Effluent concentration profiles in centrifugal partition chromatography

Abstract

Centrifugal partition chromatography (CPC) is a relatively new preparative chro-

Mass transport and flow regimes in centrifugal partition chromatography

“…Those re-Ž . sults are in the same range as that in van Buel et al 1997 using Sanki instruments. This could be explained by the fact that the flow regimes observed by van Buel et al correspond Ž .…”

“…et al 1992 for percolation processes, and applied to CPC by Ž . van Buel et al 1997 . Owing to the model parameters, it is now possible to locate the origin of band broadening in the column.…”

Methodology for optimally sized centrifugal partition chromatography columns

“…For the mass transfer kinetics, evaluation was based on the modeling of chromatographic processes introduced by Van Deemter [25], Villermaux [26], Van Buel et al [27] and Marchal et al [13]. The model is a plug flow with axial dispersion and mass transfer with the stationary phase.…”

Centrifugal partition chromatography: A survey of its history, and our recent advances in the field

“…That is why L. van der Wielen and K. Luyben underwent the realization of a transparent CPC cartridge and a rotor, the channel and duct dimensions and geometries being equal to those of the commercial CPC‐LLN. They interested Michel van Buel, who was beginning a Ph.D. on the project, and this group of scientists then built a milestone in the story of CPC, as evidenced by their publications 28–33. They presented photographs of the flow‐states inside of a CPC column, and through a chemical engineering approach they were able to model the effluent concentration profiles31 and gradient elution profiles,30 and to adapt the model to the case of large injections of weak acids (hop acids) 34, 35…”