Efficient Syntheses of ω-Trifluoromethyl Substituted ω-Amino Acids

Abstract

Syntheses of N-protected b-trifluoromethyl-b-amino acids, g-trifluoromethyl-g-amino acids, d-trifluoromethyl-d-amino acids, and b-trifluoromethyl-b-amino-a-hydroxy acids (4,4,4-trifluoroisothreonine) starting from N-acyl-1-chloro-2,2,2-trifluoroethylamines are described.