Efficient esterification of curcumin in bis(trifluoromethylsulfonyl)imide-based ionic liquids

Gano, Marcin; Klebeko, Joanna; Pełech, Robert

doi:10.1016/j.molliq.2021.116420

Cited by 7 publications

(6 citation statements)

References 44 publications

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“…At the end of the reaction, depressurized filtration was performed to separate the ionic liquid from the reaction mixture. The filtrate containing ionic liquid was washed three times with ethyl acetate and then dried in a vacuum dryer for 24 h at 50 °C in preparation for the second cycle [ 30 ]. Sangwan et al synthesized 1,8-dioxooctahydroxanthene derivative (3a–3k) using ILs 1-butyl-3-methylimidazoliumtetrafluoroborate (BMIF), 1-butyl-3-methylimidazoliumbromide (BMIB), and 1-butyl-3-methylimidazoliumchloride (BMIC) without a solvent.…”

Section: Ionic Liquids In Pharmaceutical Applicationsmentioning

confidence: 99%

Ionic Liquids in Pharmaceutical and Biomedical Applications: A Review

Zhuo,

Cheng,

Zhao

et al. 2024

Pharmaceutics

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The unique properties of ionic liquids (ILs), such as structural tunability, good solubility, chemical/thermal stability, favorable biocompatibility, and simplicity of preparation, have led to a wide range of applications in the pharmaceutical and biomedical fields. ILs can not only speed up the chemical reaction process, improve the yield, and reduce environmental pollution but also improve many problems in the field of medicine, such as the poor drug solubility, product crystal instability, poor biological activity, and low drug delivery efficiency. This paper presents a systematic and concise analysis of the recent advancements and further applications of ILs in the pharmaceutical field from the aspects of drug synthesis, drug analysis, drug solubilization, and drug crystal engineering. Additionally, it explores the biomedical field, covering aspects such as drug carriers, stabilization of proteins, antimicrobials, and bioactive ionic liquids.

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Section: Ionic Liquids In Pharmaceutical Applicationsmentioning

confidence: 99%

Ionic Liquids in Pharmaceutical and Biomedical Applications: A Review

Zhuo,

Cheng,

Zhao

et al. 2024

Pharmaceutics

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“…Ionic liquids (ILs), as a new and effective reaction medium (solvent/catalyst), have become a hot research object in today's green chemical industry because of their unique advantages. [23][24][25][26][27][28][29][30][31] However, usually a large amount of IL is required, and its recyclability is not as convenient as solid catalysts. In order to separate IL catalysts more conveniently, IL-based solid catalysis has attracted much attention.…”

Section: Introductionmentioning

confidence: 99%

Sulfonated phenylamine ionic liquids as efficient phase-separation catalysts for the synthesis of trimethylolpropane triacrylate

Zhang

2023

New J. Chem.

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“…The study concentrates on modeling the gas-ionic liquid partition coefficients for three organic compounds hexane, cyclohexane and benzene in the series of ionic liquids with common bis(trifluoromethylsulfonyl)imide ([Tf2N] − ) anion using linear and non-linear QSPR methods. [Tf2N] + ILs are being extensively studied for various applications, for example as a media for supercapacitors [ 63 ], a heavy metal adsorbent [ 64 ], an anticancer agent [ 65 ] and gas solvent in sensors [ 66 ] among many other applications [ 67 , 68 , 69 ]. Variation in ionic counterpart makes it possible more specifically to understand how molecular interactions of partitioning by the ionic liquid and how to enable finding the application-appropriate ionic liquid.…”

Section: Introductionmentioning

confidence: 99%

Machine Learning Quantitative Structure–Property Relationships as a Function of Ionic Liquid Cations for the Gas-Ionic Liquid Partition Coefficient of Hydrocarbons

Toots

Sild

Leis

et al. 2022

IJMS

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Ionic liquids (ILs) are known for their unique characteristics as solvents and electrolytes. Therefore, new ILs are being developed and adapted as innovative chemical environments for different applications in which their properties need to be understood on a molecular level. Computational data-driven methods provide means for understanding of properties at molecular level, and quantitative structure–property relationships (QSPRs) provide the framework for this. This framework is commonly used to study the properties of molecules in ILs as an environment. The opposite situation where the property is considered as a function of the ionic liquid does not exist. The aim of the present study was to supplement this perspective with new knowledge and to develop QSPRs that would allow the understanding of molecular interactions in ionic liquids based on the structure of the cationic moiety. A wide range of applications in electrochemistry, separation and extraction chemistry depends on the partitioning of solutes between the ionic liquid and the surrounding environment that is characterized by the gas-ionic liquid partition coefficient. To model this property as a function of the structure of a cationic counterpart, a series of ionic liquids was selected with a common bis-(trifluoromethylsulfonyl)-imide anion, [Tf2N]−, for benzene, hexane and cyclohexane. MLR, SVR and GPR machine learning approaches were used to derive data-driven models and their performance was compared. The cross-validation coefficients of determination in the range 0.71–0.93 along with other performance statistics indicated a strong accuracy of models for all data series and machine learning methods. The analysis and interpretation of descriptors revealed that generally higher lipophilicity and dispersion interaction capability, and lower polarity in the cations induces a higher partition coefficient for benzene, hexane, cyclohexane and hydrocarbons in general. The applicability domain analysis of models concluded that there were no highly influential outliers and the models are applicable to a wide selection of cation families with variable size, polarity and aliphatic or aromatic nature.

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Efficient esterification of curcumin in bis(trifluoromethylsulfonyl)imide-based ionic liquids

Cited by 7 publications

References 44 publications

Ionic Liquids in Pharmaceutical and Biomedical Applications: A Review

Ionic Liquids in Pharmaceutical and Biomedical Applications: A Review

Sulfonated phenylamine ionic liquids as efficient phase-separation catalysts for the synthesis of trimethylolpropane triacrylate

Machine Learning Quantitative Structure–Property Relationships as a Function of Ionic Liquid Cations for the Gas-Ionic Liquid Partition Coefficient of Hydrocarbons

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