Efficacy of Topical Clobetasol Propionate 0.05% Ointment and Topical Tacrolimus 0.1% Ointment in Treatment of Alopecia Areata.: RCT

Abstract

Background: Non-scarring hair loss from the scalp or body occurs as a result of alopecia areata. It is the most prevalent autoimmune disorder. Aims: To compare the efficacy of topical clobetasol propionate 0.05% ointment and topical tacrolimus 0.1% ointment in the management of localized alopecia areata. Study design: Randomized control trial. Methodology: All patients (n=116) having alopecia areata of the scalp were included. SALT Score was calculated at presentation. Group A received topical clobetasol propionate 0.05% ointment applied twice daily over the alopecia patch and group B received topical tacrolimus 0.1% twice daily for 3 months. Patients were followed in OPD at 1month, 2months and 3months interval to ensure compliance. All this information was recorded on Performa. Data was analyzed using SPSS version 26. Efficacy of both groups was compared using Chi square test and keeping P-value of ≤ 0.05 as significant. Results: As per efficacy, in Group A, 46 (79.31%) patients showed effective results whereas in Group B only 26 (44.82%) patients showed effective results with a significant P-value of 0.00013. Conclusion: It was concluded that topical clobetasol propionate 0.05% ointment was more effective as a treatment option in promoting hair re-growth among patients of alopecia areata. Keywords: Alopecia Areata, Tacrolimus, Clobetasol Propionate and Hair Re-growth

Comparative evaluation of the efficacy of topical tacrolimus 0.03% and topical calcipotriol 0.005% mixed with betamethasone dipropionate versus topical clobetasol 0.05% in treatment of alopecia areata: A clinical and trichoscopic study

“…A polarized dry contact approach was applied to detect the characteristic trichoscopic features of AA. The Alopecia Areata Predictive Score (AAPS) was applied as a trichoscopy‐based predictive tool of the treatment outcome 13 …”

“…While upright regrowing and pigtail hairs are considered positive predictive markers given a score of +1, black dots, exclamation mark hairs, tapered, and broken hairs are considered negative predictive markers and given a score of −1. Patients with scores 2, 1, 0, −1, −2, −3, and − 4 are given a probability of hair regrowth of 98.3%, 88.7%, 52.3%, 13.2%, 2.1%, 0.3%, and 0% respectively 13 …”

“…The Alopecia Areata Predictive Score (AAPS) was applied as a trichoscopy-based predictive tool of the treatment outcome. 13 AAPS is calculated 2 months after initiation of therapy according The study was conducted in 60 patients who had completed both the treatment and follow-up phases. There was no statistically significant difference between the three groups regarding age and sex of the patients.…”

“….3%, 88.7%, 52.3%, 13.2%, 2.1%, 0.3%, and 0% respectively 13. Statistical Analysis: Data were checked, entered, and analyzed using SPSS version 23 for data processing.The following statistical methods were used for analysis of results of the present study: arithmetic mean, standard deviation, Student's t-test, Mann-Whitney test, chi-square test, Z-test for percentage, and odds ratio.…”

Efficacy of Oral Apremilast in The Treatment of Alopecia Areata, at The Tertiary Care Hospital, Karachi

“…The impact of AA on physical appearance can lead to significant psychological distress, manifesting as social phobia, anxiety, and depression (10). Treatment modalities vary, including steroids (intra-lesionally, topically, or systemically), topical retinoids, systemic immune-modulating drugs, photo-chemotherapy, contact immunotherapy, anthralin, calcineurin inhibitors, minoxidil, dermatographia wigs, and hypnotherapy (11)(12). Recently, Apremilast, an oral phosphodiesterase 4 (PDE4) inhibitor, emerged as a promising treatment for various inflammatory skin conditions, including AA and psoriasis.…”