Efficacy of several additives to modulate the phase behavior of biomedical polymers: A comprehensive and comparative outlook

Narang, Payal; Venkatesu, Pannuru

doi:10.1016/j.cis.2019.102042

Cited by 8 publications

(4 citation statements)

References 143 publications

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“…Osmolytes are cosolvents in the sense that they have the potential to alter solvent properties in a mixture. Also, possibly, they have the capability to tune the hydrophilicity–hydrophobicity ratio owing to the disruption of H-bond interaction among water molecules and the hydrophilic segment of the polymer . From our observations, it was observed that as the concentration of urea was increased from 0.3 to 3 M, the CMT of P-407 increased from 27.5 to 32.5 °C.…”

Section: Resultsmentioning

confidence: 65%

How Kosmotropic and Chaotropic Osmolytes Perturb the Properties of an Aqueous Solution of a Pluronic Block Copolymer?

2022

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Poloxamer 407 (P-407) composed of a poly(ethylene glycol)–block-poly(propylene glycol)–block-poly(ethylene glycol) (PEG–PPG–PEG) unit has two distinct microenvironments: the interior core formed by the PPG unit and the exterior shell formed by the PEG unit. In this work, we have used two fluorescent molecules coumarin-153 and 8-anilino-1-naphthalene sulfonic acid (ANS) of contrasting natures to characterize and probe the water dynamics in the core and corona regions of the copolymer by means of spectroscopic techniques, namely, absorption, fluorescence, and time-resolved fluorescence emission spectroscopy and Fourier transform infrared (FTIR) spectroscopy. Changes in the surface morphologies were characterized by using microscopic techniques. Further, two classes of osmolytes kosmotropic (betaine and sarcosine) and chaotropic (urea) known to perturb the water structure were added to aqueous solutions of P-407. Our studies reveal that the addition of kosmotropes decreases the critical micelle temperature (CMT) of the copolymer, whereas the chaotropic osmolyte increases the CMT. Steady-state studies reveal that the addition of the osmolytes to the copolymer increases the polarity of the micelle formed and hence results in the red shift in the ANS absorbance maximum. FTIR spectroscopy reveals that kosmotropes interact with the PEG moiety of the copolymer, whereas the chaotrope interacts with both the PEG and PPG moieties of the copolymer. Solvent relaxation studies produced less changes upon the addition of the kosmotropes, whereas a greater change in the relaxation time was observed in the presence of the chaotrope.

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Section: Resultsmentioning

confidence: 65%

How Kosmotropic and Chaotropic Osmolytes Perturb the Properties of an Aqueous Solution of a Pluronic Block Copolymer?

2022

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“…Consequently, the soluble forms of the polymer are more favorable. 90,91 The UCST comparison between of polysulfopropylbetaine methacrylate (PSPB) and polysulfobutylbetaine methacrylate (PSBB) suggests that increasing the methylene chain length between the ammonium and the sulfonate moieties substantially increased the UCST temperature. 64 On the other hand, it has also been shown that lengthening methylene chain length between the backbone and the ammonium groups in poly(sulfobetaines) caused drastic decrease in UCST.…”

Section: Polymer Materialsmentioning

confidence: 99%

Molecular bases for temperature sensitivity in supramolecular assemblies and their applications as thermoresponsive soft materials

et al. 2022

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“…Thermosensitive polymers, as a subclass of smart polymers, undergo a temperature-induced reversible sol–gel transition when polymer aqueous solutions are heated or cooled ( El-Zaafarany et al, 2018 ). The design of thermosensitive nanomaterials with a good temperature response and their ability to exhibit coil to ball transition behavior when approaching physiological temperature, which make them more promising materials in the field of biomaterials and biomedicine ( Narang and Venkatesu, 2019 ). Therefore, this review focuses on thermosensitive nanomaterials.…”

Section: Introductionmentioning

confidence: 99%

Nanomaterials based on thermosensitive polymer in biomedical field

et al. 2022

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The progress of nanotechnology enables us to make use of the special properties of materials on the nanoscale and open up many new fields of biomedical research. Among them, thermosensitive nanomaterials stand out in many biomedical fields because of their “intelligent” behavior in response to temperature changes. However, this article mainly reviews the research progress of thermosensitive nanomaterials, which are popular in biomedical applications in recent years. Here, we simply classify the thermally responsive nanomaterials according to the types of polymers, focusing on the mechanisms of action and their advantages and potential. Finally, we deeply investigate the applications of thermosensitive nanomaterials in drug delivery, tissue engineering, sensing analysis, cell culture, 3D printing, and other fields and probe the current challenges and future development prospects of thermosensitive nanomaterials.

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Efficacy of several additives to modulate the phase behavior of biomedical polymers: A comprehensive and comparative outlook

Cited by 8 publications

References 143 publications

How Kosmotropic and Chaotropic Osmolytes Perturb the Properties of an Aqueous Solution of a Pluronic Block Copolymer?

How Kosmotropic and Chaotropic Osmolytes Perturb the Properties of an Aqueous Solution of a Pluronic Block Copolymer?

Molecular bases for temperature sensitivity in supramolecular assemblies and their applications as thermoresponsive soft materials

Nanomaterials based on thermosensitive polymer in biomedical field

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