Efficient synthesis, crystallography study, antibacterial/antifungal activities, DFT/ADMET studies and molecular docking of novel α-aminophosphonates

Bahadi, Rania; Berredjem, Malika; Benzaid, Chahrazed; Bouchareb, Fouzia; Dekir, Ali; Djendi, Manel Lina; Ibrahim-Ouali, Malika; Boussaker, Meriem; Bouacida, Sofiane; Bhat, Ajmal Rashid; Ahmed, Sumeer; Bachari, Khaldoun; Redjemia, Rayenne

doi:10.1016/j.molstruc.2023.135849

Journal of Molecular Structure

2023

DOI: 10.1016/j.molstruc.2023.135849

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Efficient synthesis, crystallography study, antibacterial/antifungal activities, DFT/ADMET studies and molecular docking of novel α-aminophosphonates

Rania Bahadi,

Malika Berredjem,

Chahrazed Benzaid

et al.

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Cited by 11 publications

References 40 publications

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Phosphorus Heterocycles and Their Biological Applications

Kumar,

Mukhopadhyay,

Bhagat

2024

ChemistrySelect

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Life of the living organism is based on phosphorous, and it is involved in almost all important biological and biochemical processes such as energy transfer, bone development and storing genetic information. Many of the therapeutic agents having C─P bond, isolated naturally as well and widely used in daily clinical practices are phosphorus‐containing drugs (e.g: phosphotriesters, phosphonates, phosphinates, phosphine oxides, phosphoric amides, bisphosphonates, phosphoric anhydrides, etc.) and growing further. The phosphorus heterocycles (PHs) integrate the merits of both phosphorus atom and heterocyclic scaffolds representing an important class of organophosphorus compounds, which are constantly drawing the attention among both industrial and scientific society as these compounds have shown varieties of related applications. Owing to its seminal biological importance PHs have inspired a whole generation of medicinal chemists to come up with novel scaffolds containing phosphorous atom. This review is focused mainly on the compilation of different classes of bioactive phosphorus containing heterocyclic skeletons (which includes phosphorus atom within the heterocyclic ring system or as substituted phosphorus atom attached with another heterocyclic ring system) having both therapeutic and other material chemistry applications since the year 2000 onwards barring their synthetic routes.

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Phosphorus Heterocycles and Their Biological Applications

Kumar,

Mukhopadhyay,

Bhagat

2024

ChemistrySelect

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Design, synthesis, docking, and antiviral evaluation of some novel pyrimidinone-based α-aminophosphonates as potent H1N1 and HCoV-229E inhibitors

Hekal,

Hammad,

El-Brollosy

et al. 2024

Bioorganic Chemistry

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Discovery of new molecular hybrid derivatives with coumarin scaffold bearing pyrazole/oxadiazole moieties: Molecular docking, POM analyses, in silico pharmacokinetics and in vitro antimicrobial evaluation with identification of potent antitumor pharmacophore sites

Tataringa,

Tuchilus,

Ahmed

et al. 2024

Bioorganic Chemistry

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Efficient synthesis, crystallography study, antibacterial/antifungal activities, DFT/ADMET studies and molecular docking of novel α-aminophosphonates

Cited by 11 publications

References 40 publications

Phosphorus Heterocycles and Their Biological Applications

Phosphorus Heterocycles and Their Biological Applications

Design, synthesis, docking, and antiviral evaluation of some novel pyrimidinone-based α-aminophosphonates as potent H1N1 and HCoV-229E inhibitors

Discovery of new molecular hybrid derivatives with coumarin scaffold bearing pyrazole/oxadiazole moieties: Molecular docking, POM analyses, in silico pharmacokinetics and in vitro antimicrobial evaluation with identification of potent antitumor pharmacophore sites

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