 99%

Valorization of Tomato Waste as a Source of Carotenoids

et al. 2021

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Fast-accumulating scientific evidence from many studies has revealed that fruits and vegetables are the main source of bioactive compounds; in most cases, wastes and byproducts generated by the food processing industry present similar or a higher content of antioxidant compounds. In recent years, the ever-growing amount of agricultural and food wastes has raised serious concerns from an environmental point of view. Therefore, there is an increasing interest in finding new ways for their processing toward safely upgrading these wastes for recovering high-value-added products with a sustainable approach. Among food waste, the abundance of bioactive compounds in byproducts derived from tomato suggests possibility of utilizing them as a low-cost source of antioxidants as functional ingredients. This contribution gives an overview of latest studies on the extraction methods of carotenoids from tomato waste, along with an evaluation of their antioxidant activity, as well as their industrial applications.

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“…NADES have several advantages over conventional extraction and ILs, including lower cost, biodegradability, and reduced toxicity [3,4,7,8]. NADES have been applied for the extraction of several bioactive natural products from marine and terrestrial sources, with high potential future use in commercial purposes, including hydrophilic and lipophilic compounds from Fucus vesiculosus [13], phlorotannins from brown algae [14], anthocyanins from blueberry peels [15] and gray berry [16], anthocyanins and phenolics from grape (Vitis vinifera) [7,9,17], flavonoids from Japanese pagoda tree (Sophora japonica), onion (Allium cepa), broccoli (Brassica oleracea var. italica), cranberry (Vaccinium sp.…”

Section: Introductionmentioning

confidence: 99%

Greener Is Better: First Approach for the Use of Natural Deep Eutectic Solvents (NADES) to Extract Antioxidants from the Medicinal Halophyte Polygonum maritimum L.

et al. 2021

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In this study, natural deep eutectic solvents (NADES) formed by choline chloride (ChCl), sucrose, fructose, glucose, and xylose, were used to extract antioxidants from the halophyte Polygonum maritimum L. (sea knotgrass) and compared with conventional solvents (ethanol and acetone). NADES and conventional extracts were made by an ultrasound-assisted procedure and evaluated for in vitro antioxidant properties by the radical scavenging activity (RSA) on the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical, oxygen radical absorbance capacity (ORAC), and copper chelating activity (CCA). Samples were profiled by liquid chromatography (LC)-electrospray ionization (ESI)-QTOF-MS analysis. ChCl:fructose was more efficient in the DPPH assay, than the acetone extract. ChCl:sucrose and ChCl:fructose extracts had the highest ORAC when compared with the acetone extract. NADES extracts had higher CCA, than the acetone extract. The phenolic composition of the NADES extracts was less complex than the conventional extracts, but the proportions of major antioxidants, such as flavonols and flavan-3-ols, were similar in all the solvents. Myricitrin was the major flavonoid in all of the samples, while gallic acid was the main phenolic acid in the conventional extracts and present in a greater amount in ChCl:fructose. Results suggest that NADES containing ChCl and sucrose/fructose can replace conventional solvents, especially acetone, in the extraction of antioxidants from sea knotgrass.

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Efficacy of Natural Deep Eutectic Solvents for Extraction of Hydrophilic and Lipophilic Compounds from Fucus vesiculosus

Cited by 87 publications

References 80 publications

Formulation, Optimization and In Vivo Evaluation of Fucoidan-Based Cream with Anti-Inflammatory Properties

Formulation, Optimization and In Vivo Evaluation of Fucoidan-Based Cream with Anti-Inflammatory Properties

Valorization of Tomato Waste as a Source of Carotenoids

Greener Is Better: First Approach for the Use of Natural Deep Eutectic Solvents (NADES) to Extract Antioxidants from the Medicinal Halophyte Polygonum maritimum L.

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