Eficacia de la terapia de ondas de choque de baja intensidad para la disfunción eréctil: revisión sistemática y metaanálisis

Angulo, Javier C.; Arance, I.; Heras, Mar; Meilán, E.; Esquinas, Cristina; Andrés, Erik

doi:10.1016/j.acuro.2016.07.005

Cited by 25 publications

(4 citation statements)

References 36 publications

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“…Thus, the overall long-term clinical effects of Li-ESWT, whether focused or linear SW delivery, seem to be doubtful. Indeed, there is reason to doubt the short-term clinical effects of Li-ESWT, because results from randomized trials have been inconsistent, and only 1 of 3 systematic reviews and meta-analyses on Li-ESWT for ED has documented increases in IIEF-EF 4 , 5 , 19 to what is considered the minimal clinically important difference (ΔIIEF-EF score > 4). 20 Whether repeated treatment sessions over a longer period might stimulate cellular and molecular mechanisms, which are believed to be involved in angiogenesis and nerve regeneration translating into significant clinical effects, still needs to be evaluated in controlled trials.…”

Section: Discussionmentioning

confidence: 99%

Effect of Linear Low-Intensity Extracorporeal Shockwave Therapy for Erectile Dysfunction—12-Month Follow-Up of a Randomized, Double-Blinded, Sham-Controlled Study

2017

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IntroductionShort-term data on the effect of low-intensity extracorporeal shockwave therapy (Li-ESWT) on erectile dysfunction (ED) have been inconsistent. The suggested mechanisms of action of Li-ESWT on ED include stimulation of cell proliferation, tissue regeneration, and angiogenesis, which can be processes with a long generation time. Therefore, long-term data on the effect of Li-ESWT on ED are strongly warranted.AimTo assess the outcome at 6 and 12 months of linear Li-ESWT on ED from a previously published randomized, double-blinded, sham-controlled trial.MethodsSubjects with ED (N = 126) who scored lower than 25 points in the erectile function domain of the International Index of Erectile Function (IIEF-EF) were eligible for the study. They were allocated to 1 of 2 groups: 5 weekly sessions of sham treatment (group A) or linear Li-ESWT (group B). After a 4-week break, the 2 groups received active treatment once a week for 5 weeks. At baseline and 6 and 12 months, subjects were evaluated by the IIEF-EF, the Erectile Hardness Scale (EHS), and the Sexual Quality of Life in Men.Main Outcome MeasuresThe primary outcome measure was an increase of at least 5 points in the IIEF-EF (ΔIIEF-EF score). The secondary outcome measure was an increase in the EHS score to at least 3 in men with a score no higher than 2 at baseline. Data were analyzed by linear and logistic regressions.ResultsLinear regression of the ΔIIEF-EF score from baseline to 12 months included 95 patients (dropout rate = 25%). Adjusted for the IIEF-EF score at baseline, the difference between groups B and A was −1.30 (95% CI = −4.37 to 1.77, P = .4). The success rate based on the main outcome parameter (ΔIIEF-EF score ≥ 5) was 54% in group A vs 47% in group B (odds ratio = 0.67, P = .28). Improvement based on changes in the EHS score in groups A and B was 34% and 24%, respectively (odds ratio = 0.47, P = .82).ConclusionExposure to 2 cycles of linear Li-ESWT for ED is not superior to 1 cycle at 6- and 12-month follow-ups.Fojecki GL, Tiessen S, Osther PJS. Effect of Linear Low-Intensity Extracorporeal Shockwave Therapy for Erectile Dysfunction—12-Month Follow-Up of a Randomized, Double-Blinded, Sham-Controlled Study. Sex Med 2018;6:1–7.

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Section: Discussionmentioning

confidence: 99%

Effect of Linear Low-Intensity Extracorporeal Shockwave Therapy for Erectile Dysfunction—12-Month Follow-Up of a Randomized, Double-Blinded, Sham-Controlled Study

2017

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“…Nevertheless, the data on long-term efficiency is insufficient to conclude. However, more studies are needed to be done on the application of low-intensity shockwave therapy according to the different causes of ED [ 33 ]. In another study, sublingual apomorphine was studied for its effectiveness in patients who are unable to take PDE-5 inhibitors.…”

Section: Prospection Of Scholarly Articlesmentioning

confidence: 99%

The Race to Replace PDE5i: Recent Advances and Interventions to Treat or Manage Erectile Dysfunction: Evidence from Patent Landscape (2016–2021)

Islam

Naveen²,

Anitha³

et al. 2022

JCM

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For a few decades, globally, erectile dysfunction (ED) has become more prominent even in young adults and represents a mounting health concern causing a significant effect on men’s quality of life. There is an expectation that by the end of 2025, the number of ED cases can rise to 322 million. We aimed to comprehensively analyze the scientific output of scholarly articles and studies in the field of ED (2016–2021). Data from scholarly articles were collected using Pubmed, and clinical trials-related information was accessed from the clinical trials website. An extensive patent search was conducted using databases such as USPTO (United States patent and trademark office) and EPO (European patent office), WIPO (World Intellectual Property Organization), etc. Owing to the high market value of ED drugs, considerable interest was attained to grab the opportunities. The race to replace the phosphodiesterase type 5 inhibitor (PDE5 inhibitor-PDE5i) can be identified as evident from the significant number of patents filed and the inventions cleared with clinical trials. Some other intriguing interventions are identified for ED treatment but have yet to gain public acceptance. The current analysis confirms the overall evolution and unexplored corners of research on ED treatment strategies with a current global projection.

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“…More clinical studies have been conducted since then revealing encouraging results, such as the improvement of International Index of Erectile Function score and/or Erectile Hardness Score and an effect that lasts up to 1 year (5-10). Therefore, it seems that Li-ESWT has the potential to become the first non-invasive curative treatment for ED patients (11-13). …”

mentioning

confidence: 99%

Low-energy shock wave therapy ameliorates erectile dysfunction in a pelvic neurovascular injuries rat model

Behr‐Roussel¹,

Giuliano²

2016

Transl. Androl. Urol.

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Eficacia de la terapia de ondas de choque de baja intensidad para la disfunción eréctil: revisión sistemática y metaanálisis

Cited by 25 publications

References 36 publications

Effect of Linear Low-Intensity Extracorporeal Shockwave Therapy for Erectile Dysfunction—12-Month Follow-Up of a Randomized, Double-Blinded, Sham-Controlled Study

Effect of Linear Low-Intensity Extracorporeal Shockwave Therapy for Erectile Dysfunction—12-Month Follow-Up of a Randomized, Double-Blinded, Sham-Controlled Study

The Race to Replace PDE5i: Recent Advances and Interventions to Treat or Manage Erectile Dysfunction: Evidence from Patent Landscape (2016–2021)

Low-energy shock wave therapy ameliorates erectile dysfunction in a pelvic neurovascular injuries rat model

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