Efficient synthesis of vitamin E intermediate by lipase-catalyzed regioselective transesterification

Wei, Chun; Fu, Xian-Feng; Wang, Zhao; Yu, Xinjun; Zhang, Yinjun; Zheng, Jingwu

doi:10.1016/j.molcatb.2014.05.003

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Esterification Approach2

Classification Of Enzymes1

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Cited by 9 publications

(3 citation statements)

References 22 publications

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“…Based on initial rate data and concentration profiles, a Ping-Pong bi-bi mechanism with n -butanol inhibition was proposed. 135…”

Section: Classification Of Enzymesmentioning

confidence: 99%

Role of fungal enzymes in the synthesis of pharmaceutically important scaffolds: a green approach

Kumar,

Narula,

Deswal

2023

Green Chem.

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“…Based on initial rate data and concentration profiles, a Ping-Pong bi-bi mechanism with n -butanol inhibition was proposed. 135…”

Section: Classification Of Enzymesmentioning

confidence: 99%

Role of fungal enzymes in the synthesis of pharmaceutically important scaffolds: a green approach

Kumar,

Narula,

Deswal

2023

Green Chem.

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“…In such conditions, the enzyme was active even after 20 cycles. A Ping-Pong bi-bi mechanism with n -butanol inhibition was proposed based on the initial rate data and concentration profiles [ 54 ].…”

Section: Esterification Approachmentioning

confidence: 99%

“… Lipase-catalyzed regioselective transesterification between TMHQ-DA and n -butanol on the preparation of TMHQ-1-MA, an intermediate in the synthesis of Vitamin E acetate [ 54 ]. …”

Section: Esterification Approachmentioning

confidence: 99%

Recent Advances in Lipase-Mediated Preparation of Pharmaceuticals and Their Intermediates

Carvalho

Fonseca

Mattos

et al. 2015

IJMS

124

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Biocatalysis offers an alternative approach to conventional chemical processes for the production of single-isomer chiral drugs. Lipases are one of the most used enzymes in the synthesis of enantiomerically pure intermediates. The use of this type of enzyme is mainly due to the characteristics of their regio-, chemo- and enantioselectivity in the resolution process of racemates, without the use of cofactors. Moreover, this class of enzymes has generally excellent stability in the presence of organic solvents, facilitating the solubility of the organic substrate to be modified. Further improvements and new applications have been achieved in the syntheses of biologically active compounds catalyzed by lipases. This review critically reports and discusses examples from recent literature (2007 to mid-2015), concerning the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs) and their intermediates in which the key step involves the action of a lipase.

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Can vitamin E ester derivatives be excellent alternatives of vitamin E: state of art

Chong

Yuan

et al. 2023

Bioprocess Biosyst Eng

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Efficient synthesis of vitamin E intermediate by lipase-catalyzed regioselective transesterification

Cited by 9 publications

References 22 publications

Role of fungal enzymes in the synthesis of pharmaceutically important scaffolds: a green approach

Role of fungal enzymes in the synthesis of pharmaceutically important scaffolds: a green approach

Recent Advances in Lipase-Mediated Preparation of Pharmaceuticals and Their Intermediates

Can vitamin E ester derivatives be excellent alternatives of vitamin E: state of art

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