Efficacy of Optical Internal Urethrotomy and Intralesional Injection of Vatsala-Santosh PGI Tri-Inject (Triamcinolone, Mitomycin C, and Hyaluronidase) in the Treatment of Anterior Urethral Stricture

Kumar, Santosh; Garg, Nitin; Singh, Shrawan Kumar; Mandal, Arup Kumar

doi:10.1155/2014/192710

Cited by 27 publications

(22 citation statements)

References 15 publications

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“…Almost 92% of patients in the control group experienced recurrence of urethral stricture by 6 months, whereas a delay in recurrence was observed in 54% of patients in the mitomycin C group. Our observation agrees with the literature [ 20 22 23 25 ]. Significant improvement in uroflowmetry was observed in patients without recurrence in both groups.…”

Section: Discussionsupporting

confidence: 94%

“…Currently, a combination of antifibroblast agents containing mitomycin is being used with successful outcomes. Kumar et al [ 23 ] recorded the recurrence of urethral stricture in only 20% of cases after intralesional injections. Another study by Chung [ 24 ] also showed positive results of recurrence in only 10% with intralesional injections.…”

Section: Discussionmentioning

confidence: 99%

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Efficacy of mitomycin C in reducing recurrence of anterior urethral stricture after internal optical urethrotomy

et al. 2015

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PurposeTo determine the efficacy of mitomycin C in reducing the recurrence of anterior urethral stricture after internal optical urethrotomy (IOU).Materials and MethodsThis was a randomized controlled trial conducted in the Department of Urology at the Institute of Kidney Diseases Peshawar from March 2011 to December 2013. A total of 151 patients who completed the study were divided into two groups by the lottery method. Group A (cases) comprised 78 patients in whom mitomycin C 0.1% was injected submucosally in the stricture after conventional IOU. Group B (controls) comprised 73 patients in whom IOU only was performed. Self-clean intermittent catheterization was not offered in either group. All patients were regularly followed up for 18 months. Recurrence was diagnosed by use of retrograde urethrogram in all patients and flexible urethroscopy in selected cases. Data were collected on a structured pro forma sheet and were analyzed by SPSS.ResultsThe mean age of the patients in group A was 37.31±10.1 years and that in group B was 40.1±11.4 years. Recurrence of urethral stricture was recorded in 11 patients (14.1%) in group A and in 27 patients (36.9%) in group B (p=0.002). The mitomycin group also showed a delay in recurrence compared with the control group (p=0.002).ConclusionsRecurrence of urethral stricture is high after optical urethrotomy. Mitomycin C was found to be highly effective in preventing the recurrence of urethral stricture after IOU.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Efficacy of mitomycin C in reducing recurrence of anterior urethral stricture after internal optical urethrotomy

et al. 2015

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“…This trend continues despite the moderate success rate reported in the selected patients. To reduce the stricture recurrence rate, several investigators evaluated different intralesional adjuvant injections with variable success [ 18 – 23 ]. We set out to report the results of VIU of our patients, including a wider inclusion base and strict criteria of success in a long follow-up period.…”

Section: Resultsmentioning

confidence: 99%

Visual Internal Urethrotomy for Adult Male Urethral Stricture Has Poor Long-Term Results

Taweel

Seyam

2015

Advances in Urology

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Objective. To determine the long-term stricture-free rate after visual internal urethrotomy following initial and follow-up urethrotomies. Methods. The records of all male patients who underwent direct visual internal urethrotomy for urethral stricture disease in our hospital between July 2004 and May 2012 were reviewed. The Kaplan-Meier method was used to analyze stricture-free probability after the first, second, third, fourth, and fifth urethrotomies. Results. A total of 301 patients were included. The overall stricture-free rate at the 36-month follow-up was 8.3% with a median time to recurrence of 10 months (95% CI of 9.5 to 10.5, range: 2–36). The stricture-free rate after one urethrotomy was 12.1% with a median time to recurrence of eight months (95% CI of 7.1–8.9). After the second urethrotomy, the stricture-free rate was 7.9% with a median time to recurrence of 10 months (95% CI of 9.3 to 10.6). After the third to fifth procedures, the stricture-free rate was 0%. There was no significant difference in the stricture-free rate between single and multiple procedures. Conclusion. The long-term stricture-free rate of visual internal urethrotomy is modest even after a single procedure.

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“…[8,9] There are many investigations about use of drugs such as steroids, Mitomycin C, Hyaluronidase to avoid this scar or keloid formation. [10,11] We aimed to investigate the combination of steroid injection with IU in order to avoid the recurrence of strictures and cure the patient with minimally invasive treatment.…”

Section: Discussionmentioning

confidence: 99%

A Comparative Study of Optical Internal Urethrotomy Alone With Optical Internal Urethrotomy Plus Steroid for Anterior Urethral Stricture Disease

Govindaraju¹,

Ettappan²

2018

jemds

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BACKGROUND Urethral stricture is a relatively common urological disorder, which every urologist encounters in his regular urological practice. They pose a significant problem from both clinical and economic point of view. The aetiology of stricture of urethra has changed over time. Trauma has taken over infection as the commonest cause. The management of stricture also has evolved over the times. Despite the availability of various options for the treatment of stricture urethra, internal urethrotomy has remained a popular option among the urologists in view of its simplicity, safety and shorter learning curve. Aims and Objectives-To compare the outcome of optical internal urethrotomy between OIU alone and OIU with steroid injection at the site of stricture by means of recurrence rate and time duration for recurrence and symptom improvement in stricture patients. MATERIALS AND METHODS This is a prospective, randomised, controlled study by which comparing the outcome of optical internal urethrotomy alone with urethrotomy with steroid injection in the management of stricture disease in males is done. The study done during the period of

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Efficacy of Optical Internal Urethrotomy and Intralesional Injection of Vatsala-Santosh PGI Tri-Inject (Triamcinolone, Mitomycin C, and Hyaluronidase) in the Treatment of Anterior Urethral Stricture

Cited by 27 publications

References 15 publications

Efficacy of mitomycin C in reducing recurrence of anterior urethral stricture after internal optical urethrotomy

Efficacy of mitomycin C in reducing recurrence of anterior urethral stricture after internal optical urethrotomy

Visual Internal Urethrotomy for Adult Male Urethral Stricture Has Poor Long-Term Results

A Comparative Study of Optical Internal Urethrotomy Alone With Optical Internal Urethrotomy Plus Steroid for Anterior Urethral Stricture Disease

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