Efficient wound healing by antibacterial property: Advances and trends of hydrogels, hydrogel-metal NP composites and photothermal therapy platforms

Ahmadian, Zainab; Gheybi, Homa; Adeli, Mohsen

doi:10.1016/j.jddst.2022.103458

Cited by 36 publications

(16 citation statements)

References 182 publications

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“…They help regulate plant growth by protecting them from infectious agents ( 199 – 203 ). Tannins can coagulate bacterial cell walls by affecting their peptides ( 196 , 204 , 205 ). Peptide units also make the oocyst wall of Eimeria ( 206 , 207 ); thus, they perforate the oocyst wall of Eimeria oocysts and denature them ( 188 ).…”

Section: Methodsmentioning

confidence: 99%

Botanicals: A promising approach for controlling cecal coccidiosis in poultry

Saeed

Alkheraije

2023

Front. Vet. Sci.

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Avian species have long struggled with the problem of coccidiosis, a disease that affects various parts of the intestine, including the anterior gut, midgut, and hindgut. Among different types of coccidiosis, cecal coccidiosis is particularly dangerous to avian species. Chickens and turkeys are commercial flocks; thus, their parasites have remained critical due to their economic importance. High rates of mortality and morbidity are observed in both chickens and turkeys due to cecal coccidiosis. Coccidiostats and coccidiocidal chemicals have traditionally been added to feed and water to control coccidiosis. However, after the EU banned their use because of issues of resistance and public health, alternative methods are being explored. Vaccines are also being used, but their efficacy and cost-effectiveness remain as challenges. Researchers are attempting to find alternatives, and among the alternatives, botanicals are a promising choice. Botanicals contain multiple active compounds such as phenolics, saponins, terpenes, sulfur compounds, etc., which can kill sporozoites and oocysts and stop the replication of Eimeria. These botanicals are primarily used as anticoccidials due to their antioxidant and immunomodulatory activities. Because of the medicinal properties of botanicals, some commercial products have also been developed. However, further research is needed to confirm their pharmacological effects, mechanisms of action, and methods of concentrated preparation. In this review, an attempt has been made to summarize the plants that have the potential to act as anticoccidials and to explain the mode of action of different compounds found within them.

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Section: Methodsmentioning

confidence: 99%

Botanicals: A promising approach for controlling cecal coccidiosis in poultry

Saeed

Alkheraije

2023

Front. Vet. Sci.

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“…7 Antibiotics, bactericidal metal ions, and inorganic nanomaterials have been incorporated into hydrogels through various methods to eradicate bacteria around wound sites. 8 However, antibiotic-induced resistance, difficulties in nanomaterial degradation, and cytotoxicity limitations have restricted their further potential in biomedical applications. 9 As a natural antimicrobial peptide, ε-polylysine (EPL) has received increasing attention due to its favorable biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

Multifunctional Hydrogel Enhances Inflammatory Control, Antimicrobial Activity, and Oxygenation to Promote Healing in Infectious Wounds

Tang,

Zhao,

et al. 2024

Biomacromolecules

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Chronic infected wounds often fail to heal through normal repair mechanisms, and the persistent response of reactive oxygen species (ROS) and inflammation is a major contributing factor to the difficulty in their healing. In this context, we developed an ROS-responsive injectable hydrogel. This hydrogel is composed of ε-polylysine grafted (EPL) with caffeic acid (CA) and hyaluronic acid (HA) grafted with phenylboronic acid (PBA). Before the gelation process, a mixture CaO 2 @Cur-PDA (CCP) consisting of calcium peroxide (CaO 2 ) coated with polydopamine (PDA) and curcumin (Cur) is embedded into the hydrogel. Under the conditions of chronic refractory wound environments, the hydrogel gradually dissociates. HA mimics the function of the extracellular matrix, while the released caffeic acid-grafted ε-polylysine (CE) effectively eliminates bacteria in the wound vicinity. Additionally, released CA also clears ROS and influences macrophage polarization. Subsequently, CCP further decomposes, releasing Cur, which promotes angiogenesis. This multifunctional hydrogel accelerates the repair of diabetic skin wounds infected with Staphylococcus aureus in vivo and holds promise as a candidate dressing for the healing of chronic refractory wounds.

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“…), while the summary of hydrogels in the field of bionics is lacking. 21,[31][32][33][34][35][36][37][38][39][40] Skinlike material is a hot material in the field of bionics in recent years, which has a very important value in various fields such as wearable sensing devices and human-computer interaction, and is a very hot prospect in the field of hydrogel. Therefore, we systematically summarized the design, properties and applications of skin-like hydrogels in the field of sensing, which can provide more comprehensive experience for the development of hydrogels in the field of bionics compared with the current review.…”

Section: Introductionmentioning

confidence: 99%