Efflux systems as a target for anti-biofilm nanoparticles: perspectives on emerging applications

Musiol, Robert

doi:10.1080/14728222.2023.2263910

Expert Opinion on Therapeutic Targets

2023

DOI: 10.1080/14728222.2023.2263910

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Efflux systems as a target for anti-biofilm nanoparticles: perspectives on emerging applications

Robert Musiol

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2024

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Cited by 6 publications

References 99 publications

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Anti-microbial, anti-biofilm, and efflux pump inhibitory effects of ellagic acid–bonded magnetic nanoparticles against Escherichia coli isolates

Norouzalinia,

Asadpour,

Mokhtary

2024

Int Microbiol

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Anti-microbial, anti-biofilm, and efflux pump inhibitory effects of ellagic acid–bonded magnetic nanoparticles against Escherichia coli isolates

Norouzalinia,

Asadpour,

Mokhtary

2024

Int Microbiol

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Boosting Gentamicin Activity Against Pseudomonas aeruginosa Using Nano-formulation of Curcumin

Mohanty,

Yadav

2024

BioNanoSci.

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Nanoparticles in the battle against Candida auris biofilms: current advances and future prospects

Fayed

2024

Drug Deliv. and Transl. Res.

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Candida auris has emerged as a significant global health threat due to its multidrug resistance and ability to form robust biofilms, particularly on medical devices and hospital surfaces. Biofilms protect C. auris from antifungal treatments and the host immune response, making infections persistent and difficult to control. This review explores the potential of nanoparticles to overcome the limitations of traditional antifungal therapies in combating C. auris biofilms. Nanoparticles, with their unique physicochemical properties, offer promising strategies to penetrate biofilm matrices, deliver antifungal agents, and disrupt biofilm structure. Various types of nanoparticles, including metallic, polymeric, lipid-based, and cyclodextrin-based, demonstrate enhanced biofilm penetration and antifungal activity. Their ability to generate reactive oxygen species, disrupt cell adhesion, and release antifungals in a controlled manner makes them ideal candidates for biofilm-targeted therapies. This review presents the current advancements in nanoparticle-based solutions, emphasizing the need for further research into their mechanisms of action, safety, and clinical application. By addressing the challenge of C. auris biofilms specifically, this review provides a critical synthesis of existing knowledge and identifies future directions for developing effective antifungal therapies using nanotechnology. Graphical abstract

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Efflux systems as a target for anti-biofilm nanoparticles: perspectives on emerging applications

Cited by 6 publications

References 99 publications

Anti-microbial, anti-biofilm, and efflux pump inhibitory effects of ellagic acid–bonded magnetic nanoparticles against Escherichia coli isolates

Anti-microbial, anti-biofilm, and efflux pump inhibitory effects of ellagic acid–bonded magnetic nanoparticles against Escherichia coli isolates

Boosting Gentamicin Activity Against Pseudomonas aeruginosa Using Nano-formulation of Curcumin

Nanoparticles in the battle against Candida auris biofilms: current advances and future prospects

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