Efficacy of Propolis on the Denture Stomatitis Treatment in Older Adults: A Multicentric Randomized Trial

Pina, Gisela de Martins Souza; Lia, Erica Negrini; Berretta, Andresa Aparecida; Nascimento, Andresa Piacezzi; Torres, Elina Cassia; Buszinski, Andrei Felipe Moreira; Campos, Tatiana Amabile de; Coelho, Eduardo Barbosa; Martins, Vívian T.

doi:10.1155/2017/8971746

Cited by 30 publications

(41 citation statements)

References 57 publications

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“…In addition to the abovementioned T2DM, there was an improvement in the cognitive pattern in patients with Alzheimer's disease, associated with a reduction in inflammatory markers [ 4 ]. Clinical trials have shown the efficacy of propolis in the treatment of oral diseases associated with herpesvirus type I [ 34 ] and others, such as prosthetic stomatitis [ 35 ], recurrent cold sore [ 36 ], and periodontal disease, and the reduction of oxidative stress was shown in this last study [ 37 ]. Regarding EPP-AF®, a clinical trial with chronic renal patients with proteinuria showed a reduction in monocyte chemoattractant protein-1 (MCP-1), which is a marker of inflammation and proteinuria intensity [ 38 ].…”

Section: Discussionmentioning

confidence: 82%

Antioxidant Effect of Standardized Extract of Propolis (EPP‐AF®) in Healthy Volunteers: A “Before and After” Clinical Study

Diniz

Lorencini

Berretta

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Background. Propolis is rich in polyphenols, especially flavonoids and phenolic acids, and has significant antioxidant activity, shown mainly in “in vitro” studies. Objective. The aim of this study was to evaluate the antioxidant efficacy and safety of a standardized propolis extract in healthy volunteers. Design. A two-phase sequential, open-label, nonrandomized, before and after clinical trial. Methods. Healthy participants received two EPP-AF® doses (375 and 750 mg/d, P.O, tid) during 7 ± 2 days, starting with the lower doses. Immediately before starting EPP-AF® administration and at the end of each 7-day dosing schedule, blood and urine samples were collected for quantification of 8-OHDG (8-hydroxydeoxyguanosine) and 8-ISO (8-isoprostanes) in urine and GSH (reduced glutathione), GSSG (oxidized glutathione), SOD (superoxide dismutase), FRAP (Ferric Reducing Antioxidant Power), vitamin E, and MDA (malondialdehyde) in plasma. Results. In our study, we had 34 healthy participants (67.7% women, 30 ± 8 years old, 97% white). The 8-ISO, a biomarker of lipid peroxidation, decreased with both doses of EPP-AF® compared to baseline (8-ISO, 1.1 (0.9–1.3) versus 0.85 (0.75–0.95) and 0.89 (0.74–1.0), ng/mg creatinine, P < 0.05 , for 375 and 750 mg/d EPP-AF® doses versus baseline, mean and CI 95%, respectively). 8-OHDG, a biomarker of DNA oxidation, was also reduced compared to baseline with 750 mg/d doses (8-OHDG, 15.7 (13.2–18.1) versus 11.6 (10.2–13.0), baseline versus 750 mg/d, respectively, ng/mg creatinine, P < 0.05 ). Reduction of biomarkers of oxidative stress damage was accompanied by increased plasma SOD activity (68.8 (66.1–73.3) versus 78.2 (72.2–80.5) and 77.7 (74.1–82.6), %inhibition, P < 0.0001 , 375 and 750 mg/d versus baseline, median and interquartile range 25–75%, respectively) and by increased GSH for 375 mg/d EPP-AF® doses (1.23 (1.06–1.34) versus 1.33 (1.06–1.47), μmol/L, P < 0.05 ). Conclusion. EPP-AF® reduced biomarkers of oxidative stress cell damage in healthy humans, with increased antioxidant enzymatic capacity, especially of SOD. This trial is registered with the Brazilian Registry of Clinical Trials (ReBEC, RBR-9zmfs9).

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Section: Discussionmentioning

confidence: 82%

Antioxidant Effect of Standardized Extract of Propolis (EPP‐AF®) in Healthy Volunteers: A “Before and After” Clinical Study

Diniz

Lorencini

Berretta

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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“…High antifungal potential of propolis collected in Brazil was also revealed by other authors [ 16 , 17 , 18 ]. In addition, the groups of Santos [ 19 , 20 ] and Pina [ 21 ] successfully treated oral candidiasis with extracts of Brazilian propolis. Haghdoost reported activity of Iran propolis for which MIC and MFC values against C. albicans isolates were 360.6 μg/mL and 1250.1 μg/mL, respectively [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Antifungal Activity and Synergism with Azoles of Polish Propolis

et al. 2018

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The aim of our work was to check if one of the products of natural origin, namely honey bee propolis, may be an alternative or supplement to currently used antifungal agents. The activity of 50 ethanolic extracts of propolis (EEPs), harvested in Polish apiaries, was tested on a group of 69 clinical isolates of C. albicans. Most of the EEPs showed satisfactory activity, with minimum fungicidal concentrations (MFC) mainly in the range of 0.08–1.25% (v/v). Eradication of biofilm from polystyrene microtitration plates in 50% (MBEC50, Minimum Biofilm Eradication Concentration) required concentrations in the range of 0.04% (v/v) to more than 1.25% (v/v). High activity was also observed in eradication of biofilm formed by C. glabrata and C. krusei on the surfaces of PVC (Polyvinyl Chloride) and silicone catheters. EEPs at subinhibitory concentrations inhibited yeast-to-mycelia morphological transformation of C. albicans in liquid medium and mycelial growth on solid medium. A synergistic effect was observed for the action of EEP in combination with fluconazole (FLU) and voriconazole (VOR) against C. albicans. In the presence of EEP at concentrations as low as 0.02%, the MICs of FLU and VOR were 256 to 32 times lower in comparison to those of the drug alone. Evidence for the fungal cell membrane as the most probable target of EEPs are presented.

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“…There are few clinical studies in humans on the efficacy of extracts from Brazilian plants in the treatment of oral candidiasis. More recently, human effectiveness of Brazilian green propolis derived from B. dracunculifolia on plaque control and gingivitis [49] for the prevention and control of oral mucositis and candidiasis [147,148] and compared green propolis gel with benzydamine hydrochloride in cancer patients and irradiated in the head and neck regions [149]. Also, the Brazilian red propolis, derived from D. ecastaphyllum, both extract and gel, inhibited C. albicans in vitro, periodontopathogenic bacteria in vitro and in vivo, besides controlling periodontitis in rats [150].…”

Section: Oral Candidiasis Clinical Trial Studiesmentioning

confidence: 99%

Antifungal Activity of Brazilian Medicinal Plants against Candida Species

Santos¹,

Pereira²

2019

Candida Albicans

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Due to the resistance of Candida sp. to the usual antifungal, the demand for active principles found in the plants has been the target of diverse studies around the world. There are few in vivo and human studies on the antifungal activity of medicinal plants in the mouth. Native and imported medicinal plants, used by the Brazilian population for traditional medicine use, are the subject of study in this chapter. Thirty-eight Brazilian plants were related to information on species, family, name, used part, and medical indication of popular use. All the species mentioned had their extracts tested in vitro against C. albicans, C. tropicalis, C. krusei, C. parapsilosis, among other species that occur more frequently in the mouth. In the articles consulted, there is a great variation in Candida species tested and in minimum inhibitory concentration. The in vitro studies serve as information for the continuity of studies on the best performing plants, validate the popular belief about the use, and provide subsidies for the development of new products that are effective in the control of oral and systemic candidiasis and that are cheap and accessible for the population.

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Efficacy of Propolis on the Denture Stomatitis Treatment in Older Adults: A Multicentric Randomized Trial

Cited by 30 publications

References 57 publications

Antioxidant Effect of Standardized Extract of Propolis (EPP‐AF®) in Healthy Volunteers: A “Before and After” Clinical Study

Antioxidant Effect of Standardized Extract of Propolis (EPP‐AF®) in Healthy Volunteers: A “Before and After” Clinical Study

Antifungal Activity and Synergism with Azoles of Polish Propolis

Antifungal Activity of Brazilian Medicinal Plants against Candida Species

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