Efficient antioxidant capacity against lipid peroxide levels in healthy elderly of Mexico City

Particulate air pollution, systemic oxidative stress, inflammation, and atherosclerosis

“…Measures of oxidation in circulating blood are highly relevant since they may imply the involvement of oxidatively modified plasma lipoproteins such as LDL and/or high-density lipoprotein (HDL), key players in the promotion or protection from atherosclerosis, respectively (Araujo and Nel 2009). Liu et al (2009) reported the association of increases in exposure to black carbon and PM 2.5 with elevation in plasma levels of thiobarbituric acid reactive substances (TBARS) of 28 nonsmoking seniors, in agreement with earlier reports of increased serum TBARS in association with PM 2.5 (Sorensen et al 2003) or after moving or living in a polluted urban location such as Mexico city (Medina-Navarro et al 1997; Sanchez-Rodriguez et al 2005). Experimental animal work brings support to the causality notion.…”

Relationship between oxidative stress and cognitive impairment in the elderly of rural vs. urban communities

“…This contrasts with previous reports indicating that healthy elderly individuals have higher oxidative DNA damage and higher antioxidant levels as a compensatory antioxidant response to OxS (Mendoza-Nú ñez et al, 2001), and that the elderly in Mexico City have efficient antioxidant capacity against high lipid peroxide levels (Sánchez-Rodríguez et al, 2005). Even so, lower antioxidant activity has also been reported in the elderly who have CI (Rinaldi et al, 2003).…”

Association between oxidative stress and nutritional status in the elderly

“…They confirmed previous results showing that in comparison with elderly individuals in rural areas there was greater lipid peroxidation in individuals in urban areas, together with greater cognitive decline, indicating that residing in urban areas in comparison with rural areas may represent a risk factor for an increase in lipid peroxidation and cognitive decline. The apparently unexpected antioxidant behavior 40 , had already been pointed out by other authors 38,42 , who suggested that aging should not necessarily be associated with an overall decline in antioxidant capacity as, despite the activity of some antioxidants declining with age, the activity of others remains the same or increases. However, the behavior of the antioxidant defense system in the elderly faced with the increase in oxidation of biomolecules is a thesis still subject to debate and study.…”

“…37 Recently, antioxidant activity and the levels of lipid peroxidation have been examined in the elderly and adults resident in both rural and urban areas. 40 The authors verified that the elderly population resident in the urban area showed lipid peroxidation -thiobarbituric acid reactive substances (TBARS) -and total antioxidant status (TAS) higher than the same population in the rural area, as well as higher SOD enzyme activity and lower GSH-Px enzyme activity. The same group of researchers 41 examined the relationship between the level of oxidative stress and cognitive decline in elderly individuals in urban and rural areas.…”