Efficient synthesis of 2‐substituted thieno[2,3‐d]pyrimidin‐4(3H)‐ones via an iminophosphorane

Abstract

ABSTRACT:The carbodiimides 4, obtained from reactions of iminophosphorane 3 with aromatic isocyanates, were reacted with secondary amines to

One-Pot Three-Component Synthesis of 1,4-bis[thiazolo[4,5-d]pyrimidin-7(6H)-one]piperazine derivatives

“…In the development of strategies for the preparation of heterocycles, the aza-Wittig reaction has proved to be a powerful tool for the synthesis of 5-8 membered nitrogen heterocycles. [4][5][6] The iminophosphoranes of heterocyclic and heteroaromatic β-enamino esters have proved to be versatile intermediates for the construction of many hetero-condensed systems. Many important nitrogen heterocycles have been synthesized via the aza-Wittig reaction of β-ethoxycarbonyl iminophosphorane with an aromatic isocyanate and a subsequent heterocyclisation reaction with various nucleophiles under mild conditions.…”