Efficient drug delivery potential and antimicrobial activity of biocompatible hydrogels of dextrin/Na-alginate/PVA

Nazir, Arif; Abbas, Mazhar; Kainat, Faiza; Iqbal, Dure Najaf; Aslam, Farheen; Kamal, Abida; Mohammed, Osama A.; Zafar, Kinza; Alrashidi, Amal Abdullah; Alshawwa, Samar Z.; Iqbal, Munawar

doi:10.1016/j.heliyon.2024.e29854

Cited by 4 publications

(1 citation statement)

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“…Nazir, A., et al; 2024 explained the mechanism of hydrogel biodegradation based upon the extent of crosslinking. Higher levels of crosslinking increased the network stability of hydrogels and decreased their biodegradation rate, while low crosslinking and high pore size facilitated the degrading agent reaching the polymer chains and inducing degradation earlier [ 46 ].…”

Section: Resultsmentioning

confidence: 99%

Design and Characterization of Chitosan-Based Smart Injectable Hydrogel for Improved Sustained Release of Antinarcotics

Aftab,

Javed,

Haider

et al. 2024

Pharmaceuticals

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The treatment adherence of narcotics-addicted individuals with reduced incidences of relapse can be enhanced by a sustained drug release formulation of antinarcotics. So far, different drug formulations have been reported with sustained drug release periods of 28 and 35 days. To further enhance this duration, different formulations of injectable hydrogels (IHs) have been developed by combining low molecular weight (LMW) and high molecular weight (HMW) chitosan (CS) with guar gum (GG) and crosslinking them by sodium bi phosphate dibasic. The structural, morphological, and physicochemical properties of LMW-CS IH, and HMW-CS IH were evaluated using Fourier transform infrared spectroscopy (FT-IR), thermo-gravimetric analysis (TGA), scanning electron microscopy (SEM), and rheological, swelling, and biodegradation analysis. The HMW-CS IH showed high crosslinking, increased thermal stability, high mechanical strength, elevated swelling, and low biodegradation. The antinarcotic drugs naltrexone (NTX) and disulfiram (DSF) were loaded separately into the HMW-CS IH and LMW-CS IH. The release of NTX and DSF was investigated in phosphate buffer saline (PBS) and ethanol (0.3%, 0.4%, and 0.5%) over a 56-day period using an UV spectrophotometer. The drug release data were tested in zero-order, first-order, and Korsemeyer–Peppas mathematical models. In PBS, all prepared formulations followed non-Fickian drug release, while in ethanol, only NTX HMW-CS IH followed non-Fickian release in all three different concentrations of ethanol.

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Section: Resultsmentioning

confidence: 99%