Efficient Whole‐Cell Biotransformation in a Biphasic Ionic Liquid/Water System

Pfruender, Holger; Amidjojo, Maya; Kragl, Udo; Weuster‐Botz, Dirk

doi:10.1002/anie.200460241

Cited by 173 publications

(111 citation statements)

References 31 publications

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“…Biocompatible ILs can act as a substrate reservoir and an in situ extracting agent in biotransformations with whole cells (34). In the reduction of 4-chloroacetophenone to (R)-1-(4-chlorophenyl)ethanol, high product concentration (82 g/L −1 ) and purity (99.6% ee) were achieved without the addition of cofactors and without damaging the biocatalyst.…”

Section: Extractionmentioning

confidence: 99%

Ionic Liquids in Chemical Analysis

Koel

2005

Critical Reviews in Analytical Chemistry

330

195

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Room-temperature ionic liquids are salts with a melting point close to or below room temperature. They form liquids composed in the majority of ions. This gives these materials the potential to behave very differently when they are used as solvents compared to conventional molecular liquids. The search for their application is growing in every area of analytical chemistryelectrochemistry, chromatography, electrophoresis, and even mass spectrometry. The literature on ionic liquids is growing almost exponentially. The basis for this activity is the easy preparation of salts with different ion constituents. This ability might best be described as the "chemical tunability" of ionic liquids, a class of solvents with members possessing similar physical properties but having different chemical behavior. Their good solvating properties, together with large spectral transparency, make ionic liquids suitable solvents for spectroscopic measurements. It has been demonstrated that task-specific ionic liquids have advantages compared to common solvents used as separation media in liquid-liquid extraction processes achieving high efficiencies and selectivities of separation. The main advantage for other applications of ionic liquids in analytical chemistry lies in their low volatility which makes them useful as solvents for working in both high-temperature (gas chromatography (GC) stationary phases) and high-vacuum (MALDI matrixes) environments. When using an ionic liquid as an electrolyte medium, it is possible to achieve a broader range of operational temperatures and conditions relative to other conventional electrolytic media, and this makes ionic liquids promising materials in various electrochemical devices (e.g., batteries, fuel cells, sensors, and electrochromic windows).

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Section: Extractionmentioning

confidence: 99%

Ionic Liquids in Chemical Analysis

Koel

2005

Critical Reviews in Analytical Chemistry

330

195

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“…It was shown that the reaction of 2-octanone reduction to 2-octanol catalysed by alcohol dehydrogenase is faster when IL BMIM (CF 3 SO 2 ) 2 N is present in comparison to organic solvent applied so far (Eckstein et al, 2004). Additional beneficial effects of ILs is reduction of the toxicity towards the cell and possibility of their application in whole-cell biocatalysis (Weuster-Botz, 2007;Pfruender et al,. 2004).…”

Section: Liquid-liquid Extraction By Hydrophobic Ionic Liquidsmentioning

confidence: 99%

Ionic Liquids in Separation Techniques

Flieger¹,

Czajkowska-Żelazko²

2011

Applications of Ionic Liquids in Science and Technology

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“…As they do not satisfy the requirements for the matrix used in MALDI-MS, a large number of ILs that exhibit excellent properties in many applications were excluded from use as the matrix in MALDI-MS. For example, MALDI-MS might be a powerful tool for monitoring the reactions or analyzing the reaction products of many biocatalytic reactions that take place in ILs [120,121], but the ILs employed in these reactions do not qualify as MALDI-MS matrices. Using laser desorption/ionization (LDI) and MALDI-MS, Masoud et al [122] 4 ], and studied their application to the analysis of amino acids, peptides and proteins dissolved in these solvents in the presence of other matrix substances such as SA, DHB and CCA.…”

Section: For Maldi-ms Analysismentioning

confidence: 99%

Ionic liquids in sample preparation

et al. 2008

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Due to their unique properties, their good extractabilities for various target analytes, and the fact that many compounds are highly soluble in them, room-temperature ionic liquids (ILs) are used as promising alternatives to the traditional organic solvents employed in sample preparation. ILs have been used as extraction solvents for a wide range of analytes, from environmental contaminates to biomacromolecules and nanomaterials, and as dissolution solvents for various detection techniques. In this paper, the main applications of ILs in sample preparation are reviewed, and the problems and challenges in this area are described.

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Efficient Whole‐Cell Biotransformation in a Biphasic Ionic Liquid/Water System

Cited by 173 publications

References 31 publications

Ionic Liquids in Chemical Analysis

Ionic Liquids in Chemical Analysis

Ionic Liquids in Separation Techniques

Ionic liquids in sample preparation

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