“…However, during minimally-invasive interventions the bone surface in the regions around the relevant anatomical landmarks might not be exposed, and digitization of those points by means of mechanical devices then increases the invasiveness [8]. Moreover, as precise localization of the anatomical landmarks in CT images and in physical space is difficult, only moderate registration accuracy can be expected [24]. In contrast, surface-based registration does not require artificial markers and avoids the problem of precise manual landmark localization.…”