Efficient stabilization of natural curcuminoids mediated by oil body encapsulation

Abstract

Curcumin is a natural hydrophobic polyphenol found in the powdered rhizomes of Curcuma longa. Due to its capacity to interfere with many signalling pathways, it has been shown that curcumin has potential beneficial pharmacological effects including antioxidant, anti-inflammatory, anticarcinogenic properties.However, the use of curcumin is fairly restricted because of its poor water solubility, low bioavailability, inadequate tissue absorption and degradation at alkaline pH. In the present contribution, we first verified the anti-proliferative effects of natural curcuminoids towards two different cell lines derived from an ovarian and a breast adenocarcinoma cancer. Later, curcuminoids were successfully encapsulated into reconstituted oil bodies. Once encapsulated into the triacylglycerol cores of the reconstituted oil bodies, curcumin, the most hydrophobic and active of the three curcuminoids, was better stabilized in comparison with albumin stabilization. Oil body encapsulated curcuminoids showed the same effects on cancer cell viability as the free drug, confirming the great potential of natural oil bodies as micro/nano-capsules in drug delivery applications.

Administration of Reconstituted Polyphenol Oil Bodies Efficiently Suppresses Dendritic Cell Inflammatory Pathways and Acute Intestinal Inflammation

“…OBs were extracted from almond seeds. OB purification was carried out by a two-layer flotation procedure as previously reported [22] , and a further purification step was performed consisting of two sequential washings with 2.0 M NaCl. OBs were finally resuspended in 150 mM Tris–HCl, pH 7.5, containing 0.6 M sucrose.…”

“…According to the relative proportions of triacylglycerols (TAGs), PLs, and proteins, stable OBs can be technically reconstituted with these three essential constituents [21] . Reconstituted oil bodies (ROBs), as well as native OBs, have been previously reported as useful vehicles for the stabilization of curcumin, another polyphenol [22] .…”

Curcuminoids combined with gefitinib mediated apoptosis and autophagy of human oral cancer SAS cells in vitro and reduced tumor of SAS cell xenograft mice in vivo

“…DMC or BDMC are more stable than CUR in physiological medium and both possess anti‐inflammation and anticancer activities . DMC inhibited prostate cancer cell proliferation via AMP‐activated protein kinase (AMPK)‐induced downregulation of heat shock protein (HSP) 70 and epidermal growth factor receptor (EGFR) .…”

A highly selective nanocomposite based on MIP for curcumin trace levels quantification in food samples and human plasma following optimization by central composite design

“…Curcumin (phytochemical polyphenol) as main pigment of ginger herbal extracts (Zingiber officinale) and turmeric (Curcuma longa) known as functional food source in the nutritive industry [5][6][7]. Curcumin (principal curcuminoid of spice turmeric) with two other compounds like desmethoxycurcumin and bis-desmethoxycurcumin) [8][9][10] exhibit a keto-enol tautomerism [11,12] and therefore have diverce reactivity. Its daily application as condiment and spice has chemopreventive and chemotherapeutic which candidate it for treatment of ailments such as lung cancer, skin and liver diseases [13][14][15].…”