Efficacy Ozone Therapy in Reducing Periodontal Disease

Tetè, Giulia; D'Amicantonio, Teresa; Polizzi, Elisabetta

doi:10.3390/ma16062375

Cited by 7 publications

(4 citation statements)

References 40 publications

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“…When ozone is applied to the oral cavity, it can exert antimicrobial effects by disrupting the cell walls of microorganisms and interfering with their metabolic processes. This makes ozone an attractive option for treating infections caused by periodontal pathogens and Candida species, which are known to play significant roles in periodontal disease and oral thrush, respectively [ 92 , 93 , 94 , 95 ]. Several research papers have reported positive outcomes when using ozone therapy in conjunction with conventional dental treatments.…”

Section: The Uses Of Ozone In Dentistrymentioning

confidence: 99%

Ozone Therapy in Medicine and Dentistry: A Review of the Literature

2023

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Ozone has been successfully used in medicine for over 100 years due to its microbiological qualities. Its powerful oxidation impact, which results in the production of free radicals, and its ability to cause the direct death of nearly all microorganisms is the basis for its bactericide, virucide, and fungicide properties. Ozone also has a medicinal impact that speeds up blood flow and aids wound healing. Ozone may be applied as a gas or dissolved in water for medical purposes. Despite the benefits of using ozone therapeutically, concerns about its use in dentistry still exist. We aimed to provide a summary of the current uses of ozone in medicine and dentistry. An electronic search was performed for all English scientific papers published between 2012 and 2023 using PubMed, Cochrane, and Google Scholar search engines. Ozone, clinical applications, medicine, and dentistry were the search terms used. Seventy full-text articles describing the use of ozone therapy in medicine and dentistry were included in the present review. Ozone has shown several beneficial effects in the medical field. However, despite the encouraging in vitro evidence, the clinical use of ozone in dentistry has not yet been demonstrated as highly effective.

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Section: The Uses Of Ozone In Dentistrymentioning

confidence: 99%

Ozone Therapy in Medicine and Dentistry: A Review of the Literature

2023

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“…Ozone, composed of three oxygen atoms, rapidly breaks down into oxygen, with one oxygen atom serving as a potent oxidant that can eliminate microorganisms and activate antioxidant enzymes ( 6 ). Studies have demonstrated the application of ozone therapy in various conditions, including periodontitis, pain management, tumors, and diabetic wounds ( 7 – 10 ). As an adjunct therapy for DFUs, the effectiveness of ozone therapy varies.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the healing potential of short-term ozone therapy for the treatment of diabetic foot ulcers

Sun,

Heng,

Liu

et al. 2024

Front. Endocrinol.

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BackgroundThe availability of research on short-term ozone therapy for diabetic foot ulcers (DFUs) is limited, and even when it is accessible, it mainly comprises of basic analysis conducted during long-term ozone therapy. This study was to evaluate the efficacy of short-term ozone therapy in promoting wound healing in DFUs.MethodsA retrospective analysis was conducted on 89 patients with type 2 diabetes complicated by DFUs. The patients were divided into two groups: ozone therapy group (n=41) and control group (n=48). Wound condition, change of bacterial types, changes in inflammatory indicators (erythrocyte sedimentation rate [ESR], C-reactive protein [CRP], and procalcitonin [PCT]), vascular endothelial growth factor (VEGF), cytokines [Interleukin 6 (IL-6) and tumor necrosis factor-α(TNF-α)], and oxidative stress levels (superoxide dismutase [SOD], malondialdehyde [MDA], and total antioxidant capacity [T-AOC]) were observed pre-treatment and after 1 week. After a 12-week of follow-up, wound healing rate, amputation rate, inpatient day, duration of antibiotics, reinfection rate, incidence of new ulcers, readmission rate, and reoperation rate, and cumulative wound healing rate using Kaplan-Meier curves were assessed.ResultsAfter 1 week of treatment, the ozone therapy group showed higher VEGF, SOD, and T-AOC levels compared to the control group (P<0.05), while CRP, PCT, ESR, IL-6, TNF-α, MDA levels and bacterial types were lower (P<0.05). The ozone therapy group had a higher wound healing rate after a 12-week follow-up (P<0.05). Kaplan-Meier curves indicated a higher cumulative wound healing rate in the ozone therapy group (P<0.05). Additionally, the ozone therapy group had lower inpatient day, duration of antibiotics, reinfection rate, and readmission rate compared to the control group (P<0.05).ConclusionShort-term ozone therapy is effective in promoting wound healing in DFUs by reducing inflammation, increasing growth factor levels, improving oxidative stress status, shortening healing time, and improving long-term prognosis. These findings suggest the potential of short-term ozone therapy as a valuable treatment modality for DFUs.

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“…However, numerous other approaches have been described in the literature to increase the effectiveness of non-surgical therapy, such as ozone, the addition of erythritolchlorhexidine powder, probiotics, laser therapy, hyaluronic acid, omega-3, omega-6, and drugs such as antibiotics or other medications [30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45].…”

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confidence: 99%