Efficient preparation and improved sensitivity of molecularly imprinted polymers using room temperature ionic liquids

Booker, Katherine; Bowyer, Michael C.; Holdsworth, Clovia I.; McCluskey, Adam

doi:10.1039/b517886j

Cited by 71 publications

(62 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results provide a good foundation for the current study (Booker et al 2007). Previous research conducted by our group indicated that a change in the anion of the RTIL used as polymerisation solvent (from BF 4 -to PF 6 -) influences polymer selectivity for the template for both trans-aconitic acid and cocaineimprinted polymers (Booker et al, 2005(Booker et al, , 2006(Booker et al, , 2008 (Booker et al 2006(Booker et al , 2007Wang et al 2006Wang et al , 2008He et al 2008). The work reported herein aims to identify RTILs that reproducibly create well-performing MIPs, and assess factors contributing to variations in polymer performance.…”

Section: Scope Of This Studymentioning

confidence: 52%

“…This results from later phase separation of the growing polymer chains, resulting in a lower degree of aggregation of the polymer particles. Generally, RTIL prepared MIPs and NIPs have been observed to swell less (Booker et al, 2006). It is important to note here though, that the absence of polymer swelling does not preclude the development of high specificity, high capacity MIPs.…”

Section: Mip Swellingmentioning

confidence: 91%

“…In the case of VOCs, minimal amounts of porogen (5 mL) produce monolithic polymers, whereas high porogen volume (25 mL) promotes the formation of polymer nanoparticles (Castell et al 2006). The effect of porogen volume on MIP morphology and selectivity has been documented in both VOCs and RTILs (Booker et al 2006;Kotrotsiou et al 2009).…”

Section: Scope Of This Studymentioning

confidence: 99%

“…The tunable solvating properties of ionic liquids hold considerable potential to facilitate an increase in favorable T-FM interactions, whilst limiting those associated with non-specific binding. An additional attraction of RTILs as porogens is the considerable body of literature pertaining to polymerization rate enhancements (which allows precipitation polymerization approaches to be applied in a short time frame), and our earlier studies that showed an enhancement of MIP selectivity relative to the identical MIP formulation manufactured in a traditional VOC porogen (Booker et al 2006(Booker et al , 2007.…”

mentioning

confidence: 99%

“…More recently, efforts have focused on garnering a greater understanding of the influence of the template on MIP morphology and function, as well as the role of the porogen in the initial MIP synthesis. In this latter regard, we are one of the few groups who have explored the potential use of room temperature ionic liquids as porogen (Booker et al 2006(Booker et al , 2007Wang 2006Wang , 2008He 2008). The tunable solvating properties of ionic liquids hold considerable potential to facilitate an increase in favorable T-FM interactions, whilst limiting those associated with non-specific binding.…”

mentioning

confidence: 99%

See 4 more Smart Citations

Ionic Liquids as Porogens in the Synthesis of Molecularly Imprinted Polymers

Booker¹,

Holdsworth²,

Bowyer³

et al. 2011

Applications of Ionic Liquids in Science and Technology

Self Cite

View full text Add to dashboard Cite

Section: Scope Of This Studymentioning

confidence: 52%

Section: Mip Swellingmentioning

confidence: 91%

Section: Scope Of This Studymentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Ionic Liquids as Porogens in the Synthesis of Molecularly Imprinted Polymers

Booker¹,

Holdsworth²,

Bowyer³

et al. 2011

Applications of Ionic Liquids in Science and Technology

Self Cite

View full text Add to dashboard Cite

A Room Temperature Ionic Liquid (RTIL)‐Mediated, Non‐Hydrolytic Sol–Gel Methodology to Prepare Molecularly Imprinted, Silica‐Based Hybrid Monoliths for Chiral Separation

et al. 2006

View full text Add to dashboard Cite

Molecular Imprinting: Green Perspectives and Strategies

et al. 2021

View full text Add to dashboard Cite

Large quantities of organic solvents and reagents are usually required in the fabrication of these materials. Moreover, the use of excess reagents in solvent extraction, purification, filtration/ centrifugation, and cleaning processes is essential for adequate product purity. Because of the numerous practical applications of advanced materials, some are synthesized on a large scale and commercialized. [3] The excessive consumption of nonrenewable, hazardous chemicals is an unsustainable practice and a prominent criticism of these materials. Nonetheless, the use of advanced materials in sensing applications, medicine, electronics, and catalysis is inevitable. [4] During various research activities, such as fabricating advanced materials, as well as in the subsequent stage, i.e., industrial operations, new challenges have arisen that impact not only almost every aspect of human life but also other living creatures and ecosystems. It is estimated that the impact of these practices will endure into the next century. [5] Since the advancement of science, industry, and technology is inevitable, scientists have been persuaded to search for methods to counteract or minimize the negative impacts of human activities. [6] Thus, green chemistry has advanced and green principles have been defined for most sciences, including synthesis, [7] analytical chemistry, [8] engineering, [9] and pharmaceutical science. [10] Fortunately, contemporary society has great awareness of deleterious environmental side effects, resulting in a sense Advances in revolutionary technologies pose new challenges for human life; in response to them, global responsibility is pushing modern technologies toward greener pathways. Molecular imprinting technology (MIT) is a multidisciplinary mimic technology simulating the specific binding principle of enzymes to substrates or antigens to antibodies; along with its rapid progress and wide applications, MIT faces the challenge of complying with green sustainable development requirements. With the identification of environmental risks associated with unsustainable MIT, a new aspect of MIT, termed green MIT, has emerged and developed. However, so far, no clear definition has been provided to appraise green MIT. Herein, the implementation process of green chemistry in MIT is demonstrated and a mnemonic device in the form of an acronym, GREENIFICATION, is proposed to present the green MIT principles. The entire greenificated imprinting process is surveyed, including element choice, polymerization implementation, energy input, imprinting strategies, waste treatment, and recovery, as well as the impacts of these processes on operator health and the environment. Moreover, assistance of upgraded instrumentation in deploying greener goals is considered. Finally, future perspectives are presented to provide a more complete picture of the greenificated MIT road map and to pave the way for further development.

show abstract

Efficient preparation and improved sensitivity of molecularly imprinted polymers using room temperature ionic liquids

Cited by 71 publications

References 18 publications

Ionic Liquids as Porogens in the Synthesis of Molecularly Imprinted Polymers

Ionic Liquids as Porogens in the Synthesis of Molecularly Imprinted Polymers

A Room Temperature Ionic Liquid (RTIL)‐Mediated, Non‐Hydrolytic Sol–Gel Methodology to Prepare Molecularly Imprinted, Silica‐Based Hybrid Monoliths for Chiral Separation

Molecular Imprinting: Green Perspectives and Strategies

Contact Info

Product

Resources

About