This paper presents an isogeometric boundary element method (IGABEM) for transient heat conduction analysis. The Non-Uniform Rational B-spline (NURBS) basis functions, which are used to construct the geometry of the structures, are employed to discretize the physical unknowns in the boundary integral formulations of the governing equations. Bézier extraction technique is employed to accelerate the evaluation of NURBS basis functions. We adopt a radial integration method to address the additional domain integrals. The numerical examples demonstrate the advantage of IGABEM in dimension reduction and the seamless connection between CAD and numerical analysis.