Efficacy of remote limb ischemic conditioning on poststroke cognitive impairment

Feng, Xiaoran; Huang, Lihong; Wang, Zongwen; Wang, Luojun; Du, Xunhao; Wang, Qi; Xue, Shouru

doi:10.31083/j.jin.2019.04.1192

Cited by 25 publications

(22 citation statements)

References 78 publications

(37 reference statements)

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“…The grand-average peak amplitudes and latencies of the three components were calculated separately at F3, Fz, F4, C3, Cz, C4, P3, Pz, and P4. These areas are the ones usually activated by the stimuli (Choo et al, 2005;Verweij et al, 2014;Jin et al, 2015;Lei et al, 2015;Feng et al, 2019;Ueda and Nakao, 2019;Wang et al, 2019;Khedr et al, 2020).…”

Section: Erp Preprocessingmentioning

confidence: 99%

“…P300 is the largest positive-going peak amplitude of the waveform within a time window of 300-400 ms and is considered to represent the allocation of attentional resources to rare salient stimuli (Cote et al, 2001;Marhöfer et al, 2015). P300 amplitude and latency are thought to reflect cognitive processing, such as stimulus identification and evaluation (Feng et al, 2019;Wang et al, 2019;Gao et al, 2020;Khedr et al, 2020). Studies have also suggested that higher-order cognitive stimulielicited P300 components are generated from the anterior cortex, and these components reflect the response inhibition process (de Bruijn et al, 2020;Paul et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

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Effects of Caffeine on Event-Related Potentials and Neuropsychological Indices After Sleep Deprivation

Chen

Zhang

Yang

et al. 2020

Front. Behav. Neurosci.

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Objective: Caffeine is a central nervous system stimulant that can effectively alleviate brain fatigue and low cognitive efficiency induced by total sleep deprivation (TSD). Recent studies have demonstrated that caffeine can improve subjective attention and objective behavioral metrics, such as arousal level, reaction time, and memory efficiency. However, only a few studies have examined the electrophysiological changes caused by the caffeine in humans following sleep disturbance. In this study, an event-related potential (ERP) technique was employed to measure the behavioral, cognitive, and electrophysiological changes produced by caffeine administration after TSD. Methods: Sixteen healthy subjects within-subject design performed a visual Go/No-Go task with simultaneous electroencephalogram recording. Behavioral and ERP data were evaluated after 36 h of TSD, and the effects of ingestion of either 400 mg of caffeine or placebo were compared in a double-blind randomized design. Results: Compared with placebo administration, the Go hit rates were significantly enhanced in the caffeine condition. A simple effect analysis revealed that, compared with baseline, the Go-P2 amplitude was significantly enhanced after TSD in the caffeine consumption condition. A significant main effect of the drug was found on No-Go-P2, No-Go-N2 amplitude, and Go-P2 latency before and after TSD. Conclusion: Our findings indicate that caffeine administration has acute effects on improving the efficiency of individual automatic reactions and early cognitive processes. Caffeine was related to the preservation of an individual's arousal level and accelerated response-related decisions, while subjects' higher-level recognition had limited improvement with prolonged awareness.

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Section: Erp Preprocessingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of Caffeine on Event-Related Potentials and Neuropsychological Indices After Sleep Deprivation

Chen

Zhang

Yang

et al. 2020

Front. Behav. Neurosci.

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“…In four studies, the effect of RIC was investigated in patients who were not eligible for revascularization therapies. 32 , 33 , 34 , 35 In three studies, RIC was applied as an add‐on for treatments of thrombolysis by intravenous alteplase 36 , 37 or thrombectomy. 38 One study included patients receiving additional medical treatment and patients not eligible for thrombolysis or thrombectomy.…”

Section: Resultsmentioning

confidence: 99%

“…Studies of patients who did not undergo additional revascularization initiated RIC within 24 h from stroke onset 32 or 24–72 h (with subsequent daily sessions up to 14 days 33 ). Two studies did not indicate when RIC was initiated, 34 , 35 revealing only that one inclusion criterion was a symptom onset between 4.5 h and 14 days prior to the initiation of RIC. 35 The study that included patients with and without additional medical revascularization included patients within 6 h from disease onset and had three groups.…”

Section: Resultsmentioning

confidence: 99%

Translational challenges of remote ischemic conditioning in ischemic stroke – a systematic review

Hansen

Nielsen

Christoffersen

et al. 2021

Ann Clin Transl Neurol

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Remote ischemic conditioning (RIC) has well‐established cardioprotective effects in preclinical studies and promising results in preclinical stroke research. Effective translation from preclinical studies to clinical trials has yet to be accomplished, perhaps because of the use of multiple applications of RIC (e.g., pre‐, per‐, or post‐conditioning) in preclinical studies by both invasive and non‐invasive protocols, some of which not clinically applicable. Our systematic review conformed to PRISMA guidelines and addressed differences in clinically relevant RIC applications and outcomes between preclinical and clinical studies. We retrieved a total of 30 studies (8 human; 22 animal) that met the inclusion criteria of testing clinically relevant procedures; namely, non‐invasive and per‐ or post‐conditioning protocols. Per‐conditioning was applied in 6 animal and 3 human studies, post‐conditioning was applied in 16 animal and 5 human studies, and both conditioning methods were applied in 2 animal studies. Application of RIC varied between human and animal studies regarding initiation, duration, repetition, and number of limbs included. Study designs did not systematically apply blinding, randomization, or placebo controls. On only a few occasions did preclinical studies include animals with clinically relevant comorbidities. Clinical trials were challenged by not completing the intended number of RIC cycles or addressing this deficit in the data analysis. Consistency and transferability of methods used for positive animal studies and subsequent human studies are essential for the optimal translation of results. Consensus on preclinical and clinical RIC procedures should be reached for a full understanding of the possible beneficial effects of RIC treatment in stroke.

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“…There was also a dose-dependent improvement in survival at 84 days by Kaplan-Meier analysis in separate experiments 26 . Many clinical studies also support that CRIC brings bene ts in various conditions, including healing of diabetic foot ulcer 27 , stroke recurrence in patients with symptomatic atherosclerotic intracranial arterial stenosis 28 , and cognitive domains in patients with non-cardiac ischemic stroke 29 . observed that AF recurrence in the 3 months after the PAF ablation was signi cantly lower in the RIC group than in the control group.…”

Section: Discussionmentioning

confidence: 97%

Effects of chronic remote ischemic conditioning on atrial fibrillation burden in patients with permanent pacemakers

Chen

Liu

Zhu

et al. 2020

Preprint

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Background: The burden of atrial fibrillation (AF) has been attractive recently and may be associated with stroke risk and mortality. Remote ischemic conditioning could reduce the incidence, inducibility and sustainability of AF. But the effects of chronic remote ischemic conditioning (CRIC) on atrial fibrillation burden in patients with pacemaker implanted are still unknown.Design: This was a single‑center, prospective, randomized, open-labeled clinical study.Methods: Sixty-six patients with permanent pacemakers were randomly divided into CRIC group and control group after 4 weeks screening. CRIC treatment was performed twice a day for 12 weeks. A remote ischemic conditioning protocol consisted of 4 × 5 min inflation/deflation of the blood pressure cuff applied in the upper arm to create intermittent arm ischemia. Pacemaker programming was performed for four times: before screening (-4-week), after screening and before randomization (0-week, baseline), 4-week and 12-week follow-up. Data including AF burden, longest duration of AF and cumulative numbers of atrial high-rate episodes (AHREs) were collected.Results: Sixty-one patients (31 patients in CRIC group and 30 patients in control group) completed the study. CRIC was well-tolerated by patients after 12 weeks treatment. The burden of AF in CRIC group was decreased significantly at 4-week compared with that at 0-week (14.7%±18.5% vs 17.0%±20.7%, p < 0.001), which further decreased at 12-week compared with that at 0-week (8.6%±10.2% vs 17.0%±20.7%, p < 0.001) and that at 4-week (8.6%±10.2% vs 14.7%±18.5%, p < 0.001), which was not observed in the control group. AF burden also reduced significantly after 12-week CRIC compared with that in control group (8.6%±10.2% vs 17.6%±19.5%, p = 0.013). Repeated measurement ANOVA showed that the changes of AF burden was associated with CRIC instead of time (p < 0.01). In addition, there were trends that longest duration of AF and cumulative numbers of AHREs were reduced after 12-week CRIC.Conclusions: This study suggests that a 12-week course of CRIC treatment could reduce AF burden in patients with permanent pacemakers, supporting widespread use of CRIC in the daily lives of these patients, which need to be verified in the future.Clinical Trial RegistrationRegistration name: Effects of remote ischemic conditioning on atrial fibrillation burden in patients with paroxysmal atrial fibrillationRegistration number: ChiCTR-IOR-17012666Registered 14 September 2017; URL: www.chictr.org.cn/showproj.aspx?proj=21591

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Efficacy of remote limb ischemic conditioning on poststroke cognitive impairment

Abstract: J o u r n a l o f I n t e g r a t i v e N e u r o s c i e n c e

Cited by 25 publications

References 78 publications

Effects of Caffeine on Event-Related Potentials and Neuropsychological Indices After Sleep Deprivation

Effects of Caffeine on Event-Related Potentials and Neuropsychological Indices After Sleep Deprivation

Translational challenges of remote ischemic conditioning in ischemic stroke – a systematic review

Effects of chronic remote ischemic conditioning on atrial fibrillation burden in patients with permanent pacemakers

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