EGA–MS study to characterize the thermally induced decomposition of Co(II), Ni(II), Cu(II) and Zn(II) complexes with 1,1-diaminobutane-Schiff base

Materazzi, Stefano; Risoluti, Roberta; Napoli, Anna

doi:10.1016/j.tca.2015.03.009

Cited by 42 publications

(9 citation statements)

References 30 publications

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“…Thermogravimetric techniques have been largely applied to complex matrix as analytical tool that does not require sample pretreatment nor clean-up (Toth et al, 2010;Fonseca et al, 2012;Materazzi et al, 2015Materazzi et al, , 2017aPapadopoulos et al, 2016;Risoluti et al, 2016bRisoluti et al, , 2017Bach and Chen, 2017;Catauro et al, 2018) and permits to rapidly obtain both qualitative and quantitative outcomes (Skreiberg et al, 2011;Materazzi et al, 2014a,b;Napoli et al, 2014;Shan-Yang et al, 2015;Marcilla et al, 2017). Recently, a novel approach based on the association of thermogravimetric analysis (TGA) and chemometrics has been proposed in different fields (Pappa et al, 2003;Khanmohammadi et al, 2012;Caramés-Alfaya et al, 2013;Chauhan et al, 2020), including the investigation of biological samples for clinical analysis (Risoluti et al, 2016a(Risoluti et al, , 2018aMaterazzi et al, 2017a).…”

Section: Introductionmentioning

confidence: 99%

An Innovative Multilevel Test for Hemoglobinopathies: TGA/Chemometrics Simultaneously Identifies and Classifies Sickle Cell Disease From Thalassemia

Risoluti

Caprari

Gullifa

et al. 2020

Front. Mol. Biosci.

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Introduction: Hemoglobinopathies are the most common genetic disorder wordlwide and because of migrations are become an emerging global health problem. Screening programmes for Sickle cell disease and Thalassemia have been implemented in some countries, but are not a common practice, due to a lack in the accuracy of the methods and to the costs of the analyses. Objectives: The objective of this study was the application of the thermogravimetry coupled to chemometrics as new screening method to perform an early diagnosis of thalassemia and sickle cell disease. Methods: Whole blood samples (30 µL) from sickle cell anemia and thalassemia patients were analyzed using the thermobalance TG7 and the resulting curves were compared with those of healthy individuals. A chemometric approach based on Principal Components Analysis (PCA) was exploited to enhance correlation between thermogravimetric profiles and a model of prediction by Partial Least Square Discriminant Analysis (PLS-DA) was developed and validated. Results: The characteristic profile of the blood sample thermal decomposition and the first derivative of the TG curve showed that patients were clearly distinguished from healthy individuals as a result of different amounts of water and corpuscular fraction of blood. The chemometric approach based on PCA allowed a quick identification of differences between healthy subjects and patients and also between thalassemic and sickle cell anemia subjects. Chemometric tools (PLS-DA) were used to validate a model of prediction to process the thermogravimetric curves and to obtain in 1 h an accurate diagnosis. The TGA/Chemometric test permitted to perform first level test for hemoglobinopathies with the same accuracy of confirmatory analyses obtained by the molecular investigation. Conclusions: A screening test based on the coupling of thermogravimetry and chemometrics was optimized for the differential diagnosis of hemoglobinopathies. The novel test is able to simultaneously perform a simple and fast diagnosis of sickle cell Risoluti et al. Innovative Multilevel Test for Hemoglobinopathies anemia or thalassemia, in a single analysis of few microliters of non-pretreated whole blood at low cost, and with high accuracy. Moreover this method results particularly suitable in pediatric patients as it requires small sample volumes and is able to characterize also transfused patients.

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Section: Introductionmentioning

confidence: 99%

An Innovative Multilevel Test for Hemoglobinopathies: TGA/Chemometrics Simultaneously Identifies and Classifies Sickle Cell Disease From Thalassemia

Risoluti

Caprari

Gullifa

et al. 2020

Front. Mol. Biosci.

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“…However, this treatment was not well-tolerated by thalassemic and SCD patients and the use has been severely reduced because ribavirin (RBV) proved to cause hemolytic anemia and to increase blood transfusions, in addition to interferon side effects, such as influenza-like symptoms, depression and cytopenias (Materazzi et al, 2014a;Origa et al, 2015;Di Marco et al, 2016;Moon et al, 2017). More recently, the use of Direct-acting Antiviral Agents (DAAs) demonstrated to be suitable in HCV management in patients with thalassemia and sickle cell disease for whom previous regimens gave restrictions (Materazzi et al, 2015(Materazzi et al, , 2017aDi Marco et al, 2016;Moon et al, 2017;Origa et al, 2017;Premkumar et al, 2017;Mehta et al, 2018).…”

Section: Hcv Therapy: Interferonmentioning

confidence: 99%

HCV Infection in Thalassemia Syndromes and Hemoglobinopathies: New Perspectives

Maffei

Sorrentino

Caprari

et al. 2020

Front. Mol. Biosci.

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“…This hyphenated approach is recognized as a very useful tool to propose decomposition mechanisms for precipitated complexes [44,45,46,47,48]. To step ahead, our group recently suggested new trends in thermal analysis [49,50,51,52,53,54,55] also comparing a new approach by portable microNIR, both oriented on the application of chemometrics [56,57].…”

Section: Introductionmentioning

confidence: 99%

“…This behavior was recorded with ligands, such as (1-methylimidazol-2-yl)ketone, dopamine, and derived structures. All these studies are described in the references [57,58,59,60,61,62,63,64,65,66,67,68] and are the experimental evidences on which the proposed model is based. This thermally induced behavior, and the consequently derived model, is proposed as a tool to provide stability information on the complexes to be related to speciation studies.…”

Section: Introductionmentioning

confidence: 99%

Modeling Solid State Stability for Speciation: A Ten-Year Long Study

et al. 2019

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Speciation studies are based on fundamental models that relate the properties of biomimetic coordination compounds to the stability of the complexes. In addition to the classic approach based on solution studies, solid state properties have been recently proposed as supporting tools to understand the bioavailability of the involved metal. A ten-year long systematic study of several different complexes of imidazole substituted ligands with transition metal ions led our group to the definition of a model based on experimental evidences. This model revealed to be a useful tool to predict the stability of such coordination complexes and is based on the induced behavior under thermal stress. Several different solid state complexes were characterized by Thermally Induced Evolved Gas Analysis by Mass Spectrometry (TI-EGA-MS). This hyphenated technique provides fundamental information to determine the solid state properties and to create a model that relates stability to coordination. In this research, the model resulting from our ten-year long systematic study of complexes of transition metal ions with imidazole substituted ligands is described. In view of a systematic addition of information, new complexes of Cu(II), Zn(II), or Cd(II) with 2-propyl-4,5-imidazoledicarboxylic acid were precipitated, characterized, and studied by means of Thermally Induced Evolved Gas Analysis performed by mass spectrometry (TI-EGA-MS). The hyphenated approach was applied to enrich the information related to thermally induced steps, to confirm the supposed decomposition mechanism, and to determine the thermal stability of the studied complexes. Results, again, allowed supporting the theory that only two main characteristic and common thermally induced decomposition behaviors join the imidazole substituted complexes studied by our group. These two behaviors could be considered as typical trends and the model allowed to predict coordination behavior and to provide speciation information.

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EGA–MS study to characterize the thermally induced decomposition of Co(II), Ni(II), Cu(II) and Zn(II) complexes with 1,1-diaminobutane-Schiff base

Cited by 42 publications

References 30 publications

An Innovative Multilevel Test for Hemoglobinopathies: TGA/Chemometrics Simultaneously Identifies and Classifies Sickle Cell Disease From Thalassemia

An Innovative Multilevel Test for Hemoglobinopathies: TGA/Chemometrics Simultaneously Identifies and Classifies Sickle Cell Disease From Thalassemia

HCV Infection in Thalassemia Syndromes and Hemoglobinopathies: New Perspectives

Modeling Solid State Stability for Speciation: A Ten-Year Long Study

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