Efficient Synthesis of Hydrobenzoin through NHC Catalysis: A Sustainable Approach for C−C Bond Formation

Abstract

A facile and practical one‐pot synthesis of hydrobenzoin has been developed from the readily available aromatic aldehydes, under NHC catalysis. Basically, the present research elucidates a novel, sustainable approach for the synthesis of hydrobenzoin, capitalizing on the catalytic prowess of N‐heterocyclic carbene (NHC) and utilizing sodium borohydride (NaBH4) as an effective reducing partner in this one‐pot conversion. By harnessing the unique reactivity of NHCs, this methodology enables the efficient formation of C−C bonds, leading to the streamlined synthesis of hydrobenzoin with high yields while tolerating various functional groups. Furthermore, this catalytic system offers notable advantages in terms of atom economy, mild reaction conditions, and operational simplicity, making it a promising strategy for sustainable chemical synthesis. The detailed mechanistic insights provided herein shed light on the underlying catalytic pathways, facilitating a deeper understanding of the reaction mechanism. Overall, this study underscores the significant potential of NHC catalysis as a versatile tool for the sustainable synthesis of valuable organic compounds, thereby contributing to the advancement of green chemistry principles and the pursuit of environmentally benign chemical processes.